Drug & supplement interaction

Dimethylsulfoxide (dmso) + Insulin Aspart

Insulin Aspart brand name: Fiasp.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Dimethylsulfoxide (dmso) and Insulin Aspart in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Dimethylsulfoxide (dmso) and Insulin Aspart

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Insulin Aspart and Dimethylsulfoxide (dmso) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dimethylsulfoxide (dmso) safety at a glance

Dimethylsulfoxide... overall Use caution Topical use can irritate skin and may carry impurities; only pharmaceutical-grade products should ever be used.
Pregnancy Avoid Safety has not been established, so it is best to avoid during pregnancy.
Breastfeeding Avoid There is not enough safety information, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Insulin Aspart and Dimethylsulfoxide (dmso)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Insulin Aspart

Interactions in our licensed database are recorded against drug classes, not just single drug names. Insulin Aspart is filed under a single classification — antidiabetes drugs. Dimethylsulfoxide (dmso) has documented interactions with 8 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), carboplatin (paraplatin) (moderate) and cholinergic drugs (moderate) — and none of Insulin Aspart’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dimethylsulfoxide (dmso) Does Interact With Other Medications

Dimethylsulfoxide (dmso) has 339 moderate known drug interactions in our database — Insulin Aspart isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Dimethylsulfoxide (dmso)

Covers the 2,830 medications we’ve checked against Dimethylsulfoxide (dmso). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Dimethylsulfoxide (dmso) and Insulin Aspart May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    Dimethylsulfoxide (dmso)

    “Topically, DMSO might cause dry or sore throat, cough, dry nasal passages, dyspnea, worsening of bronchial asthma, and an influenza-like syndrome.”

    Dimethylsulfoxide (dmso) · Natural Medicines adverse-effect record, reported in asthma.

    6 sources cited
    1. 6303. Rosenstein ED. Topical agents in the treatment of rheumatic disorders. Rheum Dis Clin North Am 1999;25:899-918. PubMed
    2. 6304. Trice JM, Pinals RS. Dimethyl sulfoxide: a review of its use in the rheumatic disorders. Semin Arthritis Rheum 1985;15:45-60. PubMed
    3. 6306. Merlini G. Treatment of primary amyloidosis. Semin Hematol 1995;32:60-79.
    4. 6308. Thiers BH. Unusual treatments for herpesvirus infections II, herpes zoster. J Am Acad Dermatol 1983;8:433-6. PubMed
    5. 6309. Burton WJ, Gould PW, Hursthouse MW, et al. A multicentre trial of Zostrum (5 percent idoxuridine in dimethyl sulphoxide) in herpes zoster. N Z Med J 1981;94:384-6.
    6. 6311. Juel Jensen BE, MacCallum FO, Mackenzie AM, Pike MC. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 1970;4:776-80. PubMed

    Insulin Aspart

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Aspart. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Dimethylsulfoxide (dmso)

    “Infusion of hematopoietic stem cells cryopreserved with DMSO might cause hypertension with tachycardia, bradycardia, chest tightness, and ventricular extrasystoles. Intravenously, DMSO can cause vasodilation, facial flushing, hypotension, chest pains, and sinus tachycardia.”

    Dimethylsulfoxide (dmso) · Natural Medicines adverse-effect record, reported in hypertension.

    6 sources cited
    1. 5695. Barker SB, Matthews PN, Philip PF, Williams G. Prospective study of intravesical dimethyl sulphoxide in the treatment of chronic inflammatory bladder disease. Br J Urol 1987;59:142-4. PubMed
    2. 5696. Fowler JE Jr. Prospective study of intravesical dimthyl sulfoxide in treatment of suspected early interstitial cystitis. Urology 1981;18:21-6.
    3. 5697. Shirley SW, Stewart BH, Mirelman S. Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. Urology 1978;11:215-20. PubMed
    4. 6318. Rowley SD. Hematopoietic stem cell processing and cryopreservation. J Clin Apheresis 1992;7:132-4. PubMed
    5. 6320. Zambelli A, Poggi G, Da Prada G, et al. Clinical toxicity of cryopreserved circulation progenitor cells infusion. Anticancer Res 1998;18:4705-8.
    6. 6300. Marshall LF, Camp PE, Bowers SA. Dimethyl sulfoxide for the treatment of intracranial hypertension: a preliminary trial. Neurosurg 1984;14:659-63. DOI

    Insulin Aspart

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Aspart. Read the label on DailyMed ›

  • Fever Additional detail

    Dimethylsulfoxide (dmso)

    “Infusion of hematopoietic stem cells cryopreserved with DMSO can cause fever.

