Drug & supplement interaction

Fly Agaric Mushroom + Cefaclor

Cefaclor brand names: Ceclor CD, Ceclor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Fly Agaric Mushroom and Cefaclor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cefaclor states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Fly Agaric Mushroom and Cefaclor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cefaclor and Fly Agaric Mushroom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Fly Agaric Mushroom at all — not against Cefaclor, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fly Agaric Mushroom safety at a glance

Fly Agaric Mushroo... overall Avoid This is a poisonous mushroom with toxic, mind-altering compounds and no proven medical benefit.
Pregnancy Unsafe When used orally due to its toxicity; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally due to its toxicity; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cefaclor and Fly Agaric Mushroom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Fly Agaric Mushroom and Cefaclor May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Confusion Worth acting on Additional detail

    Fly Agaric Mushroom

    “Orally, fly agaric mushroom is poisonous and can cause significant toxicity. Any benefits of therapy may not outweigh the risk of toxicity. Although accidental fly agaric mushroom poisoning is rare because of its distinctive appearance, heavy rains can wash away the distinctive white plaques, causing the mushroom to be mistaken for a different, edible species of mushroom (Amanita caesarea).

    Most Common Adverse Effect…”

    Fly Agaric Mushroom · Natural Medicines adverse-effect record, reported in cardiac arrest.

    “Orally, fly agaric mushroom poisoning is associated with suicide attempts, used as a hallucinogen, or accidental ingestion. The effects of fly agaric mushroom peak at 2-3 hours and can last as long as 5 days. Mind-altering effects have occurred with ingestion of 2-4 mushrooms (18).”

    Fly Agaric Mushroom · Natural Medicines adverse-effect record, reported in epilepsy.

    6 sources cited
    1. 30529. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 4-20-1960;31:182-185.
    2. 30530. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric II. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 1961;32:552-555.
    3. 96059. Mikaszewska-Sokolewicz MA, Pankowska S, Janiak M, Pruszczyk P, Lazowski T, Jankowski K. Coma in the course of severe poisoning after consumption of red fly agaric (Amanita muscaria). Acta Biochim Pol. 2016;63(1):181-182. PubMed
    4. 112891. Meisel EM, Morgan B, Schwartz M, Kazzi Z, Cetin H, Sahin A. Two cases of severe Amanita muscaria poisoning including a fatality. Wilderness Environ Med 2022;33(4):412-416.
    5. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    6. 116175. Ebbens EF, Williams SR, Bruccoleri RE, Frazier SB. Neurotoxicity associated with the medicinal mushroom product-Diamond Shruumz: A case report. Toxicol Rep 2024;13:101748. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Drowsiness Additional detail

    Fly Agaric Mushroom

    Recorded for Fly Agaric Mushroom in the same Natural Medicines adverse-effect record shown under Confusion above.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Fly Agaric Mushroom

    “Orally, fly agaric mushroom poisoning is usually associated with suicide attempts or use as a hallucinogen. The effects of fly agaric mushroom peak at 2-3 hours and can last as long as 5 days. The mushrooms can cause auditory and visual hallucinations, delusional thoughts, illusions, and mania, possibly leading to psychomotor agitation and madness (18,30531,30534,96059,116176).”

    Fly Agaric Mushroom · Natural Medicines adverse-effect record, reported in poisoning.

    6 sources cited
    1. 30529. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 4-20-1960;31:182-185.
    2. 30530. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric II. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 1961;32:552-555.
    3. 96059. Mikaszewska-Sokolewicz MA, Pankowska S, Janiak M, Pruszczyk P, Lazowski T, Jankowski K. Coma in the course of severe poisoning after consumption of red fly agaric (Amanita muscaria). Acta Biochim Pol. 2016;63(1):181-182. PubMed
    4. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    5. 30531. ROCH, M. and MACH, J. P. [Severe prolonged delirium caused by Amanita muscaria (fly agaric) poisoning.]. Praxis. 3-3-1960;49:225-227.
    6. 30534. Satora, L., Pach, D., Butryn, B., Hydzik, P., and Balicka-Slusarczyk, B. Fly agaric (Amanita muscaria) poisoning, case report and review. Toxicon 6-1-2005;45(7):941-943. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Stomach pain / Diarrhea / Vomiting / Nausea Additional detail

    Fly Agaric Mushroom

    “Orally, initial symptoms of fly agaric mushroom toxicity usually include nausea, vomiting, diarrhea, and abdominal pain. These often occur within 15-90 minutes of ingestion (18,96059,106533,112891,116175).”

