Drug & supplement interaction

Ba Ji Tian + rosiglitazone, glimepiride

rosiglitazone, glimepiride brand name: Avandaryl.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Ba Ji Tian has a moderate interaction with rosiglitazone, glimepiride. Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Ba Ji Tian and rosiglitazone, glimepiride

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to rosiglitazone, glimepiride

rosiglitazone, glimepiride falls under ANTIDIABETES DRUGS — the group Ba Ji Tian interacts with.

Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels. Theoretically ba ji tian might have additive effects or attenuate the effects antidiabetes drugs. Monitor blood glucose levels closely; dose adjustments of antidiabetes drugs might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Avandaryl combines two diabetes medicines: glimepiride, which pushes your body to release more insulin, and rosiglitazone, which helps your cells respond to insulin better. Both work to lower blood sugar. The concern with Ba Ji Tian is unpredictability. In animal studies it has nudged blood sugar in both directions, so when paired with your medication it could either add to the sugar-lowering (raising your risk of a low, with shakiness, sweating, dizziness, or confusion) or work against it (leaving your sugars running high).

Keep in mind this is theoretical, based mostly on lab and animal work, not solid human studies. If you do take it, check your glucose more often than usual and let your doctor or pharmacist know before starting, since your dose may need a tweak.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Soon, Y. Y. and Tan, B. K. Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Med J 2002;43(2):077-085.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Ba Ji Tian Also Interacts With Other Medications

Ba Ji Tian has 85 moderate known drug interactions in our database — the rosiglitazone, glimepiride one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. rosiglitazone, glimepiride)
Taking anything else?

Check Another of Your Medications Against Ba Ji Tian

Covers the 2,830 medications we’ve checked against Ba Ji Tian. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With rosiglitazone, glimepiride

This page covers Ba Ji Tian only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the rosiglitazone, glimepiride page lists 308 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 258 moderate · 48 minor.

From our pharmacist’s overview on the rosiglitazone, glimepiride page

“Siberian cocklebur worries me most on this page. Its seeds have caused severe, worsening drops in blood sugar in people, and rosiglitazone with glimepiride (Avandaryl) already pulls glucose down through two separate mechanisms, so these pairings deserve real vigilance.”

Reviewed by 2 · Jul 18, 2026

Open the rosiglitazone, glimepiride interaction page

One more smart check

Taking Ba Ji Tian as Part of a Dietary Supplement Product? Check It for Interactions

We hold 43 real supplement products containing Ba Ji Tian, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ba Ji Tian. Your product may carry other ingredients that interact with rosiglitazone, glimepiride too, on top of Ba Ji Tian — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ba Ji Tian and rosiglitazone, glimepiride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ba Ji Tian
Top half

#417 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication rosiglitazone, glimepiride
Top 25%

#575 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Ba Ji Tian

What is Ba Ji Tian?

Ba Ji Tian
  • Kidney 'yang' tonic in Traditional Chinese Medicine
  • Low libido and erectile concerns
  • Bone and joint health
  • Fatigue and low vitality
  • Low mood

Ba Ji Tian is a root used in Traditional Chinese Medicine, mostly to 'tonify the kidneys' and support energy, sexual function, and bone health. Modern evidence in humans is very limited, and most claims come from laboratory or animal studies. If you want to try it, talk with a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Read the full Ba Ji Tian monograph & all interactions
Keep checking

Other Drugs & Ba Ji Tian

Browse every other medication we’ve checked against Ba Ji Tian — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Ba Ji Tian page.

No interaction 2,744 drugs checked — show the list

We also checked Ba Ji Tian against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Ba Ji Tian list.

See the full Ba Ji Tian interactions page
See every supplement checked against rosiglitazone, glimepiride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Ba Ji Tian monograph › Uses, safety, and every drug interaction in one place rosiglitazone, glimepiride supplement interactions › Every supplement checked against rosiglitazone, glimepiride, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Ba Ji Tian and rosiglitazone, glimepiride Together: Common Questions

Can you take Ba Ji Tian with rosiglitazone, glimepiride?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Ba Ji Tian and rosiglitazone, glimepiride interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About rosiglitazone, glimepiride and Ba Ji Tian?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.