    Garlic-like taste, breath, and garlic-onion-oyster body odor may be experienced with all routes of administration.”

    Dimethylsulfoxide (dmso) · Natural Medicines adverse-effect record, reported in body odor.

    6 sources cited
    1. 5695. Barker SB, Matthews PN, Philip PF, Williams G. Prospective study of intravesical dimethyl sulphoxide in the treatment of chronic inflammatory bladder disease. Br J Urol 1987;59:142-4. PubMed
    2. 5696. Fowler JE Jr. Prospective study of intravesical dimthyl sulfoxide in treatment of suspected early interstitial cystitis. Urology 1981;18:21-6.
    3. 5697. Shirley SW, Stewart BH, Mirelman S. Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. Urology 1978;11:215-20. PubMed
    4. 6318. Rowley SD. Hematopoietic stem cell processing and cryopreservation. J Clin Apheresis 1992;7:132-4. PubMed
    5. 6320. Zambelli A, Poggi G, Da Prada G, et al. Clinical toxicity of cryopreserved circulation progenitor cells infusion. Anticancer Res 1998;18:4705-8.
    6. 10625. Hucker HB, Ahmad PM, Miller EA, et al. Metabolism of dimethyl sulphoxide to dimethyl sulphone in the rat and man. Nature 1966;209:619-20. PubMed

    Insulin Aspart

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Aspart. Read the label on DailyMed ›

  • Itching Additional detail

    Dimethylsulfoxide (dmso)

    “Topically, DMSO can cause erythema, pruritus, burning, blistering, and drying and scaling skin. Skin reactions are usually reversible after discontinuing the drug.”

    Dimethylsulfoxide (dmso) · Natural Medicines adverse-effect record, reported in erythema.

    6 sources cited
    1. 6303. Rosenstein ED. Topical agents in the treatment of rheumatic disorders. Rheum Dis Clin North Am 1999;25:899-918. PubMed
    2. 6304. Trice JM, Pinals RS. Dimethyl sulfoxide: a review of its use in the rheumatic disorders. Semin Arthritis Rheum 1985;15:45-60. PubMed
    3. 6306. Merlini G. Treatment of primary amyloidosis. Semin Hematol 1995;32:60-79.
    4. 6308. Thiers BH. Unusual treatments for herpesvirus infections II, herpes zoster. J Am Acad Dermatol 1983;8:433-6. PubMed
    5. 6309. Burton WJ, Gould PW, Hursthouse MW, et al. A multicentre trial of Zostrum (5 percent idoxuridine in dimethyl sulphoxide) in herpes zoster. N Z Med J 1981;94:384-6.
    6. 6311. Juel Jensen BE, MacCallum FO, Mackenzie AM, Pike MC. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 1970;4:776-80. PubMed

    Insulin Aspart

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Aspart. Read the label on DailyMed ›

  • Diarrhea / Vomiting / Nausea reported in 5.9% of FDA reports for Insulin Aspart Additional detail

    Dimethylsulfoxide (dmso)

    “Topically, DMSO might cause nausea, vomiting, diarrhea, constipation, and anorexia.

    Infusion of hematopoietic stem cells cryopreserved with DMSO might cause nausea, vomiting, and abdominal cramps.”

    Dimethylsulfoxide (dmso) · Natural Medicines adverse-effect record, reported in anorexia.

    6 sources cited
    1. 6303. Rosenstein ED. Topical agents in the treatment of rheumatic disorders. Rheum Dis Clin North Am 1999;25:899-918. PubMed
    2. 6304. Trice JM, Pinals RS. Dimethyl sulfoxide: a review of its use in the rheumatic disorders. Semin Arthritis Rheum 1985;15:45-60. PubMed
    3. 6306. Merlini G. Treatment of primary amyloidosis. Semin Hematol 1995;32:60-79.
    4. 6308. Thiers BH. Unusual treatments for herpesvirus infections II, herpes zoster. J Am Acad Dermatol 1983;8:433-6. PubMed
    5. 6309. Burton WJ, Gould PW, Hursthouse MW, et al. A multicentre trial of Zostrum (5 percent idoxuridine in dimethyl sulphoxide) in herpes zoster. N Z Med J 1981;94:384-6.
    6. 6311. Juel Jensen BE, MacCallum FO, Mackenzie AM, Pike MC. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 1970;4:776-80. PubMed

    Insulin Aspart

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Aspart, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Headache Additional detail

    Dimethylsulfoxide (dmso)

    “Topically, DMSO might cause sedation, headache, dizziness, and drowsiness.

    Intravenously, DMSO might cause weakness, confusion, lethargy, disorientation, agitation, dysarthria, hypoactive reflexes, decreased consciousness, and encephalopathy.

