Drug & supplement interaction

Dymethazine + Phenazopyridine, Sulfisoxazole

Phenazopyridine, Sulfisoxazole brand name: Azo-Gantrisin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Dymethazine and Phenazopyridine, Sulfisoxazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Dymethazine and Phenazopyridine, Sulfisoxazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phenazopyridine, Sulfisoxazole and Dymethazine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Dymethazine at all — not against Phenazopyridine, Sulfisoxazole, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dymethazine safety at a glance

Dymethazine overall Avoid Dymethazine is a designer anabolic steroid with serious liver and hormonal risks and is best avoided entirely.
Pregnancy Possibly Unsafe When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss,... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss,... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phenazopyridine, Sulfisoxazole and Dymethazine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Dymethazine Itself Has Been Linked To

This is not an interaction — nothing below involves Phenazopyridine, Sulfisoxazole. It is the side-effect record for Dymethazine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Dymethazine, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    “There is a case of cholestatic jaundice with elevated liver enzymes, dark urine, clay stools, and pruritus in a 26-year-old male, likely related to the use of a product (Super DMZ Rx 2.0) containing methylstenbolone 10 mg and dymethazine 10 mg per capsule. The product was used at manufacturer-recommended doses of two capsules daily for up to one month. Liver enzyme levels gradually decreased after discontinuation.”

    Dymethazine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 108298. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed
  • Kidney problems Worth acting on Additional detail

    “Orally, dymethazine is possibly unsafe. As an anabolic androgenic steroid, there is concern that it might cause serious side effects including stroke, kidney failure, and liver injury.”

    Dymethazine · Natural Medicines adverse-effect record, reported in kidney failure.

  • Liver problems Worth acting on Additional detail

    Recorded for Dymethazine in the same Natural Medicines adverse-effect record shown under Kidney problems above.

  • Itching Additional detail

    Recorded for Dymethazine in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes above.

Everything above comes from the Natural Medicines adverse-effect record for Dymethazine — expand a row for the licensed statement it rests on. We haven’t matched Phenazopyridine, Sulfisoxazole to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Phenazopyridine, Sulfisoxazole.

Special populations

Dymethazine in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Phenazopyridine, Sulfisoxazole

This page covers Dymethazine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenazopyridine, Sulfisoxazole page lists 68 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Para-aminobenzoic Acid (paba) (major), Alfalfa (moderate), Angelica Archangelica (moderate) and Arrach (moderate).

By severity: 2 major · 55 moderate · 11 minor.

From our pharmacist’s overview on the Phenazopyridine, Sulfisoxazole page

“Azo-Gantrisin pairs sulfisoxazole, a sulfa antibiotic, with phenazopyridine to ease urinary pain, and I'd want anyone taking it to pause before adding supplements. Two of the 68 ingredients on file rate major, and both can undercut the treatment itself: PABA feeds bacteria the raw material the sulfa drug is built to block, and activate…”

Reviewed by 2 · Jul 18, 2026

Open the Phenazopyridine, Sulfisoxazole interaction page

One more smart check

Taking Dymethazine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18 real supplement products containing Dymethazine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dymethazine. Even though Dymethazine itself has no known interaction with Phenazopyridine, Sulfisoxazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dymethazine and Phenazopyridine, Sulfisoxazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dymethazine
Steady interest

#745 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phenazopyridine, Sulfisoxazole
Steady interest

#1,944 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dymethazine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Dymethazine and Phenazopyridine, Sulfisoxazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dymethazine

What is Dymethazine?

  • Muscle building
  • Strength gains
  • Bodybuilding bulking cycles
  • Performance enhancement

Dymethazine is a synthetic anabolic-androgenic steroid (a so-called 'prohormone' or 'designer steroid'), not a true dietary supplement or herb. It carries serious health risks including liver damage and hormonal disruption, is banned in sports, and is not approved or recommended for use. We strongly advise against taking it.

Synthetic anabolic-androgenic steroid (not a plant) · Capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Dymethazine is a good idea for someone in your situation. Here is what our Dymethazine record says about it on its own.

Dymethazine: dosing

There is no established or recommended safe dose for Dymethazine, because it is not an approved medicine or a legitimate dietary supplement. We do not provide dosing for it.Because it is an anabolic steroid with real health risks, the safest amount is none.

From our Dymethazine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dymethazine monograph & all interactions
Keep checking

Other Drugs & Dymethazine

Browse every other medication we’ve checked against Dymethazine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Dymethazine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Dymethazine list.

See the full Dymethazine interactions page
See every supplement checked against Phenazopyridine, Sulfisoxazole, ranked by severity
Evidence & sources

Dymethazine References

The 2 references that drive our Dymethazine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dymethazine and Phenazopyridine, Sulfisoxazole Together: Common Questions

Is it safe to take Dymethazine with Phenazopyridine, Sulfisoxazole?
We do not list a known interaction between Dymethazine and Phenazopyridine, Sulfisoxazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Phenazopyridine, Sulfisoxazole interact with any supplements?
Yes. Phenazopyridine, Sulfisoxazole has documented interactions with 68 supplements in our database — Dymethazine is not one of them. The Phenazopyridine, Sulfisoxazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dymethazine monograph Uses, safety profile, and every drug interaction in one place Phenazopyridine, Sulfisoxazole supplement interactions Every supplement checked against Phenazopyridine, Sulfisoxazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phenazopyridine, Sulfisoxazole and Dymethazine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.