Drug & supplement interaction

False Unicorn + Lesinurad, Allopurinol

Lesinurad, Allopurinol brand name: Duzallo.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between False Unicorn and Lesinurad, Allopurinol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

False Unicorn and Lesinurad, Allopurinol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lesinurad, Allopurinol and False Unicorn in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

False Unicorn safety at a glance

False Unicorn overall Use caution Safety data in humans is limited, and large doses may cause stomach upset.

Pregnancy Likely Unsafe When used orally because it is a potential uterine stimulant. Read the full pregnancy detail

Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lesinurad, Allopurinol and False Unicorn? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Lesinurad, Allopurinol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lesinurad, Allopurinol is filed under 7 classifications — including antigout drugs, cytochrome p450 3a4 (cyp3a4) inducers, cytochrome p450 2c9 (cyp2c9) substrates. False Unicorn has documented interactions with 3 drug classes — the most serious being cytochrome p450 2d6 (cyp2d6) substrates (moderate), cytochrome p450 3a4 (cyp3a4) substrates (moderate) and lithium (moderate) — and none of Lesinurad, Allopurinol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

False Unicorn Does Interact With Other Medications

False Unicorn has 740 moderate known drug interactions in our database — Lesinurad, Allopurinol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 740 No known interaction 2,090 (incl. Lesinurad, Allopurinol)

Taking anything else?

Check Another of Your Medications Against False Unicorn

Covers the 2,830 medications we’ve checked against False Unicorn. Pick one to open its full report.

What to actually watch for

What False Unicorn Itself Has Been Linked To

This is not an interaction — nothing below involves Lesinurad, Allopurinol. It is the side-effect record for False Unicorn on its own, from the licensed Natural Medicines monograph. If something new turns up after you add False Unicorn, this list is the first place to look.

Vomiting / Nausea Additional detail
“Orally, false unicorn root seems to be generally well tolerated (12). Large doses have been reported to cause nausea and vomiting (4).”

False Unicorn · Natural Medicines adverse-effect record, reported in nausea and vomiting.
2 sources cited

12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
“Orally, large doses of false unicorn have been reported to cause nausea and vomiting (4).”

False Unicorn · Natural Medicines adverse-effect record, reported in nausea and vomiting.
1 source cited

4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

Everything above comes from the Natural Medicines adverse-effect record for False Unicorn — expand a row for the licensed statement it rests on. We haven’t matched Lesinurad, Allopurinol to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Lesinurad, Allopurinol.

Special populations

False Unicorn in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally because it is a potential uterine stimulant.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Lesinurad, Allopurinol

This page covers False Unicorn only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lesinurad, Allopurinol page lists 134 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 106 moderate · 23 minor.

From our pharmacist’s overview on the Lesinurad, Allopurinol page

“Kidney-harming herbs are the sharpest hazard on this page. Siberian cocklebur and asarabacca (often contaminated with aristolochic acid) both carry major ratings, and that matters because lesinurad, half of the Duzallo combination for gout, comes with its own kidney injury warning.”

Reviewed by 2 · Jul 18, 2026

Open the Lesinurad, Allopurinol interaction page

One more smart check

Taking False Unicorn as Part of a Dietary Supplement Product? Check It for Interactions

We hold 32 real supplement products containing False Unicorn, each one broken down to its full ingredient list — and combination products often carry several ingredients besides False Unicorn. Even though False Unicorn itself has no known interaction with Lesinurad, Allopurinol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where False Unicorn and Lesinurad, Allopurinol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement False Unicorn

Top half

#692 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Lesinurad, Allopurinol

Steady interest

#2,026 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every False Unicorn reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The False Unicorn and Lesinurad, Allopurinol records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About False Unicorn

What is False Unicorn?

Menstrual cramps
Menopausal symptoms
Female infertility support
Irregular periods
Digestive complaints

False Unicorn is a North American plant whose root has long been used in traditional medicine for women's reproductive and menstrual concerns. There is very little reliable human research to show it actually works, and safety has not been well studied, so it should be used with caution and never during pregnancy. Talk to your pharmacist or doctor before trying it.

Chamaelirium luteum · Melanthiaceae · Root and rhizome (underground parts) · Dried root, capsules, tinctures, liquid extracts, teas

An interaction check asks whether these two react with each other — it does not ask whether False Unicorn is a good idea for someone in your situation. Here is what our False Unicorn record says about it on its own.

False Unicorn: dosing

There is no established or standardized dose for False Unicorn. Traditional preparations vary widely, and the strength of commercial products differs from brand to brand.If you choose to use it, follow the directions on the product label and do not take more than recommended.

From our False Unicorn monograph — the full record covers uses, side effects and every documented interaction.

Read the full False Unicorn monograph & all interactions

Keep checking

Other Drugs & False Unicorn

Browse every other medication we’ve checked against False Unicorn — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

740Moderate

0Minor

2,089No known interaction

740 Moderate 2,089 No interaction

Moderate

740 interactions

Showing 60 of 740 moderate interactions — see all 740 on the False Unicorn page.

No interaction 2,089 drugs checked — show the list

We also checked False Unicorn against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,089 medications checked with no known interaction — see the full False Unicorn list.

See the full False Unicorn interactions page

See every supplement checked against Lesinurad, Allopurinol, ranked by severity

Evidence & sources

False Unicorn References

The 4 references that drive our False Unicorn monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Ho SH, Singh M, Holloway AC, Crankshaw DJ. The effects of commercial preparations of herbal supplements commonly used by women on the biotransformation of fluorogenic substrates by human cytochromes P450. Phytother Res. 2011;25(7):983-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking False Unicorn and Lesinurad, Allopurinol Together: Common Questions

Is it safe to take False Unicorn with Lesinurad, Allopurinol?

We do not list a known interaction between False Unicorn and Lesinurad, Allopurinol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the False Unicorn and Lesinurad, Allopurinol combination checked?

Interactions in our licensed database are recorded against drug classes. Lesinurad, Allopurinol is filed under 7 classifications, and False Unicorn has documented interactions with 3 drug classes — none of Lesinurad, Allopurinol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does False Unicorn interact with any other medications?

Yes. False Unicorn has 740 documented drug interactions in our database — Lesinurad, Allopurinol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Lesinurad, Allopurinol interact with any supplements?

Yes. Lesinurad, Allopurinol has documented interactions with 134 supplements in our database — False Unicorn is not one of them. The Lesinurad, Allopurinol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

False Unicorn monograph Uses, safety profile, and every drug interaction in one place Lesinurad, Allopurinol supplement interactions Every supplement checked against Lesinurad, Allopurinol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lesinurad, Allopurinol and False Unicorn?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.