Drug & supplement interaction

Coffee + Propranolol

Propranolol brand names: Inderal LA, Inderal, Angilol, Syprol, Inderal Injection, and others.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Coffee and Propranolol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Coffee and Propranolol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Propranolol and Coffee in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coffee safety at a glance

Coffee overall Use caution Moderate intake is generally safe for healthy adults, but high amounts can cause side effects.

Pregnancy Possibly Safe When used orally in moderate amounts. Intake of caffeine from coffee and other sources should be monitored during pregnancy. Caffeine crosses the human placenta... Read the full pregnancy detail

Breastfeeding Possibly Safe When used orally. Drinking one or two caffeine-containing beverages daily during lactation is not associated with unacceptable levels of caffeine in human milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Propranolol and Coffee? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Propranolol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Propranolol is filed under 9 classifications — including beta-blockers, cytochrome p450 2c19 (cyp2c19) substrates, antihypertensive drugs. Coffee has documented interactions with 33 drug classes — the most serious being ephedrine (major), adenosine (adenocard) (moderate) and alendronate (fosamax) (moderate) — and none of Propranolol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Coffee Does Interact With Other Medications

Coffee has 8 major, 467 moderate, 116 minor known drug interactions in our database — Propranolol isn’t one of them. If you take anything else, check it against the full list below.

Major 8 Moderate 467 Minor 116 No known interaction 2,239 (incl. Propranolol)

Taking anything else?

Check Another of Your Medications Against Coffee

Covers the 2,830 medications we’ve checked against Coffee. Pick one to open its full report.

What to actually watch for

What Coffee Itself Has Been Linked To

This is not an interaction — nothing below involves Propranolol. It is the side-effect record for Coffee on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Coffee, this list is the first place to look. 6 entries are worth acting on rather than waiting out — marked below.

Dependence or withdrawal symptoms Worth acting on Additional detail
“Orally, coffee containing caffeine can cause anxiety. This is more likely with increasing intake of caffeine and in certain populations (e.g., children, elderly). With chronic use, especially in large amounts, habituation, tolerance, and psychological dependence can occur. Other researchers suggest symptoms such as depressed mood are typical of caffeine withdrawal.”

Coffee · Natural Medicines adverse-effect record, reported in anxiety.
6 sources cited

8042. Anon. Filtering the news about coffee. University of California, Berkeley Wellness Letter 2001:17:1-2.

13734. Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. DOI

3719. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. PubMed

13738. Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl) 2004;176:1-29. PubMed

2723. Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. PubMed

11839. Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol 2002;40:1257-61. PubMed
A stroke or mini-stroke / A heart attack / An irregular heartbeat Worth acting on Additional detail
“Orally, coffee containing caffeine can cause chest pain and premature heartbeat. These effects are more likely with increasing intake of caffeine and in certain populations (e.g., children, elderly). Excessive doses of caffeine can cause massive catecholamine release and subsequent sinus tachycardia.

Although acute administration of caffeine can cause increased blood pressure, regular consumption does not seem to inc…”

Coffee · Natural Medicines adverse-effect record, reported in arrhythmia.
6 sources cited

8042. Anon. Filtering the news about coffee. University of California, Berkeley Wellness Letter 2001:17:1-2.

111045. Marcus GM, Rosenthal DG, Nah G, et al. Acute effects of coffee consumption on health among ambulatory adults. N Engl J Med. 2023;388(12):1092-1100. PubMed

11832. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html. DOI

11838. Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3. PubMed

13734. Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. DOI

13735. Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15. PubMed
Bone thinning Worth acting on Additional detail
“Orally, there is preliminary evidence that use of greater than four cups of coffee daily can increase the risk of rheumatoid factor positive rheumatoid arthritis, but this association has not been confirmed.

Epidemiological evidence regarding the relationship between caffeine use and the risk for osteoporosis is contradictory. Caffeine can increase urinary excretion of calcium.”