    Infusion of hematopoietic stem cells cryopreserved with DMSO might cause rigors and chills.”

    Dimethylsulfoxide (dmso) · Natural Medicines adverse-effect record, reported in cluster headache.

    6 sources cited
    1. 6303. Rosenstein ED. Topical agents in the treatment of rheumatic disorders. Rheum Dis Clin North Am 1999;25:899-918. PubMed
    2. 6304. Trice JM, Pinals RS. Dimethyl sulfoxide: a review of its use in the rheumatic disorders. Semin Arthritis Rheum 1985;15:45-60. PubMed
    3. 6306. Merlini G. Treatment of primary amyloidosis. Semin Hematol 1995;32:60-79.
    4. 6308. Thiers BH. Unusual treatments for herpesvirus infections II, herpes zoster. J Am Acad Dermatol 1983;8:433-6. PubMed
    5. 6309. Burton WJ, Gould PW, Hursthouse MW, et al. A multicentre trial of Zostrum (5 percent idoxuridine in dimethyl sulphoxide) in herpes zoster. N Z Med J 1981;94:384-6.
    6. 6311. Juel Jensen BE, MacCallum FO, Mackenzie AM, Pike MC. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 1970;4:776-80. PubMed

    Insulin Aspart

    Listed in the ADVERSE REACTIONS section of the FDA label for Insulin Aspart. Read the label on DailyMed ›

Reported for Dimethylsulfoxide (dmso) but not commonly for Insulin Aspart: an irregular heartbeat, a fast or pounding heartbeat, stomach pain and chest pain.

Effects for Insulin Aspart come from the ADVERSE REACTIONS section of its FDA label; effects for Dimethylsulfoxide (dmso) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 65,752 voluntary FDA FAERS reports for Insulin Aspart that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Insulin Aspart

This page covers Dimethylsulfoxide (dmso) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Aspart page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Insulin Aspart page

“Every one of the 239 supplements listed for insulin aspart (Fiasp) touches the same thing the drug exists to manage, blood sugar, so this list warrants genuine care rather than a quick skim. Most entries add to insulin's glucose-lowering effect, raising the risk of hypoglycemia, and with a rapid-acting mealtime insulin a low can become…”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Aspart interaction page

How much people look this up

Where Dimethylsulfoxide (dmso) and Insulin Aspart Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dimethylsulfoxide (dmso)
Top half

#559 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Aspart
Top half

#969 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dimethylsulfoxide (dmso) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Dimethylsulfoxide (dmso) and Insulin Aspart records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dimethylsulfoxide (dmso)

What is Dimethylsulfoxide (dmso)?

Dimethylsulfoxide (dmso)
  • Muscle and joint pain
  • Arthritis
  • Sprains and strains
  • Interstitial cystitis (bladder pain)
  • Skin penetration enhancer for other medicines

DMSO is a colorless liquid solvent that people apply to the skin for pain and inflammation, and it is FDA-approved (as a prescription) only for interstitial cystitis placed directly into the bladder. Most over-the-counter uses for pain and arthritis have limited or low-quality evidence, and DMSO can carry impurities or push other chemicals through your skin. Talk to your pharmacist or doctor before using it, and avoid industrial-grade products.

Industrially produced chemical compound (a byproduct of wood pulp processing) · Topical cream, gel, liquid solution; bladder instillation solution (prescription); industrial-grade and pharmaceutical-grade liquids

An interaction check asks whether these two react with each other — it does not ask whether Dimethylsulfoxide (dmso) is a good idea for someone in your situation. Here is what our Dimethylsulfoxide (dmso) record says about it on its own.

Dimethylsulfoxide (dmso): dosing

There is no single standardized over-the-counter dose of DMSO for pain or arthritis.

From our Dimethylsulfoxide (dmso) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dimethylsulfoxide (dmso) monograph & all interactions
Medication

About Insulin Aspart (rDNA Origin) Injection

What Is Insulin Aspart (rDNA Origin) Injection Used For?

Brand name: Fiasp

Insulin aspart is used to improve blood sugar (glucose) control in people with diabetes mellitus. It is approved for both type 1 and type 2 diabetes in adults, and for diabetes mellitus in pediatric patients.

Insulin Aspart Protamine and Insulin Aspart Mix 70/30 is a pre-mixed product that combines a rapid-acting and an intermediate-acting insulin aspart. It is approved to improve blood sugar control in adult patients with diabetes mellitus. It is not recommended for treating diabetic ketoacidosis, and because its ratio of rapid-acting to intermediate-acting insulin is fixed, it does not allow for separate mealtime versus background dose adjustments.

