Medication interaction hub

What Supplements Interact with rosiglitazone, glimepiride?

rosiglitazone, glimepiride brand name: Avandaryl. Every interaction below applies to the brands too.

308 Interactions 2 Major 258 Moderate 48 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with rosiglitazone, glimepiride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check rosiglitazone, glimepiride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Siberian cocklebur worries me most on this page. Its seeds have caused severe, worsening drops in blood sugar in people, and rosiglitazone with glimepiride (Avandaryl) already pulls glucose down through two separate mechanisms, so these pairings deserve real vigilance. The same pattern shapes almost the whole page. Of 308 supplements with an interaction on file, 239 can add to the glucose-lowering effect, bitter melon among them, raising the odds of shakiness, confusion, or worse.

Activated charcoal is the other major-rated risk. Taken near a dose, it can soak up the medication before the body absorbs it, so keep the two well apart if you use it. The remaining 258 moderate and 48 minor entries mostly nudge blood sugar one way or the other, slow how the liver clears the drug, or add to sun sensitivity. Checking your glucose more often is the simplest protection when a supplement joins this pill.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 258 Minor 48 No known interaction 1,144

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

rosiglitazone, glimepiride: Top Interactions at a Glance

The most significant rosiglitazone, glimepiride supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 308 interacting ingredients — plus 1,144 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant rosiglitazone, glimepiride + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + rosiglitazone, glimepiridei

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction Major Likelihood Probable Activated Charcoal + rosiglitazone, glimepiridei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against rosiglitazone, glimepiride

All 1,452 ingredients in our database, ranked by severity — 308 with a rosiglitazone, glimepiride interaction on file and 1,144 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With rosiglitazone, glimepiride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bael with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that extracts of bael seed and leaf can reduce blood glucose levels.

Full Bael + rosiglitazone, glimepiride answer

Can you take Papaya with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.

Full Papaya + rosiglitazone, glimepiride answer

Can you take Prickly Pear Cactus with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Prickly Pear Cactus + rosiglitazone, glimepiride answer

Can you take Ribose with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ribose + rosiglitazone, glimepiride answer

Can you take Salacia with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Salacia + rosiglitazone, glimepiride answer

Can you take Sida Cordifolia with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Sida cordifolia might reduce the effectiveness of antidiabetes drugs.

Full Sida Cordifolia + rosiglitazone, glimepiride answer

Can you take Tree Turmeric with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking an...

Full Tree Turmeric + rosiglitazone, glimepiride answer

Can you take Vanadium with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Vanadium + rosiglitazone, glimepiride answer

Can you take Wild Carrot with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Wild Carrot + rosiglitazone, glimepiride answer

Can you take Wine with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may interfere with blood glucose control.

Full Wine + rosiglitazone, glimepiride answer

Can you take Acai with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Full Acai + rosiglitazone, glimepiride answer

Can you take Adrafinil with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might increase the levels and clinical effects of CYP2C9 substrates.

Full Adrafinil + rosiglitazone, glimepiride answer

Can you take African Wild Potato with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract inhibits cytochrome P450 2C9 (CYP2C9).

Full African Wild Potato + rosiglitazone, glimepiride answer

Can you take Agaricus Mushroom with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Agaricus Mushroom + rosiglitazone, glimepiride answer

Can you take Agmatine with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Agmatine + rosiglitazone, glimepiride answer

Can you take Agrimony with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking agrimony with antidiabetes drugs might increase the risk of hypoglycemia.

Full Agrimony + rosiglitazone, glimepiride answer

Can you take Alfalfa with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Full Alfalfa + rosiglitazone, glimepiride answer

Can you take Algal Oil with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.

Full Algal Oil + rosiglitazone, glimepiride answer

Can you take Aloe with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Aloe + rosiglitazone, glimepiride answer

Can you take Ambrette with rosiglitazone, glimepiride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ambrette + rosiglitazone, glimepiride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) rosiglitazone, glimepiride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by rosiglitazone, glimepiride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

rosiglitazone, glimepiride sits in 7 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach rosiglitazone, glimepiride through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach rosiglitazone, glimepiride through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach rosiglitazone, glimepiride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach rosiglitazone, glimepiride through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach rosiglitazone, glimepiride through this category.

Rosiglitazone (Avandia) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches rosiglitazone, glimepiride through this category.

Sulfonylureas 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches rosiglitazone, glimepiride through this category.

Related: does rosiglitazone, glimepiride deplete any nutrients?

rosiglitazone, glimepiride has 1 reported nutrient association in the research literature — see the rosiglitazone, glimepiride nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against rosiglitazone, glimepiride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against rosiglitazone, glimepiride.

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Pharmacist Counseling Corner

rosiglitazone, glimepiride & Supplements: Common Questions

What supplements interact with rosiglitazone, glimepiride?
Our database currently documents 308 ingredients with a known rosiglitazone, glimepiride interaction (2 major, 258 moderate, 48 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 308. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which rosiglitazone, glimepiride supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on rosiglitazone, glimepiride?
Plenty of supplements coexist fine with rosiglitazone, glimepiride; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Avandaryl have the same supplement interactions as rosiglitazone, glimepiride?
Yes — Avandaryl all contain rosiglitazone, glimepiride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does rosiglitazone, glimepiride deplete any vitamins or nutrients?
It might — rosiglitazone, glimepiride has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the rosiglitazone, glimepiride nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about rosiglitazone, glimepiride and my other medications?
This page covers rosiglitazone, glimepiride against supplements and herbal ingredients. Checking rosiglitazone, glimepiride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.