Drug & supplement interaction

Divi-divi + Nitrofurantoin

Nitrofurantoin brand names: Macrodantin, Furadantin, Furatoin, Macrobid.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Divi-divi and Nitrofurantoin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Nitrofurantoin states a food rule worth keeping to.

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Interaction report

Divi-divi and Nitrofurantoin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nitrofurantoin and Divi-divi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Divi-divi at all — not against Nitrofurantoin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Divi-divi safety at a glance

Divi-divi overall Not established There is little reliable human safety data for medicinal use of divi-divi.
Pregnancy Avoid Safety has not been established, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data exists for nursing, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nitrofurantoin and Divi-divi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Nitrofurantoin’s Own FDA Label Lists

This is not an interaction — none of it involves Divi-divi. These are the most notable effects listed in the ADVERSE REACTIONS section of Nitrofurantoin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • An electrolyte imbalance Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • High blood sugar Worth acting on
  • Shortness of breath Worth acting on mentioned in 6.3% of FDA reports for Nitrofurantoin
  • Confusion Worth acting on
  • A severe skin reaction Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • A low platelet count Worth acting on

Showing the 10 most notable of 36 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Nitrofurantoin. Read the label on DailyMed › Where a percentage is shown, it is the share of 22,743 voluntary FDA FAERS reports for Nitrofurantoin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Divi-divi’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Divi-divi side to compare — that is a limit of the record, not a statement that Divi-divi has no side effects.

How to take them

Some Nitrofurantoin Products Have a Food Rule — Divi-divi Should Not Break It

At least one FDA label for a product containing Nitrofurantoin says to take it with food. If you take Divi-divi on an empty stomach out of habit, keep them separate — and take Nitrofurantoin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Nitrofurantoin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Divi-divi or Nitrofurantoin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Divi-divi or Nitrofurantoin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Nitrofurantoin

This page covers Divi-divi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nitrofurantoin page lists 82 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 68 moderate · 10 minor.

From our pharmacist’s overview on the Nitrofurantoin page

“Nitrofurantoin (Macrobid, Macrodantin) treats urinary tract infections and can strain the liver on its own, which is why this interaction list deserves genuine care rather than a glance. Of the 82 ingredients on file, 38 can add their own liver stress on top of the drug's, and three of the four major-rated entries fall in that group, i…”

Reviewed by 2 · Jul 18, 2026

Open the Nitrofurantoin interaction page

One more smart check

Taking Divi-divi as Part of a Dietary Supplement Product? Check It for Interactions

We hold 20 real supplement products containing Divi-divi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Divi-divi. Even though Divi-divi itself has no known interaction with Nitrofurantoin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Divi-divi and Nitrofurantoin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Divi-divi
Steady interest

#946 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nitrofurantoin
Top half

#854 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Divi-divi is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Divi-divi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Divi-divi and Nitrofurantoin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Divi-divi

What is Divi-divi?

  • Source of tannins for tanning leather
  • Traditional astringent for skin
  • Mouth and throat irritation (traditional gargles)
  • Wound and sore care (folk use)
  • Mild digestive complaints (folk use)

Divi-divi is a tropical tree whose tannin-rich seed pods have long been used in leather tanning and in traditional folk remedies, mostly as an astringent. There is very little modern human research to support any health benefit, so it should not be relied on to treat any medical condition. If you are considering it, talk with a pharmacist or doctor first.

Caesalpinia coriaria · Fabaceae · Seed pods (and sometimes bark) · Powdered pod extract, decoctions, and traditional topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Divi-divi is a good idea for someone in your situation. Here is what our Divi-divi record says about it on its own.

Divi-divi: dosing

There is no established or standardized medicinal dose for divi-divi. Traditional preparations vary widely and are not measured in a consistent way.If you choose to use a product that contains divi-divi, follow the directions on the label and do not exceed the suggested amount.

From our Divi-divi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Divi-divi monograph & all interactions
Medication

About Nitrofurantoin

What Is Nitrofurantoin Used For?

Brand names: Macrodantin, Furadantin, Furatoin, Macrobid

Nitrofurantoin treats urinary tract infections (UTIs) caused by specific susceptible bacteria. The capsule forms (including Macrodantin and nitrofurantoin macrocrystals capsules) are indicated for UTIs due to Escherichia coli, enterococci, Staphylococcus aureus, and certain strains of Klebsiella and Enterobacter species. Nitrofurantoin capsules (monohydrate/macrocrystals) are indicated only for acute uncomplicated UTIs (acute cystitis) caused by E. coli or Staphylococcus saprophyticus.

Nitrofurantoin oral suspension (Furadantin) is indicated for adults and children 1 month of age and older for UTIs caused by susceptible strains of E. coli, Enterococcus species, S. aureus, Klebsiella species, and Enterobacter species. No form of nitrofurantoin is approved for kidney infections (pyelonephritis) or infections in the tissue surrounding the kidneys (perinephric abscesses).

Most-Reported Side Effects for Nitrofurantoin

From FAERS, the FDA’s public side-effect reporting system (22,743 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Urinary tract infection 2,221 reports
Fatigue 1,839 reports
Nausea 1,827 reports
Headache 1,705 reports
Dyspnea 1,437 reports
See full Nitrofurantoin drug information
Keep checking

Other Drugs & Divi-divi

Browse every other medication we’ve checked against Divi-divi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Divi-divi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Divi-divi list.

See the full Divi-divi interactions page
See every supplement checked against Nitrofurantoin, ranked by severity
Evidence & sources

Divi-divi References

The 1 sources that drive our Divi-divi monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Divi-divi is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Tannins — MedlinePlus / NIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Divi-divi and Nitrofurantoin Together: Common Questions

Is it safe to take Divi-divi with Nitrofurantoin?
We do not list a known interaction between Divi-divi and Nitrofurantoin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Divi-divi and Nitrofurantoin at the same time of day?
At least one FDA label for a product containing Nitrofurantoin says to take it with food. If you take Divi-divi on an empty stomach out of habit, keep them separate and take Nitrofurantoin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Nitrofurantoin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Nitrofurantoin interact with any supplements?
Yes. Nitrofurantoin has documented interactions with 82 supplements in our database — Divi-divi is not one of them. The Nitrofurantoin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Divi-divi monograph Uses, safety profile, and every drug interaction in one place Nitrofurantoin drug information The full plain-English guide to this medication Nitrofurantoin supplement interactions Every supplement checked against Nitrofurantoin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nitrofurantoin and Divi-divi?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.