Most-Reported Side Effects for Insulin Aspart

From FAERS, the FDA’s public side-effect reporting system (65,752 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Blood glucose increased 10,660 reports
Nausea 3,902 reports
Blood glucose decreased 3,409 reports
Fatigue 2,749 reports
Diarrhea 2,661 reports
See full Insulin Aspart (rDNA Origin) Injection drug information
Keep checking

Other Drugs & Dimethylsulfoxide (dmso)

Browse every other medication we’ve checked against Dimethylsulfoxide (dmso) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
339Moderate
0Minor
2,490No known interaction
Moderate

339 interactions

Showing 60 of 339 moderate interactions — see all 339 on the Dimethylsulfoxide (dmso) page.

No interaction 2,490 drugs checked — show the list
Evidence & sources

Dimethylsulfoxide (dmso) References

The 27 references that drive our Dimethylsulfoxide (dmso) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ludwig CU, Stoll HR, Obrist R, Obrecht JP. Prevention of cytotoxic drug induced skin ulcers with dimethyl sulfoxide (DMSO) and alpha-tocopherol. Eur J Cancer Clin Oncol 1987;23:327-9.
  2. Barker SB, Matthews PN, Philip PF, Williams G. Prospective study of intravesical dimethyl sulphoxide in the treatment of chronic inflammatory bladder disease. Br J Urol 1987;59:142-4. PubMed
  3. Fowler JE Jr. Prospective study of intravesical dimthyl sulfoxide in treatment of suspected early interstitial cystitis. Urology 1981;18:21-6.
  4. Shirley SW, Stewart BH, Mirelman S. Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. Urology 1978;11:215-20. PubMed
  5. Marshall LF, Camp PE, Bowers SA. Dimethyl sulfoxide for the treatment of intracranial hypertension: a preliminary trial. Neurosurg 1984;14:659-63. DOI
  6. Karaca M, Bilgin UY, Akar M, de la Torre JC. Dimethyl sulphoxide lowers ICP after head trauma. Eur J Clin Pharmacol 1991;40:113-4.
  7. Rosenstein ED. Topical agents in the treatment of rheumatic disorders. Rheum Dis Clin North Am 1999;25:899-918. PubMed
  8. Trice JM, Pinals RS. Dimethyl sulfoxide: a review of its use in the rheumatic disorders. Semin Arthritis Rheum 1985;15:45-60. PubMed
  9. Merlini G. Treatment of primary amyloidosis. Semin Hematol 1995;32:60-79.
  10. Thiers BH. Unusual treatments for herpesvirus infections II, herpes zoster. J Am Acad Dermatol 1983;8:433-6. PubMed
  11. Burton WJ, Gould PW, Hursthouse MW, et al. A multicentre trial of Zostrum (5 percent idoxuridine in dimethyl sulphoxide) in herpes zoster. N Z Med J 1981;94:384-6.
  12. Juel Jensen BE, MacCallum FO, Mackenzie AM, Pike MC. Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials. Br Med J 1970;4:776-80. PubMed
  13. Wildenhoff KE, Esmann V, Ipsen J, Harving H, et al. Treatment of trigeminal and thoracic zoster with idoxuridine. Scand J Infect Dis 1981;13:257-62. PubMed
  14. Williams HJ, Furst DE, Dahl SL, et al. Double-blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis. Arthritis Rheum 1985;28:308-14. PubMed
  15. Takacs T, Montet JC. In vitro dissolution of cholesterol biliary stones. Gut 1995;37:157-8. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dimethylsulfoxide (dmso) and Insulin Aspart Together: Common Questions

Is it safe to take Dimethylsulfoxide (dmso) with Insulin Aspart?
We do not list a known interaction between Dimethylsulfoxide (dmso) and Insulin Aspart. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Dimethylsulfoxide (dmso) and Insulin Aspart have any of the same side effects?
Yes — our sources link each of them separately to 8 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Dimethylsulfoxide (dmso) and Insulin Aspart combination checked?
Interactions in our licensed database are recorded against drug classes. Insulin Aspart is filed under 1 classification, and Dimethylsulfoxide (dmso) has documented interactions with 8 drug classes — none of Insulin Aspart's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Dimethylsulfoxide (dmso) interact with any other medications?
Yes. Dimethylsulfoxide (dmso) has 339 documented drug interactions in our database — Insulin Aspart is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Insulin Aspart interact with any supplements?
Yes. Insulin Aspart has documented interactions with 239 supplements in our database — Dimethylsulfoxide (dmso) is not one of them. The Insulin Aspart interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin Aspart and Dimethylsulfoxide (dmso)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.