Drug & supplement interaction

Fasting + Insulin Human, Sodium Chloride

Insulin Human, Sodium Chloride brand name: Myxredlin.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Insulin Human, Sodium Chloride falls into 2 drug categories that Fasting can interact with; the most serious is rated moderate. Fasting might increase the risk of hypoglycemia if used with antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Fasting and Insulin Human, Sodium Chloride

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Fasting interacts with whole categories of medication. Insulin Human, Sodium Chloride falls into 2 of those categories, so it can interact with Fasting in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIDIABETES DRUGS

1 of 2

Why this applies to Insulin Human, Sodium Chloride

Insulin Human, Sodium Chloride falls under ANTIDIABETES DRUGS — the group Fasting interacts with.

Fasting might increase the risk of hypoglycemia if used with antidiabetes drugs.
Hypoglycemic events have been reported during intermittent fasting, including in patients using antidiabetes drugs. The risk of having a hypoglycemic event is largest for patients taking insulin or sulfonylureas. The risk of hypoglycemic events seems to be lower for patients taking other antidiabetes drugs such as glucagon-like peptide-1 receptor agonist (GLP- 1RA), metformin, thiazolidinediones, dipeptidyl peptidase-4 inhibitors (DPP4 inhibitors), and sodium-glucose cotransporter-2 (SGLT2) inhibitors. Advise patients to monitor glucose levels closely. Dose or time adjustments may be necessary.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: insulin's whole job is to lower your blood sugar. When you fast and go without food, your blood sugar naturally drifts lower too. Stack those two together and you can end up with low blood sugar (hypoglycemia), which is the main concern here. With insulin this risk is real, not just theoretical, so it deserves your attention.

Watch for the classic warning signs: shakiness, sweating, a pounding heart, confusion, dizziness, or sudden hunger. If it drops too far it can become dangerous. Insulin is a precise medicine, so even a skipped meal can matter. Please don't change your insulin dose or start fasting on your own. Talk with your doctor or pharmacist first so they can adjust your dose or timing and tell you how to check your sugar safely.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Carter S, Clifton PM, Keogh JB. Effect of intermittent compared with continuous energy restricted diet on glycemic control in patients with Type 2 diabetes: A randomized noninferiority trial. JAMA Netw Open. 2018;1(3):e180756. PubMed
  2. Cioffi I, Evangelista A, Ponzo V, et al. Intermittent versus continuous energy restriction on weight loss and cardiometabolic outcomes: a systematic review and meta-analysis of randomized controlled trials. J Transl Med. 2018;16(1):371. PubMed
  3. Chowdhury A, Khan H, Lasker SS, Chowdhury TA. Fasting outcomes in people with diabetes and chronic kidney disease in East London during Ramadan 2018: The East London diabetes in Ramadan survey. Diabetes Res Clin Pract. 2019;152:166-170. PubMed
  4. Grajower MM, Horne BD. Clinical management of intermittent fasting in patients with diabetes mellitus. Nutrients. 2019;11(4):873. PubMed
  5. Ibrahim M, Davies MJ, Ahmad E, et al. Recommendations for management of diabetes during Ramadan: update 2020, applying the principles of the ADA/EASD consensus. BMJ Open Diabetes Res Care. 2020;8(1):e001248. PubMed
  6. Wang X, Li Q, Liu Y, Jiang H, Chen W. Intermittent fasting versus continuous energy-restricted diet for patients with type 2 diabetes mellitus and metabolic syndrome for glycemic control: A systematic review and meta-analysis of randomized controlled tria
Moderate

INSULIN

2 of 2
Fasting might increase the risk of hypoglycemia if used with insulin.
Hypoglycemic events have been reported during intermittent fasting. The risk of a hypoglycemic event seems to be highest in patients using insulin or sulfonylureas. Patients with type 2 diabetes and other comorbidities, or those with type 1 diabetes, should be strongly advised to avoid fasting while taking insulin. For patients taking insulin who insist on fasting, advise these patients to monitor glucose levels closely. Dose or time adjustments may be necessary.
Severity Moderate Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind: insulin works by pulling sugar out of your blood, and fasting naturally lowers your blood sugar too. Stack those two together and your sugar can drop too far, which we call hypoglycemia. That can leave you feeling shaky, sweaty, dizzy, confused, or very tired, and in serious cases it can be dangerous. This isn't because fasting changes how your body breaks insulin down, it's simply that both push your sugar in the same low direction.