Coffee · Natural Medicines adverse-effect record, reported in bone loss.
6 sources cited

6482. Heliovaara M, Aho K, Knekt P, et al. Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis. Ann Rheum Dis 2000;59:631-5. PubMed

2669. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. PubMed

10202. Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70. PubMed

11317. Massey LK, Whiting SJ. Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 1993;123:1611-4. PubMed

6025. Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61. PubMed

98806. Wikoff D, Welsh BT, Henderson R, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 2017;109:585-648. PubMed
Low potassium / High blood sugar Worth acting on Additional detail
“Orally, excessive doses of caffeine can cause massive catecholamine release and subsequent metabolic acidosis, hyperglycemia, and ketosis. Other symptoms include hypokalemia and respiratory alkalosis.

Some evidence shows that caffeine, a constituent of coffee, is associated with fibrocystic breast disease, breast cancer, and endometriosis in females; however, this is controversial since findings are conflicting.”

Coffee · Natural Medicines adverse-effect record, reported in breast cancer.
6 sources cited

13734. Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. DOI

11832. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html. DOI

11838. Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3. PubMed

13735. Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15. PubMed

8043. Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4. PubMed

8996. Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. PubMed
Pancreatitis Worth acting on Additional detail
“The association between consumption of coffee and pancreatic cancer is controversial. Coffee may increase the incidence of some types of pancreatic cancers, but it may decrease other types. Some studies do not support this association, especially in patients that have never smoked.”

Coffee · Natural Medicines adverse-effect record, reported in bladder cancer.
6 sources cited

8535. Jacobsen BK, Heuch I. Coffee, K-ras mutations and pancreatic cancer: a heterogeneous aetiology or an artefact? J Epidemiol Community Health 2000;54:654-5.

8536. Porta M, Malats N, Alguacil J, et al. Coffee, pancreatic cancer, and K-ras mutations: updating the research agenda. J Epidemiol Community Health 2000;54:656-9.

8537. Kuper HE, Mucci LA, Trichopoulos D. Coffee, pancreatic cancer, and the question of causation. J Epidemiol Community Health 2000;54:650-1.

8038. Michaud DS, Giovannucci E, Willett WC, et al. Coffee and alcohol consumption and risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev 2001;10:429-37.

8040. Tavani A, La Vecchia C. Coffee and cancer: a review of epidemiological studies, 1990-1999. Eur J Cancer Prev 2000;9:241-56.

93878. Turati F, Galeone C, Talamini R, et al. Coffee, decaffeinated coffee, tea, and pancreatic cancer risk: a pooled-analysis of two Italian case-control studies. Eur J Cancer Prev 2011;20(4):287-92. PubMed
Fainting / Confusion Worth acting on Additional detail
“Orally, coffee containing caffeine can cause agitation, headache, insomnia, and nervousness, . These effects are more likely with increasing intake of caffeine and in certain populations (e.g., children, elderly).

Combining ephedra with coffee can increase the risk of adverse effects, due to the caffeine contained in coffee.”

Coffee · Natural Medicines adverse-effect record, reported in cluster headache.
6 sources cited

8042. Anon. Filtering the news about coffee. University of California, Berkeley Wellness Letter 2001:17:1-2.

11832. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at: http://books.nap.edu/books/0309082587/html/index.html. DOI

11838. Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3. PubMed

13734. Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. DOI

13735. Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15. PubMed

2729. FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).

Showing the 10 most notable of 30 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Coffee — expand a row for the licensed statement it rests on. We haven’t matched Propranolol to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Propranolol.

