Drug & supplement interaction

Chlorophyllin + Phenazopyridine, Sulfisoxazole

Phenazopyridine, Sulfisoxazole brand name: Azo-Gantrisin.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Chlorophyllin has a moderate interaction with Phenazopyridine, Sulfisoxazole. Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Chlorophyllin and Phenazopyridine, Sulfisoxazole

Here is the interaction we found between these two, with the evidence behind it.

Moderate

PHOTOSENSITIZING DRUGS

Why this applies to Phenazopyridine, Sulfisoxazole

Phenazopyridine, Sulfisoxazole falls under PHOTOSENSITIZING DRUGS — the group Chlorophyllin interacts with.

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.
Severity Moderate Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: Azo-Gantrisin combines phenazopyridine (a urinary pain reliever) with sulfisoxazole (a sulfa antibiotic). The sulfa part is a well-known photosensitizer, meaning it can make your skin react more strongly to sunlight and burn more easily. Chlorophyllin may also cause a bit of sun sensitivity on its own, so taking both could add up and leave your skin extra prone to burning or rashes.

This is mostly a theoretical concern based on limited reports, so don't panic. Just be smart about sun exposure: wear sunscreen, cover up, and limit time in strong sunlight while on this combination. If you notice unusual redness, blistering, or a rash, check in with your pharmacist or doctor before continuing.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
  2. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
  3. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Chlorophyllin Also Interacts With Other Medications

Chlorophyllin has 334 moderate known drug interactions in our database — the Phenazopyridine, Sulfisoxazole one above is one of them. If you take anything else, check it against the full list below.

Moderate 334 No known interaction 2,496 (incl. Phenazopyridine, Sulfisoxazole)
Taking anything else?

Check Another of Your Medications Against Chlorophyllin

Covers the 2,830 medications we’ve checked against Chlorophyllin. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Phenazopyridine, Sulfisoxazole

This page covers Chlorophyllin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenazopyridine, Sulfisoxazole page lists 68 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Para-aminobenzoic Acid (paba) (major), Alfalfa (moderate), Angelica Archangelica (moderate) and Arrach (moderate).

By severity: 2 major · 55 moderate · 11 minor.

From our pharmacist’s overview on the Phenazopyridine, Sulfisoxazole page

“Azo-Gantrisin pairs sulfisoxazole, a sulfa antibiotic, with phenazopyridine to ease urinary pain, and I'd want anyone taking it to pause before adding supplements. Two of the 68 ingredients on file rate major, and both can undercut the treatment itself: PABA feeds bacteria the raw material the sulfa drug is built to block, and activate…”

Reviewed by 2 · Jul 18, 2026

Open the Phenazopyridine, Sulfisoxazole interaction page

One more smart check

Taking Chlorophyllin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 357 real supplement products containing Chlorophyllin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chlorophyllin. Your product may carry other ingredients that interact with Phenazopyridine, Sulfisoxazole too, on top of Chlorophyllin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chlorophyllin and Phenazopyridine, Sulfisoxazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chlorophyllin
Top half

#461 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phenazopyridine, Sulfisoxazole
Top 10%

#218 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Chlorophyllin

What is Chlorophyllin?

Chlorophyllin
  • Body and breath odor control
  • Wound and skin care
  • Internal deodorant for ostomy or incontinence
  • Detoxification claims
  • Digestive support

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a deodorizing agent, while many popular claims like detoxification and digestive benefits are not well proven. It is generally considered safe for short-term use, but talk to your pharmacist or doctor before starting it, especially during pregnancy or breastfeeding.

Read the full Chlorophyllin monograph & all interactions
Keep checking

Other Drugs & Chlorophyllin

Browse every other medication we’ve checked against Chlorophyllin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
334Moderate
0Minor
2,495No known interaction
334 Moderate 2,495 No interaction
Moderate

334 interactions

Showing 60 of 334 moderate interactions — see all 334 on the Chlorophyllin page.

No interaction 2,495 drugs checked — show the list

We also checked Chlorophyllin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,495 medications checked with no known interaction — see the full Chlorophyllin list.

See the full Chlorophyllin interactions page
See every supplement checked against Phenazopyridine, Sulfisoxazole, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Chlorophyllin monograph › Uses, safety, and every drug interaction in one place Phenazopyridine, Sulfisoxazole supplement interactions › Every supplement checked against Phenazopyridine, Sulfisoxazole, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Chlorophyllin and Phenazopyridine, Sulfisoxazole Together: Common Questions

Can you take Chlorophyllin with Phenazopyridine, Sulfisoxazole?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Chlorophyllin and Phenazopyridine, Sulfisoxazole interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Phenazopyridine, Sulfisoxazole and Chlorophyllin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.