The research here is real but modest, and these low-sugar events have been seen during intermittent fasting. If you have diabetes and use insulin, please don't start fasting on your own. Talk with your doctor or pharmacist first, since your dose or timing may need adjusting and close glucose checks would be important.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Carter S, Clifton PM, Keogh JB. Effect of intermittent compared with continuous energy restricted diet on glycemic control in patients with Type 2 diabetes: A randomized noninferiority trial. JAMA Netw Open. 2018;1(3):e180756. PubMed
  2. Cioffi I, Evangelista A, Ponzo V, et al. Intermittent versus continuous energy restriction on weight loss and cardiometabolic outcomes: a systematic review and meta-analysis of randomized controlled trials. J Transl Med. 2018;16(1):371. PubMed
  3. Chowdhury A, Khan H, Lasker SS, Chowdhury TA. Fasting outcomes in people with diabetes and chronic kidney disease in East London during Ramadan 2018: The East London diabetes in Ramadan survey. Diabetes Res Clin Pract. 2019;152:166-170. PubMed
  4. Grajower MM, Horne BD. Clinical management of intermittent fasting in patients with diabetes mellitus. Nutrients. 2019;11(4):873. PubMed
  5. Ibrahim M, Davies MJ, Ahmad E, et al. Recommendations for management of diabetes during Ramadan: update 2020, applying the principles of the ADA/EASD consensus. BMJ Open Diabetes Res Care. 2020;8(1):e001248. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Fasting Also Interacts With Other Medications

Fasting has 2 major, 205 moderate known drug interactions in our database — the Insulin Human, Sodium Chloride one above is among them. If you take anything else, check it against the full list below.

Major 2 Moderate 205 No known interaction 2,623 (incl. Insulin Human, Sodium Chloride)
Taking anything else?

Check Another of Your Medications Against Fasting

Covers the 2,830 medications we’ve checked against Fasting. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin Human, Sodium Chloride

This page covers Fasting only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Human, Sodium Chloride page lists 242 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Chelation Therapy Products (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 211 moderate · 29 minor.

From our pharmacist’s overview on the Insulin Human, Sodium Chloride page

“The two entries to understand first for Myxredlin (human insulin in sodium chloride) are Siberian cocklebur, which has caused severe hypoglycemia in humans, and EDTA chelation products, which can drop blood glucose sharply and may interfere with the insulin itself. Those are the only major-rated interactions among the 242 ingredients o…”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Human, Sodium Chloride interaction page

How much people look this up

Where Fasting and Insulin Human, Sodium Chloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fasting
Top half

#560 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Human, Sodium Chloride
Top 10%

#182 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Eating pattern

About Fasting

What is Fasting?

  • Weight loss
  • Blood sugar control
  • Heart health
  • Religious or spiritual practice
  • General wellness and longevity

Fasting means voluntarily going without food (and sometimes drink) for set periods. Some research suggests it may help with weight loss and blood sugar in certain people, but results vary and quality of evidence is mixed. It is not safe for everyone, so check with your doctor or pharmacist before starting—especially if you take medication or have a health condition.

Read the full Fasting monograph & all interactions
Medication

About Human Insulin Injection

What Is Human Insulin Injection Used For?

Brand name: Myxredlin

Novolin (human insulin injection) is used to improve glycemic control — meaning blood sugar management — in adults and children with diabetes mellitus.

Novolin 70/30 is a fixed-ratio mixture of intermediate-acting and short-acting human insulin. Because the ratio is fixed, it cannot be adjusted separately for background (basal) or mealtime (prandial) needs.

See full Human Insulin Injection drug information
Keep checking

Other Drugs & Fasting

Browse every other medication we’ve checked against Fasting — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
205Moderate
0Minor
2,622No known interaction
2 Major 205 Moderate 2,622 No interaction
Major

2 interactions

Moderate

205 interactions

Showing 60 of 205 moderate interactions — see all 205 on the Fasting page.

No interaction 2,622 drugs checked — show the list

We also checked Fasting against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Fasting list.

See the full Fasting interactions page
See every supplement checked against Insulin Human, Sodium Chloride, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Fasting monograph › Uses, safety, and every drug interaction in one place Insulin Human, Sodium Chloride supplement interactions › Every supplement checked against Insulin Human, Sodium Chloride, ranked by severity Human Insulin Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Following Fasting While Taking Insulin Human, Sodium Chloride: Common Questions

Can you follow Fasting while taking Insulin Human, Sodium Chloride?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Fasting and Insulin Human, Sodium Chloride?
Insulin Human, Sodium Chloride belongs to more than one drug category, and Fasting interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Fasting and Insulin Human, Sodium Chloride interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.