Drug & supplement interaction

Chlorophyllin + Hydroxyurea

Hydroxyurea brand names: Droxia, Hydrea, Siklos, Xromi.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Chlorophyllin and Hydroxyurea in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chlorophyllin and Hydroxyurea

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydroxyurea and Chlorophyllin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chlorophyllin safety at a glance

Chlorophyllin overall Use caution Generally well tolerated short-term, but quality evidence and long-term safety data are limited.

Pregnancy Avoid Not enough reliable safety data, so it is best to avoid use during pregnancy.

Breastfeeding Avoid Safety while breastfeeding is unknown, so avoidance is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydroxyurea and Chlorophyllin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Hydroxyurea

Interactions in our licensed database are recorded against drug classes, not just single drug names. Hydroxyurea is filed under 2 classifications — antineoplastics, oral drugs. Chlorophyllin has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Hydroxyurea’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chlorophyllin Does Interact With Other Medications

Chlorophyllin has 335 moderate known drug interactions in our database — Hydroxyurea isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Hydroxyurea)

Taking anything else?

Check Another of Your Medications Against Chlorophyllin

Covers the 2,830 medications we’ve checked against Chlorophyllin. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Chlorophyllin and Hydroxyurea May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

A skin rash Additional detail
Chlorophyllin
“Since chlorophyllin is a semi-synthetic derivative of chlorophyll, there is some concern that it could cause similar adverse effects. Topically, chlorophyll cream has been reported to cause dermatitis. Orally, chlorophyll can cause photosensitization. In case reports, oral consumption of chlorophyll has been associated with the development of pseudoporphyria.”

Chlorophyllin · Natural Medicines adverse-effect record, reported in dermatitis.
5 sources cited

41912. Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.

1326. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed

93892. Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed

97933. Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed

101235. Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed
Hydroxyurea

Listed in the ADVERSE REACTIONS section of the FDA label for Hydroxyurea. Read the label on DailyMed ›

Reported for Chlorophyllin but not commonly for Hydroxyurea: sun sensitivity.

Effects for Hydroxyurea come from the ADVERSE REACTIONS section of its FDA label; effects for Chlorophyllin come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 21,027 voluntary FDA FAERS reports for Hydroxyurea that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Hydroxyurea Is Prescribed For, and What Chlorophyllin Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Hydroxyurea is a prescription medicine with approved uses on its FDA label. Chlorophyllin is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Hydroxyurea is prescribed for: Hydroxyurea is used for several serious conditions. Droxia, Siklos, and Xromi are each indicated to reduce the frequency of painful crises and reduce the need for blood transfusions in patients with sickle cell anemia who have recurrent moderate to severe painful crises. Siklos is approved for adults and children 2 years and older; Xromi is approved for children 6 months and older; Droxia is approved for adults. Hydrea capsules and Hydroxyurea capsules are indicated for resistant chronic myeloid leukemia and for locally advanced squamous cell carcinomas of the head and neck (excluding the lip) when used together with chemoradiation.

Chlorophyllin has been studied for:

Cancer studied, not established Chlorophyllin has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Chlorophyllin for cancer

Although there is interest in using oral chlorophyllin for cancer, there is insufficient reliable information about the clinical effects of chlorophyllin for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Hydroxyurea on your own; if you are taking Chlorophyllin for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Chlorophyllin or Hydroxyurea

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Chlorophyllin or Hydroxyurea, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydroxyurea

This page covers Chlorophyllin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydroxyurea page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 10 minor.

From our pharmacist’s overview on the Hydroxyurea page

“People take hydroxyurea (Droxia, Hydrea, Siklos, Xromi) for serious reasons, most often sickle cell disease or certain blood cancers, and it only works if a steady dose reaches the bloodstream. That is exactly what nearly all 18 supplements listed here can undermine, so this page earns real vigilance rather than a skim.”

Reviewed by 2 · Jul 18, 2026

Open the Hydroxyurea interaction page

One more smart check

Taking Chlorophyllin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 357 real supplement products containing Chlorophyllin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chlorophyllin. Even though Chlorophyllin itself has no known interaction with Hydroxyurea, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chlorophyllin and Hydroxyurea Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chlorophyllin

Steady interest

#801 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Hydroxyurea

Top 5%

#40 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chlorophyllin reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chlorophyllin and Hydroxyurea records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Chlorophyllin

What is Chlorophyllin?

