Drug & supplement interaction

D-mannose + tipranavir

tipranavir brand name: Aptivus.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between D-mannose and tipranavir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for tipranavir states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

D-mannose and tipranavir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between tipranavir and D-mannose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for D-mannose at all — not against tipranavir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

D-mannose safety at a glance

D-mannose overall Use caution Generally well tolerated short-term, but high-quality long-term safety data are limited.
Pregnancy Use caution Not enough reliable safety data, so it is best to avoid unless your doctor advises otherwise.
Breastfeeding Use caution Safety while breastfeeding is not well studied, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining tipranavir and D-mannose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests D-mannose and tipranavir May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea / Diarrhea reported in 20.5% of FDA reports for tipranavir Additional detail

    D-mannose

    “Orally, D-mannose can cause loose stools, diarrhea, abdominal bloating, and nausea. In children, loose stools and abdominal bloating have been reported at D-mannose doses ranging from 100 mg/kg three times daily to 150 mg/kg five times daily. Diarrhea has been reported in adults taking D-mannose 2 grams daily for 6 months.”

    D-mannose · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 13344. Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
    2. 91141. Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
    3. 100979. Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
    4. 100981. . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
    5. 104209. Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
    6. 100977. de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed

    tipranavir

    Listed in the ADVERSE REACTIONS section of the FDA label for tipranavir, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for D-mannose but not commonly for tipranavir: bloating or gas.

Effects for tipranavir come from the ADVERSE REACTIONS section of its FDA label; effects for D-mannose come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,379 voluntary FDA FAERS reports for tipranavir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some tipranavir Products Have a Food Rule — D-mannose Should Not Break It

At least one FDA label for a product containing tipranavir says to take it with food. If you take D-mannose on an empty stomach out of habit, keep them separate — and take tipranavir with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two tipranavir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 ) APTIVUS taken with ritonavir tablets must be taken with meals ( 2.1 ) APTIVUS capsules must be swallowed whole and must not be opened or chewed ( 2.1 ) Children should be assessed for their ability to swallow capsules before prescribing APTIVUS capsules.

From the Dosage and Administration section of the FDA label we read for tipranavir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With tipranavir

This page covers D-mannose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the tipranavir page lists 212 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 165 moderate · 44 minor.

From our pharmacist’s overview on the tipranavir page

“Keeping tipranavir (Aptivus) at a steady blood level is what keeps HIV suppressed, so this is a supplement list that deserves genuine care, and the three major-rated entries come first. St.”

Reviewed by 2 · Jul 18, 2026

Open the tipranavir interaction page

How much people look this up

Where D-mannose and tipranavir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement D-mannose
Top half

#722 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication tipranavir
Steady interest

#2,040 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every D-mannose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The D-mannose and tipranavir records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About D-mannose

What is D-mannose?

D-mannose
  • Preventing urinary tract infections (UTIs)
  • Treating mild UTIs
  • Urinary tract health
  • Carbohydrate-deficient glycoprotein syndrome (a rare genetic condition)

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is still limited and it should not replace antibiotics for an active infection. Talk to your pharmacist or doctor before using it, particularly if you are pregnant, breastfeeding, or have diabetes.

Simple sugar (monosaccharide) derived from plants such as cranberries, apples, and other fruits and vegetables · Capsules, tablets, powder; often combined with cranberry

An interaction check asks whether these two react with each other — it does not ask whether D-mannose is a good idea for someone in your situation. Here is what our D-mannose record says about it on its own.

D-mannose: dosing

There is no official, standardized dose of D-mannose, and the amounts used in research have varied. Do not use D-mannose in place of prescribed antibiotics for an active infection.

From our D-mannose monograph — the full record covers uses, side effects and every documented interaction.

Read the full D-mannose monograph & all interactions
Medication

About Tipranavir

What Is Tipranavir Used For?

Brand name: Aptivus

Aptivus (tipranavir) is used to treat HIV-1 infection in adults and in pediatric patients weighing 36 kg or more who have already tried other HIV medications and whose virus has become resistant to more than one protease inhibitor. It must always be taken together with ritonavir to work properly.

Aptivus is not recommended for people who have never been treated for HIV before. It works best when combined with other active HIV medications, and a resistance test is usually done first to confirm the virus will respond to it.

See full Tipranavir drug information
Keep checking

Other Drugs & D-mannose

Browse every other medication we’ve checked against D-mannose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked D-mannose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full D-mannose list.

See the full D-mannose interactions page
See every supplement checked against tipranavir, ranked by severity
Evidence & sources

D-mannose References

The 6 references that drive our D-mannose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
  2. Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
  3. de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
  4. Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
  5. . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
  6. Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking D-mannose and tipranavir Together: Common Questions

Is it safe to take D-mannose with tipranavir?
We do not list a known interaction between D-mannose and tipranavir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do D-mannose and tipranavir have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take D-mannose and tipranavir at the same time of day?
At least one FDA label for a product containing tipranavir says to take it with food. If you take D-mannose on an empty stomach out of habit, keep them separate and take tipranavir with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two tipranavir products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does tipranavir interact with any supplements?
Yes. tipranavir has documented interactions with 212 supplements in our database — D-mannose is not one of them. The tipranavir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

D-mannose monograph Uses, safety profile, and every drug interaction in one place Tipranavir drug information The full plain-English guide to this medication tipranavir supplement interactions Every supplement checked against tipranavir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About tipranavir and D-mannose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.