Special populations

Coffee in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally in moderate amounts. Intake of caffeine from coffee and other sources should be monitored during pregnancy. Caffeine crosses the human placenta, but is not considered a teratogen. Fetal blood and tissue levels are similar to maternal concentrations. The use of caffeine during pregnancy is controversial; however, moderate consumption has not been associated with clinically important adverse fetal effects. However, some research has also found that intrauterine exposure to even modest amounts of caffeine, based on maternal blood levels during the first trimester, is associated with a shorter stature in children ages 4-8 years. In some studies, consuming amounts over 200 mg daily has been associated with a significantly increased risk of miscarriage. This increased risk may be most likely to occur in people with genotypes that confer a slow rate of caffeine metabolism. According to a review by Health Canada, and a subsequent large meta-analysis conducted in the US, most healthy pregnant patients can safely consume caffeine in doses up to 300 mg daily without an increased risk of spontaneous abortion, stillbirth, preterm birth, fetal growth retardation, or congenital malformations. Advise patients to keep caffeine consumption below 300 mg daily during pregnancy. This is similar to the amount of caffeine in about 3 cups of coffee. Keep in mind that only the amount of ADDED caffeine must be stated on product labels. The amount of caffeine found in ingredients such as coffee, which naturally contains caffeine, does not need to be provided. This can make it difficult to determine the total amount of caffeine in a given product.

Pregnancy Possibly Unsafe

When caffeinated coffee providing more than 300 mg of caffeine daily is consumed orally. Caffeine from coffee crosses the placenta, producing fetal blood concentrations similar to maternal levels. Consumption of caffeine in amounts over 300 mg daily is associated with a significantly increased risk of miscarriage in some studies. Advise patients to keep caffeine consumption from all sources below 300 mg daily during pregnancy. This is similar to the amount of caffeine in about 3 cups of coffee. High doses of caffeine throughout pregnancy have resulted in symptoms of caffeine withdrawal in newborn infants. High doses of caffeine have also been associated with spontaneous abortion, premature delivery, and low birth weight. Drinking more than 6 cups of coffee daily increases the risk of spontaneous abortion. Drinking 8 or more cups of coffee daily doubles the risk of stillbirth when compared with those who do not drink coffee during pregnancy.

Lactation Possibly Safe

When used orally. Drinking one or two caffeine-containing beverages daily during lactation is not associated with unacceptable levels of caffeine in human milk.

Lactation Possibly Unsafe

When used orally in large amounts. Caffeine from coffee can cause wakefulness or irritability in breast-fed infants. Caffeine can also cause feeding intolerance and gastrointestinal irritation in infants.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Propranolol Is Prescribed For, and What Coffee Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Propranolol is a prescription medicine with approved uses on its FDA label. Coffee is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Propranolol is prescribed for: This intravenous (IV) form of propranolol is used in hospital or clinical settings to treat dangerous heart rhythm problems. It is generally reserved for life-threatening arrhythmias (abnormal heart rhythms) or those that occur during anesthesia. Specific conditions it treats include fast heart rates coming from the upper chambers of the heart (supraventricular tachycardia), certain arrhythmias caused by digitalis toxicity, dangerous ventricular rhythms that haven't responded to other treatments, and fast heart rates caused by excess adrenaline-like substances during surgery.

Coffee has been studied for:

Heart failure Natural Medicines rates the evidence for Coffee: Possibly Effective Read what the research shows

Coffee for heart failure

Consumption of caffeinated coffee seems to reduce the long-term risk of heart failure in those without cardiovascular disease (CVD) at baseline.
Stroke studied, not established Coffee has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Coffee for stroke
It is unclear if coffee consumption, alone or in combination with tea, is beneficial for stroke, post-stroke dementia, all-cause mortality, or stroke-related mortality. The available research is conflicting.

Details: Several meta-analyses of population research in patients with and without cardiovascular disease (CVD) have found no association between coffee consumption and risk of stroke.
4 sources cited

104597. Stevens LM, Linstead E, Hall JL, Kao DP. Association between coffee intake and incident heart failure risk: A machine learning analysis of the FHS, the ARIC Study, and the CHS. Circ Heart Fail. 2021:CIRCHEARTFAILURE119006799. PubMed

104882. Ribeiro EM, Alves M, Costa J, Ferreira JJ, Pinto FJ, Caldeira D. Safety of coffee consumption after myocardial infarction: A systematic review and meta-analysis. Nutr Metab Cardiovasc Dis. 2020;30(12):2146-2158. PubMed

