Medication interaction hub

What Supplements Interact with Phenazopyridine, Sulfisoxazole?

Phenazopyridine, Sulfisoxazole brand name: Azo-Gantrisin. Every interaction below applies to the brands too.

68 Interactions 2 Major 55 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Phenazopyridine, Sulfisoxazole? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Phenazopyridine, Sulfisoxazole against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Azo-Gantrisin pairs sulfisoxazole, a sulfa antibiotic, with phenazopyridine to ease urinary pain, and I'd want anyone taking it to pause before adding supplements. Two of the 68 ingredients on file rate major, and both can undercut the treatment itself: PABA feeds bacteria the raw material the sulfa drug is built to block, and activated charcoal can soak up the medication before it's absorbed. Either could leave a urinary infection undertreated.

Most of the 55 moderate entries follow two patterns. Twenty ingredients add to the sun sensitivity sulfa antibiotics already cause, making a serious burn more likely. Another large cluster is probiotics the antibiotic simply kills off, wasted money more than danger, and spacing those doses well apart mostly solves it. Bulky fibers like glucomannan can blunt absorption of anything swallowed, and 11 minor entries fill out the rest. PABA is one to stop entirely for the duration of treatment.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 55 Minor 11 No known interaction 1,384

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Phenazopyridine, Sulfisoxazole: Top Interactions at a Glance

The most significant Phenazopyridine, Sulfisoxazole supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 68 interacting ingredients — plus 1,384 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Phenazopyridine, Sulfisoxazole + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Para-aminobenzoic Acid (paba) + Phenazopyridine, Sulfisoxazolei

Theoretically, concomitant use of PABA and sulfonamide antibiotics inhibits the antibacterial effects of sulfonamide.

Read the full interaction Major Likelihood Probable Activated Charcoal + Phenazopyridine, Sulfisoxazolei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Phenazopyridine, Sulfisoxazole

All 1,452 ingredients in our database, ranked by severity — 68 with a Phenazopyridine, Sulfisoxazole interaction on file and 1,384 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Phenazopyridine, Sulfisoxazole?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Wild Carrot with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Wild Carrot + Phenazopyridine, Sulfisoxazole answer

Can you take Chenopodium Oil with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chenopodium oil with other photosensitizing drugs can increase the risk of adverse effects.

Full Chenopodium Oil + Phenazopyridine, Sulfisoxazole answer

Can you take Activated Charcoal with Phenazopyridine, Sulfisoxazole?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Phenazopyridine, Sulfisoxazole answer

Can you take Bergamot with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.

Full Bergamot + Phenazopyridine, Sulfisoxazole answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Phenazopyridine, Sulfisoxazole answer

Can you take Bifidobacterium Bifidum with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Phenazopyridine, Sulfisoxazole answer

Can you take Bifidobacterium Breve with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Phenazopyridine, Sulfisoxazole answer

Can you take Bifidobacterium Longum with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Phenazopyridine, Sulfisoxazole answer

Can you take Chlorophyll with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.

Full Chlorophyll + Phenazopyridine, Sulfisoxazole answer

Can you take Chlorophyllin with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.

Full Chlorophyllin + Phenazopyridine, Sulfisoxazole answer

Can you take Coffee Charcoal with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Phenazopyridine, Sulfisoxazole answer

Can you take European Mandrake with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Phenazopyridine, Sulfisoxazole answer

Can you take Fermented Milk with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Phenazopyridine, Sulfisoxazole answer

Can you take Glucomannan with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Phenazopyridine, Sulfisoxazole answer

Can you take Lacticaseibacillus Casei with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Casei + Phenazopyridine, Sulfisoxazole answer

Can you take Lacticaseibacillus Paracasei with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus paracasei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Paracasei + Phenazopyridine, Sulfisoxazole answer

Can you take Lacticaseibacillus Rhamnosus with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Rhamnosus + Phenazopyridine, Sulfisoxazole answer

Can you take Lactiplantibacillus Pentosus with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Pentosus + Phenazopyridine, Sulfisoxazole answer

Can you take Lactiplantibacillus Plantarum with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Plantarum + Phenazopyridine, Sulfisoxazole answer

Can you take Lactobacillus Acidophilus with Phenazopyridine, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Acidophilus + Phenazopyridine, Sulfisoxazole answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Phenazopyridine, Sulfisoxazole is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Phenazopyridine, Sulfisoxazole, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Phenazopyridine, Sulfisoxazole sits in 4 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Phenazopyridine, Sulfisoxazole through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Phenazopyridine, Sulfisoxazole through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Phenazopyridine, Sulfisoxazole through this category.

Sulfonamide Antibiotics 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Phenazopyridine, Sulfisoxazole through this category.

Related: does Phenazopyridine, Sulfisoxazole deplete any nutrients?

Phenazopyridine, Sulfisoxazole has 7 reported nutrient associations in the research literature — see the Phenazopyridine, Sulfisoxazole nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Phenazopyridine, Sulfisoxazole

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Phenazopyridine, Sulfisoxazole.

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Pharmacist Counseling Corner

Phenazopyridine, Sulfisoxazole & Supplements: Common Questions

What supplements interact with Phenazopyridine, Sulfisoxazole?
More than you might expect — 68 in total, though they are far from equal: 2 are rated major, 55 moderate, and 11 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Para-aminobenzoic Acid (paba), Activated Charcoal, Bacillus Coagulans.
Which Phenazopyridine, Sulfisoxazole supplement interactions are the most serious?
The 2 major-rated combinations — led by Para-aminobenzoic Acid (paba) and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Phenazopyridine, Sulfisoxazole?
Usually yes — most people on Phenazopyridine, Sulfisoxazole can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Azo-Gantrisin have the same supplement interactions as Phenazopyridine, Sulfisoxazole?
Yes — Azo-Gantrisin all contain Phenazopyridine, Sulfisoxazole, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Phenazopyridine, Sulfisoxazole deplete any vitamins or nutrients?
It might — Phenazopyridine, Sulfisoxazole has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Phenazopyridine, Sulfisoxazole nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Phenazopyridine, Sulfisoxazole and my other medications?
This page covers Phenazopyridine, Sulfisoxazole against supplements and herbal ingredients. Checking Phenazopyridine, Sulfisoxazole against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.