    Fly Agaric Mushroom · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
    2. 96059. Mikaszewska-Sokolewicz MA, Pankowska S, Janiak M, Pruszczyk P, Lazowski T, Jankowski K. Coma in the course of severe poisoning after consumption of red fly agaric (Amanita muscaria). Acta Biochim Pol. 2016;63(1):181-182. PubMed
    3. 106533. Rampolli FI, Kamler P, Carnevale Carlino C, Bedussi F. The Deceptive Mushroom: Accidental Amanita muscaria Poisoning. Eur J Case Rep Intern Med 2021;8(3):002212. PubMed
    4. 112891. Meisel EM, Morgan B, Schwartz M, Kazzi Z, Cetin H, Sahin A. Two cases of severe Amanita muscaria poisoning including a fatality. Wilderness Environ Med 2022;33(4):412-416.
    5. 116175. Ebbens EF, Williams SR, Bruccoleri RE, Frazier SB. Neurotoxicity associated with the medicinal mushroom product-Diamond Shruumz: A case report. Toxicol Rep 2024;13:101748. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

Reported for Fly Agaric Mushroom but not commonly for Cefaclor: hallucinations, seizures and mania or an unusually elevated mood.

Effects for Cefaclor come from the ADVERSE REACTIONS section of its FDA label; effects for Fly Agaric Mushroom come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Fly Agaric Mushroom in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally due to its toxicity; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Cefaclor Products Have a Food Rule — Fly Agaric Mushroom Should Not Break It

At least one FDA label for a product containing Cefaclor says to take it with food. If you take Fly Agaric Mushroom on an empty stomach out of habit, keep them separate — and take Cefaclor with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cefaclor products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The absorption of cefaclor extended-release tablets is enhanced when it is administered with food.

From the Dosage and Administration section of the FDA label we read for Cefaclor — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cefaclor

This page covers Fly Agaric Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefaclor page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefaclor page

“The entries worth understanding before any others on this cefaclor (Ceclor) page are the kidney risks and charcoal. Cefaclor is a cephalosporin antibiotic, typically a short course for ear, sinus, throat, or skin infections, and two herbs here, Siberian cocklebur and asarabacca, can damage the kidneys on their own, so pairing either wi…”

Reviewed by 2 · Jul 18, 2026

Open the Cefaclor interaction page

How much people look this up

Where Fly Agaric Mushroom and Cefaclor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fly Agaric Mushroom
Steady interest

#1,342 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefaclor
Top 10%

#224 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fly Agaric Mushroom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Fly Agaric Mushroom and Cefaclor records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fly Agaric Mushroom

What is Fly Agaric Mushroom?

  • Relaxation and sleep
  • Pain relief (traditional use)
  • Mood and anxiety
  • Ritual and traditional/folk practices
  • Insect control (historical use as a flykiller)

Fly agaric is a poisonous, psychoactive mushroom that contains nerve-acting toxins, and it is not a proven or safe dietary supplement. Eating it raw or in unprocessed form can cause serious poisoning, and there is no reliable evidence it treats any medical condition. We strongly recommend avoiding it and talking to a doctor or pharmacist about safer options.

Amanita muscaria · Amanitaceae · Cap and fruiting body of the mushroom · Dried caps, powders, capsules, tinctures, teas (sold by some vendors as a 'microdose' product)

An interaction check asks whether these two react with each other — it does not ask whether Fly Agaric Mushroom is a good idea for someone in your situation. Here is what our Fly Agaric Mushroom record says about it on its own.