107204. Zhang Y, Yang H, Li S, Li WD, Wang Y. Consumption of coffee and tea and risk of developing stroke, dementia, and poststroke dementia: A cohort study in the UK Biobank. PLoS Med 2021;18(11):e1003830. PubMed

107828. Chan L, Hong CT, Bai CH. Coffee consumption and the risk of cerebrovascular disease: a meta-analysis of prospective cohort studies. BMC Neurol 2021;21(1):380. PubMed
Kidney failure studied, not established Coffee has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Coffee for kidney failure

It is unclear if consuming coffee is beneficial for preventing progression to kidney failure or reducing the risk of chronic kidney disease (CKD)-related death.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Propranolol on your own; if you are taking Coffee for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Propranolol

This page covers Coffee only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propranolol page lists 236 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).

By severity: 5 major · 194 moderate · 37 minor.

From our pharmacist’s overview on the Propranolol page

“Propranolol (Inderal) slows the heart and lowers blood pressure, which is exactly why its 236-ingredient interaction list deserves genuine care. Five entries rate major, and those are the ones to understand first.”

Reviewed by 2 · Jul 18, 2026

Open the Propranolol interaction page

One more smart check

Taking Coffee as Part of a Dietary Supplement Product? Check It for Interactions

We hold 716 real supplement products containing Coffee, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coffee. Even though Coffee itself has no known interaction with Propranolol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coffee and Propranolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coffee

Top 5%

#70 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Propranolol

Top 1%

#11 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coffee reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Coffee and Propranolol records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Coffee

What is Coffee?

Alertness and reducing fatigue
Mental focus and concentration
Athletic performance
Headache relief
Weight management

Coffee is a widely consumed beverage made from roasted coffee beans, valued mainly for its caffeine, which boosts alertness and energy. For most healthy adults, moderate coffee intake is generally safe and may have some health benefits, but too much can cause jitteriness, poor sleep, and a faster heartbeat. People who are pregnant, breastfeeding, or sensitive to caffeine should limit their intake and check with a doctor or pharmacist.

Coffea arabica · Rubiaceae · Roasted seeds (beans) of the coffee fruit · Brewed coffee, instant coffee, espresso, capsules, green coffee bean extract, decaffeinated coffee

An interaction check asks whether these two react with each other — it does not ask whether Coffee is a good idea for someone in your situation. Here is what our Coffee record says about it on its own.

Coffee: dosing

There is no single official dose for coffee as a supplement. Many health authorities suggest that up to about 400 milligrams of caffeine per day is moderate for most healthy adults, which is roughly a few cups of brewed coffee, but individual tolerance varies a lot.If you use coffee capsules or extracts, follow the directions on the product label, since caffeine content can differ widely between products.

From our Coffee monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coffee monograph & all interactions

Medication

About Propranolol (Cardiovascular)

What Is Propranolol (Cardiovascular) Used For?

Brand names: Inderal LA, Inderal, Angilol, Syprol, Inderal Injection, Half-Inderal LA, Bedranol SR, Half Beta Prograne, Beta Prograne, Lopranol LA, Slo-Pro, InnoPran XL

This intravenous (IV) form of propranolol is used in hospital or clinical settings to treat dangerous heart rhythm problems. It is generally reserved for life-threatening arrhythmias (abnormal heart rhythms) or those that occur during anesthesia.

Specific conditions it treats include fast heart rates coming from the upper chambers of the heart (supraventricular tachycardia), certain arrhythmias caused by digitalis toxicity, dangerous ventricular rhythms that haven't responded to other treatments, and fast heart rates caused by excess adrenaline-like substances during surgery.

See full Propranolol (Cardiovascular) drug information

Keep checking

Other Drugs & Coffee

Browse every other medication we’ve checked against Coffee — both the ones with a known interaction and the ones without. Select any drug for the full detail.

