Medication interaction hub

What Supplements Interact with Propranolol?

Propranolol brand names: Inderal LA, Inderal, Angilol, Syprol, Inderal Injection, and others. Every interaction below applies to the brands too.

236 Interactions 5 Major 194 Moderate 37 Minor
Curated & coded by · Clinical Pharmacist · Updated October 6, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Propranolol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Propranolol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Propranolol (Inderal) slows the heart and lowers blood pressure, which is exactly why its 236-ingredient interaction list deserves genuine care. Five entries rate major, and those are the ones to understand first. Beyond them, roughly half the list can push blood pressure lower than intended, including everyday things like fish oil, while a large share can change how much propranolol stays in your blood by affecting the liver enzymes that clear it.

The major five deserve a closer look. A couple of toxic botanicals can drag heart rate and pressure dangerously low on top of the drug, tyramine pushes pressure up and works against it, and activated charcoal can soak up an oral dose before it absorbs, so keep charcoal well apart from your pill. The other 194 moderate and 37 minor entries mostly nudge rather than derail, though on a heart medicine the nudges add up.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 194 Minor 37 No known interaction 1,216

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Propranolol: Top Interactions at a Glance

The Propranolol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 236 interacting ingredients — plus 1,216 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Propranolol Combinations Today

The Propranolol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Ashwagandha + Propranololi

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Berberine + Propranololi

Theoretically, berberine might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Cannabis + Propranololi

Cannabis may increase levels of drugs metabolized by CYP2C19.

Read the full interaction Moderate Likelihood Probable Melatonin + Propranololi

Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19.

Read the full interaction Moderate Likelihood Possible Cocoa + Propranololi

Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable Cannabidiol (cbd) + Propranololi

Cannabidiol may increase levels of drugs metabolized by CYP2C19.

Read the full interaction
The complete list

Every Supplement Checked Against Propranolol

All 1,452 ingredients in our database, ranked by severity — 236 with a Propranolol interaction on file and 1,216 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Propranolol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ashwagandha with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Full Ashwagandha + Propranolol answer

Can you take Berberine with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Propranolol answer

Can you take Cannabis with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabis may increase levels of drugs metabolized by CYP2C19.

Full Cannabis + Propranolol answer

Can you take Melatonin with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19.

Full Melatonin + Propranolol answer

Can you take Cocoa with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.

Full Cocoa + Propranolol answer

Can you take Celery with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery seed extract might have additive effects with antihypertensive drugs.

Full Celery + Propranolol answer

Can you take Coca with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antihypertensive drugs.

Full Coca + Propranolol answer

Can you take Cod Liver Oil with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cod liver oil with antihypertensive drugs might increase the risk of hypotension.

Full Cod Liver Oil + Propranolol answer

Can you take Coffee Charcoal with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Propranolol answer

Can you take Docosahexaenoic Acid (dha) with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Full Docosahexaenoic Acid (dha) + Propranolol answer

Can you take Eicosapentaenoic Acid (epa) with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking EPA with antihypertensive drugs might increase the risk of hypotension.

Full Eicosapentaenoic Acid (epa) + Propranolol answer

Can you take European Mandrake with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Propranolol answer

Can you take Eurycoma Longifolia with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Eurycoma longifolia can reduce the levels and clinical effects of propranolol.

Full Eurycoma Longifolia + Propranolol answer

Can you take Evodia with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evodia might reduce the levels and clinical effects of CYP1A2 substrates through induction of CYP1A2.

Full Evodia + Propranolol answer

Can you take Fever Bark with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might alter the effects of antihypertensive drugs.

Full Fever Bark + Propranolol answer

Can you take Fish Oil with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Propranolol answer

Can you take Ginkgo with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP2C19.

Full Ginkgo + Propranolol answer

Can you take Glucomannan with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Propranolol answer

Can you take Goldenseal with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP2D6.

Full Goldenseal + Propranolol answer

Can you take Guggul with Propranolol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guggul might reduce the effects of propranolol.

Full Guggul + Propranolol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Propranolol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Propranolol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Propranolol sits in 9 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Propranolol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Propranolol through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Propranolol through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Propranolol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Propranolol through this category.

Propranolol (Inderal) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Propranolol through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Propranolol through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Propranolol through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Propranolol through this category.

About Propranolol

Propranolol IV is a beta-blocker given in hospital settings to treat serious, fast or irregular heart rhythms.

Generic name: Propranolol  ·  Brand names: Inderal LA, Inderal, Angilol, Syprol, Inderal Injection, Half-Inderal LA, Bedranol SR, Half Beta Prograne, Beta Prograne, Lopranol LA, Slo-Pro, InnoPran XL, Hemangeol.

See the full Propranolol (Cardiovascular) drug information

Related: does Propranolol deplete any nutrients?

Propranolol has 24 reported nutrient associations in the research literature — see the Propranolol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Propranolol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Propranolol.

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Pharmacist Counseling Corner

Propranolol & Supplements: Common Questions

What supplements interact with Propranolol?
More than you might expect — 236 in total, though they are far from equal: 5 are rated major, 194 moderate, and 37 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Propranolol supplement interactions are the most serious?
The 5 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Indian Snakeroot — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Propranolol?
Usually yes — most people on Propranolol can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Inderal LA have the same supplement interactions as Propranolol?
Yes — Inderal LA, Inderal, Angilol, Syprol, Inderal Injection and other brands all contain Propranolol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Propranolol deplete any vitamins or nutrients?
It might — Propranolol has 24 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Propranolol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Propranolol and my other medications?
This page covers Propranolol against supplements and herbal ingredients. Checking Propranolol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Propranolol (Cardiovascular) drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 6, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.