Drug & supplement interaction

Cudweed + rosiglitazone, glimepiride

rosiglitazone, glimepiride brand name: Avandaryl.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Cudweed has a moderate interaction with rosiglitazone, glimepiride. Preliminary research in rats shows that cudweed might lower blood glucose levels.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Cudweed and rosiglitazone, glimepiride

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to rosiglitazone, glimepiride

rosiglitazone, glimepiride falls under ANTIDIABETES DRUGS — the group Cudweed interacts with.

Preliminary research in rats shows that cudweed might lower blood glucose levels. Theoretically, taking cudweed with drugs that lower blood glucose levels might increase the risk of hypoglycemia. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Avandaryl is a combo of two diabetes medicines: rosiglitazone and glimepiride. Glimepiride in particular works by squeezing more insulin out of your pancreas, so it can push your blood sugar down on its own. The concern here is simple addition. Early research in rats hints that cudweed may also nudge blood sugar lower, so stacking it on top of these medicines could, in theory, drop your levels a little too far.

If that happened, you might notice shakiness, sweating, dizziness, hunger, or confusion, the usual signs of low blood sugar. Honestly though, this is weak, animal-only evidence, so I wouldn't lose sleep over it. Just let your doctor or pharmacist know before adding cudweed, and keep an eye on your numbers if you do.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Shikov AN, Pozharitskaya ON, Makarov VG, et al. Medicinal plants of the Russian Pharmacopoeia; their history and applications. J Ethnopharmacol 2014;154(3):481-536. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Cudweed Also Interacts With Other Medications

Cudweed has 85 moderate known drug interactions in our database — the rosiglitazone, glimepiride one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. rosiglitazone, glimepiride)
Taking anything else?

Check Another of Your Medications Against Cudweed

Covers the 2,830 medications we’ve checked against Cudweed. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With rosiglitazone, glimepiride

This page covers Cudweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the rosiglitazone, glimepiride page lists 308 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 258 moderate · 48 minor.

From our pharmacist’s overview on the rosiglitazone, glimepiride page

“Siberian cocklebur worries me most on this page. Its seeds have caused severe, worsening drops in blood sugar in people, and rosiglitazone with glimepiride (Avandaryl) already pulls glucose down through two separate mechanisms, so these pairings deserve real vigilance.”

Reviewed by 2 · Jul 18, 2026

Open the rosiglitazone, glimepiride interaction page

How much people look this up

Where Cudweed and rosiglitazone, glimepiride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cudweed
Top half

#683 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication rosiglitazone, glimepiride
Top half

#865 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Cudweed

What is Cudweed?

  • Mouth and throat irritation
  • Digestive upset
  • Mild high blood pressure (traditional)
  • Minor wounds and skin irritation
  • Coughs and respiratory complaints

Cudweed is a small, woolly-leaved plant used in traditional herbal medicine, mainly as a tea or gargle for sore throats, digestive upset, and minor skin problems. There is very little modern scientific evidence to confirm that it works for any condition, and safety data are limited, so it is best used cautiously and avoided in pregnancy and breastfeeding.

Read the full Cudweed monograph & all interactions
Keep checking

Other Drugs & Cudweed

Browse every other medication we’ve checked against Cudweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Cudweed page.

No interaction 2,744 drugs checked — show the list

We also checked Cudweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Cudweed list.

See the full Cudweed interactions page
See every supplement checked against rosiglitazone, glimepiride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Cudweed monograph › Uses, safety, and every drug interaction in one place rosiglitazone, glimepiride supplement interactions › Every supplement checked against rosiglitazone, glimepiride, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Cudweed and rosiglitazone, glimepiride Together: Common Questions

Can you take Cudweed with rosiglitazone, glimepiride?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Cudweed and rosiglitazone, glimepiride interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About rosiglitazone, glimepiride and Cudweed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.