English Ivy + Propranolol Hydrochloride
Propranolol Hydrochloride brand name: Hemangeol.
Propranolol Hydrochloride falls into 2 drug categories that English Ivy can interact with; the most serious is rated moderate. Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
Read the full interaction reportEnglish Ivy and Propranolol Hydrochloride
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
English Ivy interacts with whole categories of medication. Propranolol Hydrochloride falls into 2 of those categories, so it can interact with English Ivy in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES
1 of 2Why this applies to Propranolol Hydrochloride
Propranolol Hydrochloride falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES — the group English Ivy interacts with.
In vitro research shows that English ivy inhibits CYP2C19 enzymes. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist: lab studies suggest English ivy may slow down a liver enzyme called CYP2C19, which is one of the pathways your body uses to break down propranolol. If that pathway is blocked, propranolol could build up a little more than expected. Propranolol isn't a prodrug, so more drug in the body means a stronger beta-blocker effect, things like a slower heart rate, lower blood pressure, or a sleepy, sluggish baby.
That said, this is purely a test-tube finding and hasn't actually been seen in people, so I wouldn't lose sleep over it. Since propranolol for infant hemangioma is carefully dosed, it's still worth a quick chat with your pediatrician or pharmacist before adding any ivy-containing cough product.
- Rehman SU, Kim IS, Choi MS, Kim SH, Zhang Y, Yoo HH. Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules. 2017;22(7). PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
2 of 2Propranolol Hydrochloride also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
In vitro research shows that English ivy inhibits CYP2D6 enzymes. So far, this interaction has not been reported in humans.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the basic idea with English ivy and propranolol. Your child's body uses a liver enzyme called CYP2D6 to help clear propranolol. In lab dish studies, English ivy appears to slow that same enzyme down. If that were to happen in a real person, propranolol could build up a bit and act stronger than expected.
With infants on propranolol for hemangioma, the things to watch for are a slower heart rate, low blood sugar (poor feeding, sleepiness, shakiness), or low blood pressure. I want to stress this is theoretical, seen only in test tubes and never reported in actual patients, so don't panic. Still, since this is a baby on a carefully dosed medicine, please check with your pediatrician or pharmacist before giving any English ivy cough product.
- Rehman SU, Kim IS, Choi MS, Kim SH, Zhang Y, Yoo HH. Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules. 2017;22(7). PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
English Ivy Also Interacts With Other Medications
English Ivy has 279 moderate known drug interactions in our database — the Propranolol Hydrochloride one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against English Ivy
We haven’t checked that one against English Ivy yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against English Ivy. Pick one to open its full report.
See Every Supplement That Interacts With Propranolol Hydrochloride
This page covers English Ivy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propranolol Hydrochloride page lists 236 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).
Taking English Ivy as Part of a Dietary Supplement Product? Check It for Interactions
We hold 118 real supplement products containing English Ivy, each one broken down to its full ingredient list — and combination products often carry several ingredients besides English Ivy. Your product may carry other ingredients that interact with Propranolol Hydrochloride too, on top of English Ivy — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where English Ivy and Propranolol Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#699 of 1,452 supplements looked up here in the last 7 days
#1,390 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About English Ivy
What is English Ivy?
- Cough and chest congestion
- Bronchitis
- Asthma symptoms
- Sore throat
- Skin irritation
English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many European herbal products. Some research suggests it may help with certain coughs, but the evidence is still limited and mixed. The raw plant is poisonous if eaten and can irritate skin, so only use properly prepared commercial products and check with your pharmacist first.
About Propranolol (Infantile Hemangioma)
What Is Propranolol (Infantile Hemangioma) Used For?
Brand name: Hemangeol
This intravenous (IV) form of propranolol is used in hospital settings to treat serious, life-threatening heart rhythm problems. It works on several types of abnormal rhythms, including those that happen during anesthesia or are caused by drug toxicity.
Specific uses include fast heart rhythms coming from the upper chambers of the heart (supraventricular tachycardia), dangerous rhythms caused by too much digitalis in the body, and certain fast rhythms triggered by excess stress hormones (catecholamines) during surgery.
Other Drugs & English Ivy
Browse every other medication we’ve checked against English Ivy — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
279 interactions
- Propranolol ›
- Lidocaine ›
- Verapamil ›
- Zopiclone ›
- Fentanyl ›
- Isotretinoin ›
- Oxycodone ›
- Phenytoin ›
- Carbamazepine ›
- Dextromethorphan ›
- Formoterol ›
- Morphine Sulfate ›
- Amphetamine ›
- Diazepam ›
- Lofepramine ›
- Nortriptyline ›
- Propoxyphene ›
- Tretinoin ›
- Aripiprazole ›
- Cyclobenzaprine ›
- Desipramine ›
- Doxepin ›
- Duloxetine ›
- Fluphenazine ›
- Omeprazole ›
- Pantoprazole ›
- Paroxetine ›
- Progesterone (prescription Drug) ›
- Timolol ›
- Tramadol ›
- Vortioxetine ›
- Warfarin Sodium ›
- Amiodarone ›
- Amphetamine Sulfate ›
- Aripiprazole Lauroxil ›
- Carisoprodol ›
- Carvedilol ›
- Chlorpromazine ›
- Chlorpropamide ›
- Clomipramine ›
- Clozapine ›
- Cyclophosphamide ›
- Desvenlafaxine ›
- Fluoxetine ›
- Fluvastatin ›
- Galantamine ›
- Hexobarbital ›
- Hydrocodone ›
- Hydrocodone Bitartrate ›
- Imipramine ›
- Meperidine ›
- Metoprolol ›
- Moclobemide ›
- Nebivolol ›
- Nilutamide ›
- Oxycodone Hydrochloride ›
- Paclitaxel ›
- Pindolol ›
- Propafenone ›
- Quetiapine ›
Showing 60 of 279 moderate interactions — see all 279 on the English Ivy page.
No interaction 2,550 drugs checked — show the list
We also checked English Ivy against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Acetaminophen ›
- Rosuvastatin ›
- Abemaciclib ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Valacyclovir ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Methotrexate ›
- Bendamustine ›
- Amlodipine Besylate ›
- Acyclovir ›
- Doxycycline ›
- Pregabalin ›
- Lamotrigine ›
- Azithromycin ›
- Gabapentin ›
- Clonazepam ›
- Methylene Blue ›
- Letrozole ›
- Naproxen ›
- Buspirone ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Candesartan Cilexetil ›
- Acetaminophen, Aspirin, Caffeine ›
- Dapsone ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cyclopentolate ›
- Cephalexin ›
- Atorvastatin Calcium ›
- Amoxicillin, Clavulanate Potassium ›
- Mannitol ›
- Roxithromycin ›
- Levetiracetam ›
- Ezetimibe ›
- Acetaminophen, Aspirin ›
- Levothyroxine Sodium ›
- Finasteride ›
Showing the 60 most looked-up of 2,550 medications checked with no known interaction — see the full English Ivy list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Propranolol Hydrochloride Is Linked to Lower Levels of One Nutrient
Natural Medicines records Propranolol Hydrochloride as a medicine that can lower these. This is not an interaction with English Ivy — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Propranolol Hydrochloride nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking English Ivy and Propranolol Hydrochloride Together: Common Questions
Can you take English Ivy with Propranolol Hydrochloride?
Why are there 2 interactions listed for English Ivy and Propranolol Hydrochloride?
How serious is the English Ivy and Propranolol Hydrochloride interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Propranolol Hydrochloride and English Ivy?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.