Medication interaction hub

What Supplements Interact with Nitrofurantoin?

Nitrofurantoin brand names: Macrodantin, Furadantin, Furatoin, Macrobid. Every interaction below applies to the brands too.

82 Interactions 4 Major 68 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nitrofurantoin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nitrofurantoin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Nitrofurantoin (Macrobid, Macrodantin) treats urinary tract infections and can strain the liver on its own, which is why this interaction list deserves genuine care rather than a glance. Of the 82 ingredients on file, 38 can add their own liver stress on top of the drug's, and three of the four major-rated entries fall in that group, including Siberian cocklebur and alcohol in beer or wine.

The fourth major, activated charcoal, can soak up an oral dose before it works, one of 17 entries that affect how oral medicines are absorbed. Another 27 are probiotics and fermented milk products; nitrofurantoin is an antibiotic and can kill those live organisms if taken at the same time, so space the doses well apart. The rest, 68 moderate and 10 minor overall, mostly follow these same patterns. A course usually lasts only days, so pausing a questionable supplement for a week is an easy trade against liver harm.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 68 Minor 10 No known interaction 1,370

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Nitrofurantoin: Top Interactions at a Glance

The Nitrofurantoin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 82 interacting ingredients — plus 1,370 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Nitrofurantoin Combinations Today

The Nitrofurantoin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Kudzu + Nitrofurantoini

Theoretically, concomitant use might have additive hepatotoxic effects.

Read the full interaction Major Likelihood Probable Wine + Nitrofurantoini

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Moderate Likelihood Probable Bacillus Subtilis + Nitrofurantoini

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Unlikely Green Tea + Nitrofurantoini

Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Nitrofurantoini

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Read the full interaction Moderate Likelihood Probable Limosilactobacillus Fermentum + Nitrofurantoini

Theoretically, taking Limosilactobacillus fermentum with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction
The complete list

Every Supplement Checked Against Nitrofurantoin

All 1,452 ingredients in our database, ranked by severity — 82 with a Nitrofurantoin interaction on file and 1,370 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nitrofurantoin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Kudzu with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + Nitrofurantoin answer

Can you take Wine with Nitrofurantoin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Wine + Nitrofurantoin answer

Can you take Bacillus Subtilis with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Full Bacillus Subtilis + Nitrofurantoin answer

Can you take Green Tea with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Green Tea + Nitrofurantoin answer

Can you take Ashwagandha with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Nitrofurantoin answer

Can you take Activated Charcoal with Nitrofurantoin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Nitrofurantoin answer

Can you take Beer with Nitrofurantoin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Beer + Nitrofurantoin answer

Can you take Bacillus Coagulans with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Nitrofurantoin answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Nitrofurantoin answer

Can you take Bifidobacterium Bifidum with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Nitrofurantoin answer

Can you take Bifidobacterium Breve with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Nitrofurantoin answer

Can you take Bifidobacterium Longum with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Nitrofurantoin answer

Can you take Coffee Charcoal with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Nitrofurantoin answer

Can you take European Mandrake with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Nitrofurantoin answer

Can you take Fermented Milk with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Nitrofurantoin answer

Can you take Glucomannan with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Nitrofurantoin answer

Can you take Lacticaseibacillus Casei with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Casei + Nitrofurantoin answer

Can you take Lacticaseibacillus Paracasei with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus paracasei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Paracasei + Nitrofurantoin answer

Can you take Lacticaseibacillus Rhamnosus with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Rhamnosus + Nitrofurantoin answer

Can you take Lactiplantibacillus Pentosus with Nitrofurantoin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Pentosus + Nitrofurantoin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nitrofurantoin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nitrofurantoin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nitrofurantoin sits in 3 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Nitrofurantoin through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Nitrofurantoin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Nitrofurantoin through this category.

About Nitrofurantoin

Nitrofurantoin is an antibiotic used to treat urinary tract infections caused by bacteria.

Generic name: Nitrofurantoin  ·  Brand names: Macrodantin, Furadantin, Furatoin, Macrobid.

See the full Nitrofurantoin drug information

Related: does Nitrofurantoin deplete any nutrients?

Nitrofurantoin has 28 reported nutrient associations in the research literature — see the Nitrofurantoin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nitrofurantoin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nitrofurantoin.

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Pharmacist Counseling Corner

Nitrofurantoin & Supplements: Common Questions

What supplements interact with Nitrofurantoin?
In our interaction database, 82 supplement and herbal ingredients have an interaction with Nitrofurantoin on file — 4 rated major, 68 moderate, and 10 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Nitrofurantoin supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Nitrofurantoin?
That depends entirely on which supplement. The honest answer for Nitrofurantoin is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Macrodantin have the same supplement interactions as Nitrofurantoin?
Yes — Macrodantin, Furadantin, Furatoin, Macrobid all contain Nitrofurantoin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Nitrofurantoin deplete any vitamins or nutrients?
It might — Nitrofurantoin has 28 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Nitrofurantoin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Nitrofurantoin and my other medications?
This page covers Nitrofurantoin against supplements and herbal ingredients. Checking Nitrofurantoin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Nitrofurantoin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.