Drug & supplement interaction

Black Psyllium + Rosiglitazone Maleate

Rosiglitazone Maleate brand name: Avandia.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Black Psyllium has a minor interaction with Rosiglitazone Maleate. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Black Psyllium and Rosiglitazone Maleate

Here is the interaction we found between these two, with the evidence behind it.

Minor

ORAL DRUGS

Why this applies to Rosiglitazone Maleate

Rosiglitazone Maleate falls under ORAL DRUGS — the group Black Psyllium interacts with.

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
Severity Minor Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: black psyllium is a gel-forming fiber, and when that gel sits in your gut it can grab onto pills and change how much gets absorbed. With rosiglitazone (Avandia), the concern is mostly theoretical and based on lower-quality data, so I don't want you to worry too much. The fiber could slightly lower or shift how much of your dose you take in, which in theory might make your blood sugar control a little less predictable.

The easy fix is timing. Take your rosiglitazone first, then wait about 30 to 60 minutes before your psyllium. That way the fiber isn't sitting on the medicine. Keep an eye on your usual blood sugar readings, and check with your pharmacist or doctor before changing anything.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  5. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  6. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  7. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  8. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  9. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Black Psyllium Also Interacts With Other Medications

Black Psyllium has 23 moderate, 2,001 minor known drug interactions in our database — the Rosiglitazone Maleate one above is one of them. If you take anything else, check it against the full list below.

Moderate 23 Minor 2,001 No known interaction 806 (incl. Rosiglitazone Maleate)
Taking anything else?

Check Another of Your Medications Against Black Psyllium

Covers the 2,830 medications we’ve checked against Black Psyllium. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Rosiglitazone Maleate

This page covers Black Psyllium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rosiglitazone Maleate page lists 314 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Acai (moderate).

By severity: 4 major · 266 moderate · 44 minor.

From our pharmacist’s overview on the Rosiglitazone Maleate page

“Rosiglitazone (Avandia) lowers blood sugar in type 2 diabetes, and most of the 314 supplements and herbs on this page pull on that same lever. Some 239 can move blood glucose on their own, so adding one risks hypoglycemia, the shakiness, sweating, and confusion of sugar falling too low.”

Reviewed by 2 · Jul 18, 2026

Open the Rosiglitazone Maleate interaction page

One more smart check

Taking Black Psyllium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 5 real supplement products containing Black Psyllium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Psyllium. Your product may carry other ingredients that interact with Rosiglitazone Maleate too, on top of Black Psyllium — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Black Psyllium and Rosiglitazone Maleate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Psyllium
Top half

#378 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rosiglitazone Maleate
Top 5%

#97 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Black Psyllium

What is Black Psyllium?

Black Psyllium
  • Constipation
  • Diarrhea
  • High cholesterol
  • Digestive health
  • Blood sugar support
  • Weight management

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for relieving constipation and may modestly help lower cholesterol, but it must always be taken with plenty of water. Talk with your pharmacist or doctor before starting, especially if you have swallowing problems or bowel disorders.

Read the full Black Psyllium monograph & all interactions
Medication

About Rosiglitazone

What Is Rosiglitazone Used For?

Brand name: Avandia

  • Rosiglitazone is used along with a diet and exercise program and sometimes with one or more other medications to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Rosiglitazone is in a class of medications called thiazolidinediones. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels. Rosiglitazone is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

See full Rosiglitazone drug information
Keep checking

Other Drugs & Black Psyllium

Browse every other medication we’ve checked against Black Psyllium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
23Moderate
2,001Minor
805No known interaction
23 Moderate 2,001 Minor 805 No interaction
Moderate

23 interactions

Minor

2,001 interactions

Showing 60 of 2,001 minor interactions — see all 2,001 on the Black Psyllium page.

No interaction 805 drugs checked — show the list

We also checked Black Psyllium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 805 medications checked with no known interaction — see the full Black Psyllium list.

See the full Black Psyllium interactions page
See every supplement checked against Rosiglitazone Maleate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Black Psyllium monograph › Uses, safety, and every drug interaction in one place Rosiglitazone Maleate supplement interactions › Every supplement checked against Rosiglitazone Maleate, ranked by severity Rosiglitazone drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Black Psyllium and Rosiglitazone Maleate Together: Common Questions

Can you take Black Psyllium with Rosiglitazone Maleate?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Black Psyllium and Rosiglitazone Maleate interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Rosiglitazone Maleate and Black Psyllium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.