8Major

467Moderate

116Minor

2,238No known interaction

8 Major 467 Moderate 116 Minor 2,238 No interaction

Major

8 interactions

Moderate

467 interactions

Showing 60 of 467 moderate interactions — see all 467 on the Coffee page.

Minor

116 interactions

Showing 60 of 116 minor interactions — see all 116 on the Coffee page.

No interaction 2,238 drugs checked — show the list

We also checked Coffee against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,238 medications checked with no known interaction — see the full Coffee list.

See the full Coffee interactions page

See every supplement checked against Propranolol, ranked by severity

Evidence & sources

Coffee References

The 175 references that drive our Coffee monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
Lasswell WL Jr, Weber SS, Wilkins JM. In vitro interaction of neuroleptics and tricylic antidepressants with coffee, tea, and gallotannic acid. J Pharm Sci 1984;73:1056-8. PubMed
Kulhanek F, Linde OK, Meisenberg G. Precipitation of antipsychotic drugs in interaction with coffee or tea. Lancet 1979;2:1130.
Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. PubMed
Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
Grubben MJ, Boers GH, Blom HJ, et al. Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial. Am J Clin Nutr 2000;71:480-4. PubMed
Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. PubMed
Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. PubMed
Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. PubMed
The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.
Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med 1999;341:1639-44. PubMed
Eskenazi B. Caffeine—filtering the facts. N Engl J Med 1999;341:1688-9. PubMed
Fernandes O, Sabharwal M, Smiley T, et al. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Reprod Toxicol 1998;12:435-44. PubMed
Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. PubMed
Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. PubMed
Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. PubMed
FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: www.verity.fda.gov (Accessed 25 January 2000).
Margolin KA, Green MR. Polymicrobial enteric septicemia from coffee enemas. West J Med 1984;140:460.
Urgert R, Vliet TV, Zock PL, et al. Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers. Am J Clin Nutr 2000;72:1107-10. PubMed
Green S. A critique of the rationale for cancer treatment with coffee enemas and diet. JAMA 1992;268:3224-7. DOI
Shils ME, Herman MG. Unproved dietary claims in the treatment of patients with cancer. Bull N Y Acad Med 1982;58:323-39.
Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. PubMed
Bak AA, Grobbee DE. The effect of serum cholesterol levels of coffee brewed by filtering or boiling. N Engl J Med 1989;321:1432-7.
Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. PubMed
Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. PubMed
Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61. PubMed
American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. PubMed
Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9.
Heliovaara M, Aho K, Knekt P, et al. Coffee consumption, rheumatoid factor, and the risk of rheumatoid arthritis. Ann Rheum Dis 2000;59:631-5. PubMed
Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. PubMed
Brown BT. Treating cancer with coffee enemas and diet. JAMA 1993;269:1635-6. DOI
Ali M, Afzal M. A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins Leukot Med 1987;27:9-13. PubMed
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Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Propranolol Is Linked to Lower Levels of One Nutrient

Natural Medicines records Propranolol as a medicine that can lower these. This is not an interaction with Coffee — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

COENZYME Q10›

Read the full Propranolol nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking Coffee and Propranolol Together: Common Questions

Is it safe to take Coffee with Propranolol?

We do not list a known interaction between Coffee and Propranolol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Are Coffee and Propranolol used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Coffee in each. That is a conversation for your prescriber, especially if Propranolol is being adjusted to a target.

How was the Coffee and Propranolol combination checked?

Interactions in our licensed database are recorded against drug classes. Propranolol is filed under 9 classifications, and Coffee has documented interactions with 33 drug classes — none of Propranolol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Coffee interact with any other medications?

Yes. Coffee has 591 documented drug interactions in our database — Propranolol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Propranolol interact with any supplements?

Yes. Propranolol has documented interactions with 236 supplements in our database — Coffee is not one of them. The Propranolol interaction page linked on this page lists every one, ranked by severity.

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Coffee monograph Uses, safety profile, and every drug interaction in one place Propranolol (Cardiovascular) drug information The full plain-English guide to this medication Propranolol supplement interactions Every supplement checked against Propranolol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 175 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.