Medication interaction hub

What Supplements Interact with Rosiglitazone Maleate?

Rosiglitazone Maleate brand name: Avandia. Every interaction below applies to the brands too.

314 Interactions 4 Major 266 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Rosiglitazone Maleate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Rosiglitazone Maleate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Rosiglitazone (Avandia) lowers blood sugar in type 2 diabetes, and most of the 314 supplements and herbs on this page pull on that same lever. Some 239 can move blood glucose on their own, so adding one risks hypoglycemia, the shakiness, sweating, and confusion of sugar falling too low. This list calls for real caution, starting with the four major entries. Siberian cocklebur has caused documented liver injury, and heavy alcohol carries the same liver risk, accounting for two of the four.

Activated charcoal is the fourth major. It soaks up medicines in the gut and can blunt the dose, and bulky fiber supplements do the same in milder form, so keep them well apart from when you take rosiglitazone. With 266 moderate and 44 minor entries besides, the steady habit that protects you is checking your glucose more often whenever a supplement joins your regimen.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 266 Minor 44 No known interaction 1,138

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Rosiglitazone Maleate: Top Interactions at a Glance

The Rosiglitazone Maleate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 314 interacting ingredients — plus 1,138 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Rosiglitazone Maleate Combinations Today

The Rosiglitazone Maleate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Feverfew + Rosiglitazone Maleatei

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.

Read the full interaction Moderate Likelihood Possible Brewer's Yeast + Rosiglitazone Maleatei

Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Kombucha + Rosiglitazone Maleatei

Theoretically, kombucha might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Terminalia Chebula + Rosiglitazone Maleatei

Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Zeaxanthin + Rosiglitazone Maleatei

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Arabinoxylan + Rosiglitazone Maleatei

Evidence from human research suggests that an arabinoxylan-rich fiber can reduce postprandial glucose levels.

Read the full interaction
The complete list

Every Supplement Checked Against Rosiglitazone Maleate

All 1,452 ingredients in our database, ranked by severity — 314 with a Rosiglitazone Maleate interaction on file and 1,138 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Rosiglitazone Maleate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Feverfew with Rosiglitazone Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.

Full Feverfew + Rosiglitazone Maleate answer

Can you take Brewer's Yeast with Rosiglitazone Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.

Full Brewer's Yeast + Rosiglitazone Maleate answer

Can you take Kombucha with Rosiglitazone Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kombucha might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Kombucha + Rosiglitazone Maleate answer

Can you take Terminalia Chebula with Rosiglitazone Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypog...

Full Terminalia Chebula + Rosiglitazone Maleate answer

Can you take Zeaxanthin with Rosiglitazone Maleate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.

Full Zeaxanthin + Rosiglitazone Maleate answer

Can you take Agar with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Rosiglitazone Maleate answer

Can you take Algin with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Rosiglitazone Maleate answer

Can you take Apple Cider Vinegar with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Full Apple Cider Vinegar + Rosiglitazone Maleate answer

Can you take Black Psyllium with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Rosiglitazone Maleate answer

Can you take Blond Psyllium with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Rosiglitazone Maleate answer

Can you take Calea Zacatechichi with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.

Full Calea Zacatechichi + Rosiglitazone Maleate answer

Can you take Carob with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Rosiglitazone Maleate answer

Can you take Evening Primrose with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, evening primrose may increase the levels and clinical effects of CYP2C9 substrates.

Full Evening Primrose + Rosiglitazone Maleate answer

Can you take Fucus Vesiculosus with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of Fucus vesiculosus with CYP2C9 substrates might increase the risk for adverse effects.

Full Fucus Vesiculosus + Rosiglitazone Maleate answer

Can you take Genistein Combined Polysaccharide with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Some evidence suggests that genistein can alter the pharmacokinetics of CYP2C9 substrates and should be used cautiously with them.

Full Genistein Combined Polysaccharide + Rosiglitazone Maleate answer

Can you take Goli Apple Cider Vinegar Gummies with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar, which is contained in Goli ACV, with antidiabetes drugs might increase the risk of hypoglycemia (...

Full Goli Apple Cider Vinegar Gummies + Rosiglitazone Maleate answer

Can you take Karaya Gum with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Rosiglitazone Maleate answer

Can you take Maqui with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, maqui fruit extract may increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Maqui + Rosiglitazone Maleate answer

Can you take Marshmallow with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Rosiglitazone Maleate answer

Can you take Moringa with Rosiglitazone Maleate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, moringa might have additive effects when used with antidiabetes drugs; however, research is conflicting.

Full Moringa + Rosiglitazone Maleate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Rosiglitazone Maleate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Rosiglitazone Maleate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Rosiglitazone Maleate sits in 6 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Rosiglitazone Maleate through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Rosiglitazone Maleate through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Rosiglitazone Maleate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Rosiglitazone Maleate through this category.

Cytochrome P450 2C8 (Cyp2C8) Substrates 11 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

11 of the supplement ingredients on this page reach Rosiglitazone Maleate through this category.

Rosiglitazone (Avandia) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Rosiglitazone Maleate through this category.

About Rosiglitazone Maleate

Rosiglitazone Maleate is a prescription medication also sold under the brand name Avandia. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Rosiglitazone Maleate  ·  Brand name: Avandia.

See the full Rosiglitazone drug information

Related: does Rosiglitazone Maleate deplete any nutrients?

Rosiglitazone Maleate has 1 reported nutrient association in the research literature — see the Rosiglitazone Maleate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Rosiglitazone Maleate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Rosiglitazone Maleate.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Rosiglitazone Maleate & Supplements: Common Questions

What supplements interact with Rosiglitazone Maleate?
More than you might expect — 314 in total, though they are far from equal: 4 are rated major, 266 moderate, and 44 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Rosiglitazone Maleate supplement interactions are the most serious?
The 4 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Rosiglitazone Maleate?
Usually yes — most people on Rosiglitazone Maleate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Avandia have the same supplement interactions as Rosiglitazone Maleate?
Yes — Avandia all contain Rosiglitazone Maleate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Rosiglitazone Maleate deplete any vitamins or nutrients?
It might — Rosiglitazone Maleate has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Rosiglitazone Maleate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Rosiglitazone Maleate and my other medications?
This page covers Rosiglitazone Maleate against supplements and herbal ingredients. Checking Rosiglitazone Maleate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Rosiglitazone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.