Drug & supplement interaction

Dandelion + Aspirin, Caffeine, Codeine Phosphate

Aspirin, Caffeine, Codeine Phosphate brand name: Anacin w/ Codeine.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Aspirin, Caffeine, Codeine Phosphate falls into 2 drug categories that Dandelion can interact with; the most serious is rated moderate. Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Dandelion and Aspirin, Caffeine, Codeine Phosphate

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Dandelion interacts with whole categories of medication. Aspirin, Caffeine, Codeine Phosphate falls into 2 of those categories, so it can interact with Dandelion in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

1 of 2

Why this applies to Aspirin, Caffeine, Codeine Phosphate

Aspirin, Caffeine, Codeine Phosphate falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Dandelion interacts with.

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the piece that matters in your combo pill: the caffeine. Caffeine is cleared by a liver enzyme called CYP1A2, and lab studies hint that dandelion might slow that enzyme down. If that happened in real life, caffeine could hang around longer and build up, which might leave you feeling jittery, restless, or with a racing heart and trouble sleeping.

I want to be honest about the evidence though. This is only seen in test-tube and animal research, never reported in actual people, so it's more of a theoretical heads-up than a proven problem. Food amounts of dandelion are very unlikely to matter; concentrated supplements are the bigger question mark. If you take dandelion regularly, just run it by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

2 of 2

Aspirin, Caffeine, Codeine Phosphate also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combo product contains aspirin, which already thins your blood a bit by keeping platelets (the cells that form clots) from sticking together. The concern here is with the aspirin part. Some early lab research hints that dandelion root may also make platelets less sticky. If that effect carries over into real life, pairing the two could nudge up your odds of bruising, nosebleeds, or bleeding that's slow to stop.

I want to be honest about how thin this evidence is: it comes only from test-tube studies, not people, so it's theoretical. A little dandelion in food or tea is very unlikely to matter. Concentrated supplements are the bigger question. If you take this medicine regularly, just check with your pharmacist or doctor before adding dandelion.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Neef H, Cilli F, Declerck PJ, et al. Platelet anti-aggregating activity of Taraxacum officinale Weber. Phytotherapy Research 1996;10:s138-s140.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Dandelion Also Interacts With Other Medications

Dandelion has 456 moderate known drug interactions in our database — the Aspirin, Caffeine, Codeine Phosphate one above is among them. If you take anything else, check it against the full list below.

Moderate 456 No known interaction 2,374 (incl. Aspirin, Caffeine, Codeine Phosphate)
Taking anything else?

Check Another of Your Medications Against Dandelion

Covers the 2,830 medications we’ve checked against Dandelion. Pick one to open its full report.

From our Q&A

Questions About Dandelion or Aspirin, Caffeine, Codeine Phosphate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Dandelion or Aspirin, Caffeine, Codeine Phosphate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Aspirin, Caffeine, Codeine Phosphate

This page covers Dandelion only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Caffeine, Codeine Phosphate page lists 398 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 17 major · 334 moderate · 47 minor.

From our pharmacist’s overview on the Aspirin, Caffeine, Codeine Phosphate page

“Anacin with Codeine combines aspirin, caffeine, and codeine, and each of the three picks up its own supplement problems, so this is a list worth real caution. Just over half of the 398 ingredients here, 202 of them, can add to aspirin's blood-thinning action and raise bleeding risk.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Caffeine, Codeine Phosphate interaction page

One more smart check

Taking Dandelion as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,328 real supplement products containing Dandelion, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dandelion. Your product may carry other ingredients that interact with Aspirin, Caffeine, Codeine Phosphate too, on top of Dandelion — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dandelion and Aspirin, Caffeine, Codeine Phosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dandelion
Top 5%

#55 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Caffeine, Codeine Phosphate
Steady interest

#1,480 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Dandelion

What is Dandelion?

Dandelion
  • Water retention (diuretic)
  • Digestive upset
  • Liver and gallbladder support
  • Mild appetite stimulant
  • Skin conditions

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits are not well proven. It is generally considered safe as a food, but talk to your pharmacist or doctor before using concentrated supplements, especially if you have allergies or take other medicines.

Read the full Dandelion monograph & all interactions
Keep checking

Other Drugs & Dandelion

Browse every other medication we’ve checked against Dandelion — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
456Moderate
0Minor
2,373No known interaction
456 Moderate 2,373 No interaction
Moderate

456 interactions

Showing 60 of 456 moderate interactions — see all 456 on the Dandelion page.

No interaction 2,373 drugs checked — show the list

We also checked Dandelion against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,373 medications checked with no known interaction — see the full Dandelion list.

See the full Dandelion interactions page
See every supplement checked against Aspirin, Caffeine, Codeine Phosphate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Dandelion monograph › Uses, safety, and every drug interaction in one place Aspirin, Caffeine, Codeine Phosphate supplement interactions › Every supplement checked against Aspirin, Caffeine, Codeine Phosphate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Dandelion and Aspirin, Caffeine, Codeine Phosphate Together: Common Questions

Can you take Dandelion with Aspirin, Caffeine, Codeine Phosphate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Dandelion and Aspirin, Caffeine, Codeine Phosphate?
Aspirin, Caffeine, Codeine Phosphate belongs to more than one drug category, and Dandelion interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Dandelion and Aspirin, Caffeine, Codeine Phosphate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Caffeine, Codeine Phosphate and Dandelion?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.