Medication interaction hub

What Supplements Interact with Aspirin, Caffeine, Codeine Phosphate?

Aspirin, Caffeine, Codeine Phosphate brand name: Anacin w/ Codeine. Every interaction below applies to the brands too.

398 Interactions 17 Major 334 Moderate 47 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aspirin, Caffeine, Codeine Phosphate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aspirin, Caffeine, Codeine Phosphate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anacin with Codeine combines aspirin, caffeine, and codeine, and each of the three picks up its own supplement problems, so this is a list worth real caution. Just over half of the 398 ingredients here, 202 of them, can add to aspirin's blood-thinning action and raise bleeding risk. Another 78 deepen codeine's sedation, and 44 push caffeine's stimulant effects harder. Beer and wine are among the best-documented major risks because alcohol intensifies that sedation.

Seventeen entries carry a major rating, alongside 334 moderate and 47 minor, and those 17 are what to understand first. Grapefruit can push codeine levels up by blocking the CYP3A4 enzyme that clears it, while St. John's wort speeds that same enzyme and lowers drug levels instead. If you take anything sedating, mention it to your pharmacist, and keep activated charcoal well apart from doses because it soaks up medicine before it absorbs.

— , Clinical Pharmacist · July 18, 2026

Major 17 Moderate 334 Minor 47 No known interaction 1,054

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Caffeine, Codeine Phosphate: Top Interactions at a Glance

The Aspirin, Caffeine, Codeine Phosphate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 398 interacting ingredients — plus 1,054 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Caffeine, Codeine Phosphate Combinations Today

The Aspirin, Caffeine, Codeine Phosphate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Fish Oil + Aspirin, Caffeine, Codeine Phosphatei

Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Bromelain + Aspirin, Caffeine, Codeine Phosphatei

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Niacin + Aspirin, Caffeine, Codeine Phosphatei

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Unlikely Magnesium + Aspirin, Caffeine, Codeine Phosphatei

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full interaction Minor Likelihood Unlikely Acerola + Aspirin, Caffeine, Codeine Phosphatei

Theoretically, acerola might reduce the clearance of aspirin; however, its vitamin C content is likely too low to produce clinically significant effects.

Read the full interaction Moderate Likelihood Possible Saw Palmetto + Aspirin, Caffeine, Codeine Phosphatei

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Aspirin, Caffeine, Codeine Phosphate

All 1,452 ingredients in our database, ranked by severity — 398 with a Aspirin, Caffeine, Codeine Phosphate interaction on file and 1,054 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aspirin, Caffeine, Codeine Phosphate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Fish Oil with Aspirin, Caffeine, Codeine Phosphate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Fish Oil + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Bromelain with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Niacin with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Full Niacin + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Magnesium with Aspirin, Caffeine, Codeine Phosphate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Full Magnesium + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Acerola with Aspirin, Caffeine, Codeine Phosphate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, acerola might reduce the clearance of aspirin; however, its vitamin C content is likely too low to produce clinically signifi...

Full Acerola + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Sodium Bicarbonate with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may reduce the levels and clinical effects of aspirin.

Full Sodium Bicarbonate + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Syrian Rue with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Syrian Rue + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Tree Turmeric with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs that are substrates of CYP3A4.

Full Tree Turmeric + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Willow Bark with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Willow Bark + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Wintergreen with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Using wintergreen oil topically in large amounts, with occlusive dressings, or for prolonged periods of time might increase the risk of addi...

Full Wintergreen + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Yerba Mansa with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive or prolonged sedative effects.

Full Yerba Mansa + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Yerba Mate with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of stimulant drugs and yerba mate might increase stimulant adverse effects.

Full Yerba Mate + Aspirin, Caffeine, Codeine Phosphate answer

Can you take 1,3-dmaa with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,3-DMAA strongly inhibits cytochrome P450 2D6 (CYP2D6) enzymes in vitro.

Full 1,3-dmaa + Aspirin, Caffeine, Codeine Phosphate answer

Can you take 1,3-dmba with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining 1,3-DMBA with other stimulant drugs might increase the risk of cardiovascular toxicity.

Full 1,3-dmba + Aspirin, Caffeine, Codeine Phosphate answer

Can you take 1,4-dmaa with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. 1,4-DMAA is thought to have stimulant and vasoconstrictive effects, which have been demonstrated in animal studies.

Full 1,4-dmaa + Aspirin, Caffeine, Codeine Phosphate answer

Can you take 5-htp with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Full 5-htp + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Acacia Rigidula with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Acacia rigidula products that are adulterated with beta-methylphenylethylamine (BMPEA) might increase the levels of CYP2D6 su...

Full Acacia Rigidula + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Aconite with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining aconite with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.

Full Aconite + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Active Hexose Correlated Compound (ahcc) with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, AHCC might increase levels of drugs metabolized by CYP2D6.

Full Active Hexose Correlated Compound (ahcc) + Aspirin, Caffeine, Codeine Phosphate answer

Can you take Adrafinil with Aspirin, Caffeine, Codeine Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might reduce the levels and clinical effects of CYP1A2 substrates.

Full Adrafinil + Aspirin, Caffeine, Codeine Phosphate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Caffeine, Codeine Phosphate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Caffeine, Codeine Phosphate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Caffeine, Codeine Phosphate sits in 18 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Caffeine, Codeine Phosphate through this category.

Codeine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Aspirin, Caffeine, Codeine Phosphate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Aspirin, Caffeine, Codeine Phosphate through this category.

Related: does Aspirin, Caffeine, Codeine Phosphate deplete any nutrients?

Aspirin, Caffeine, Codeine Phosphate has 5 reported nutrient associations in the research literature — see the Aspirin, Caffeine, Codeine Phosphate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Caffeine, Codeine Phosphate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Caffeine, Codeine Phosphate.

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Pharmacist Counseling Corner

Aspirin, Caffeine, Codeine Phosphate & Supplements: Common Questions

What supplements interact with Aspirin, Caffeine, Codeine Phosphate?
More than you might expect — 398 in total, though they are far from equal: 17 are rated major, 334 moderate, and 47 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Aspirin, Caffeine, Codeine Phosphate supplement interactions are the most serious?
The 17 major-rated combinations — led by Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Caffeine, Codeine Phosphate?
Usually yes — most people on Aspirin, Caffeine, Codeine Phosphate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Anacin w/ Codeine have the same supplement interactions as Aspirin, Caffeine, Codeine Phosphate?
Yes — Anacin w/ Codeine all contain Aspirin, Caffeine, Codeine Phosphate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Caffeine, Codeine Phosphate deplete any vitamins or nutrients?
It might — Aspirin, Caffeine, Codeine Phosphate has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Caffeine, Codeine Phosphate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Caffeine, Codeine Phosphate and my other medications?
This page covers Aspirin, Caffeine, Codeine Phosphate against supplements and herbal ingredients. Checking Aspirin, Caffeine, Codeine Phosphate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.