Body and breath odor control
Wound and skin care
Internal deodorant for ostomy or incontinence
Detoxification claims
Digestive support

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a deodorizing agent, while many popular claims like detoxification and digestive benefits are not well proven. It is generally considered safe for short-term use, but talk to your pharmacist or doctor before starting it, especially during pregnancy or breastfeeding.

Semi-synthetic derivative of chlorophyll (originally from green plant leaves) · Tablets, capsules, liquid drops, topical ointments and sprays

An interaction check asks whether these two react with each other — it does not ask whether Chlorophyllin is a good idea for someone in your situation. Here is what our Chlorophyllin record says about it on its own.

Chlorophyllin: dosing

There is no official standardized dose for chlorophyllin, and the amount used in studies has varied. Products come in different strengths and forms, so the right amount depends on the specific product and how it is being used.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Chlorophyllin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chlorophyllin monograph & all interactions

Medication

About Hydroxyurea

What Is Hydroxyurea Used For?

Brand names: Droxia, Hydrea, Siklos, Xromi

Hydroxyurea is used for several serious conditions. Droxia, Siklos, and Xromi are each indicated to reduce the frequency of painful crises and reduce the need for blood transfusions in patients with sickle cell anemia who have recurrent moderate to severe painful crises. Siklos is approved for adults and children 2 years and older; Xromi is approved for children 6 months and older; Droxia is approved for adults.

Hydrea capsules and Hydroxyurea capsules are indicated for resistant chronic myeloid leukemia and for locally advanced squamous cell carcinomas of the head and neck (excluding the lip) when used together with chemoradiation.

Most-Reported Side Effects for Hydroxyurea

From FAERS, the FDA’s public side-effect reporting system (21,027 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,548 reports

Sickle cell anaemia with crisis 1,486 reports

Diarrhea 1,408 reports

Nausea 1,306 reports

Headache 1,068 reports

See full Hydroxyurea drug information

Keep checking

Other Drugs & Chlorophyllin

Browse every other medication we’ve checked against Chlorophyllin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

335Moderate

0Minor

2,494No known interaction

335 Moderate 2,494 No interaction

Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Chlorophyllin page.

No interaction 2,494 drugs checked — show the list

We also checked Chlorophyllin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Chlorophyllin list.

See the full Chlorophyllin interactions page

See every supplement checked against Hydroxyurea, ranked by severity

Evidence & sources

Chlorophyllin References

The 6 references that drive our Chlorophyllin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Nahata MC, Slencsak CA, Kamp J. Effect of chlorophyllin on urinary odor in incontinent geriatric patients. Drug Intell Clin Pharm 1983;17:732-4. PubMed
Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chlorophyllin and Hydroxyurea Together: Common Questions

Is it safe to take Chlorophyllin with Hydroxyurea?

We do not list a known interaction between Chlorophyllin and Hydroxyurea. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Chlorophyllin and Hydroxyurea have any of the same side effects?

Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Chlorophyllin and Hydroxyurea used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Chlorophyllin in each. That is a conversation for your prescriber, especially if Hydroxyurea is being adjusted to a target.

How was the Chlorophyllin and Hydroxyurea combination checked?

Interactions in our licensed database are recorded against drug classes. Hydroxyurea is filed under 2 classifications, and Chlorophyllin has documented interactions with 1 drug class — none of Hydroxyurea's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Chlorophyllin interact with any other medications?

Yes. Chlorophyllin has 335 documented drug interactions in our database — Hydroxyurea is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Hydroxyurea interact with any supplements?

Yes. Hydroxyurea has documented interactions with 18 supplements in our database — Chlorophyllin is not one of them. The Hydroxyurea interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chlorophyllin monograph Uses, safety profile, and every drug interaction in one place Hydroxyurea drug information The full plain-English guide to this medication Hydroxyurea supplement interactions Every supplement checked against Hydroxyurea, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydroxyurea and Chlorophyllin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.