Fly Agaric Mushroom: dosing

There is no established safe or standardized dose for fly agaric. Because the amount of toxins varies greatly between mushrooms—and because preparation methods are inconsistent—any amount carries a real risk of poisoning.We do not recommend using this mushroom. Products sold online that claim a "safe microdose" are not regulated and have not been proven safe.

From our Fly Agaric Mushroom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fly Agaric Mushroom monograph & all interactions
Medication

About Cefaclor

What Is Cefaclor Used For?

Brand names: Ceclor CD, Ceclor

Cefaclor treats a range of bacterial infections. The capsule and oral suspension forms are used for ear infections (otitis media), lower respiratory tract infections including pneumonia, strep throat and tonsillitis, urinary tract infections (including kidney infections and bladder infections), and skin and skin structure infections.

The extended-release tablet form of Cefaclor is approved for a narrower set of uses: acute bacterial flare-ups of chronic bronchitis, strep throat and tonsillitis, and uncomplicated skin infections. Not all infections approved for the capsule or suspension are approved for the extended-release tablet — your prescriber will choose the right form for your infection.

Most-Reported Side Effects for Cefaclor

From FAERS, the FDA’s public side-effect reporting system (1,535 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug hypersensitivity 252 reports
Nausea 159 reports
Vomiting 159 reports
Fatigue 137 reports
Fever 121 reports
See full Cefaclor drug information
Keep checking

Other Drugs & Fly Agaric Mushroom

Browse every other medication we’ve checked against Fly Agaric Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Fly Agaric Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Fly Agaric Mushroom list.

See the full Fly Agaric Mushroom interactions page
See every supplement checked against Cefaclor, ranked by severity
Evidence & sources

Fly Agaric Mushroom References

The 10 references that drive our Fly Agaric Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 4-20-1960;31:182-185.
  3. DONALIES, G. and VOELZ, G. [A suicide attempt with fly agaric II. On the toxicology of Amanita muscaria. With a contribution to the psychology of the choice of suicide agent.]. Nervenarzt 1961;32:552-555.
  4. ROCH, M. and MACH, J. P. [Severe prolonged delirium caused by Amanita muscaria (fly agaric) poisoning.]. Praxis. 3-3-1960;49:225-227.
  5. Satora, L., Pach, D., Butryn, B., Hydzik, P., and Balicka-Slusarczyk, B. Fly agaric (Amanita muscaria) poisoning, case report and review. Toxicon 6-1-2005;45(7):941-943. PubMed
  6. Mikaszewska-Sokolewicz MA, Pankowska S, Janiak M, Pruszczyk P, Lazowski T, Jankowski K. Coma in the course of severe poisoning after consumption of red fly agaric (Amanita muscaria). Acta Biochim Pol. 2016;63(1):181-182. PubMed
  7. Rampolli FI, Kamler P, Carnevale Carlino C, Bedussi F. The Deceptive Mushroom: Accidental Amanita muscaria Poisoning. Eur J Case Rep Intern Med 2021;8(3):002212. PubMed
  8. Meisel EM, Morgan B, Schwartz M, Kazzi Z, Cetin H, Sahin A. Two cases of severe Amanita muscaria poisoning including a fatality. Wilderness Environ Med 2022;33(4):412-416.
  9. Ebbens EF, Williams SR, Bruccoleri RE, Frazier SB. Neurotoxicity associated with the medicinal mushroom product-Diamond Shruumz: A case report. Toxicol Rep 2024;13:101748. PubMed
  10. Maung AC, Hennessey M, Kadiyala R. Accidental colourful mushroom poisoning - delirium, delusions and dreams. Clin Med (Lond) 2023;23(4):417-419. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fly Agaric Mushroom and Cefaclor Together: Common Questions

Is it safe to take Fly Agaric Mushroom with Cefaclor?
We do not list a known interaction between Fly Agaric Mushroom and Cefaclor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Fly Agaric Mushroom and Cefaclor have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Fly Agaric Mushroom and Cefaclor at the same time of day?
At least one FDA label for a product containing Cefaclor says to take it with food. If you take Fly Agaric Mushroom on an empty stomach out of habit, keep them separate and take Cefaclor with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cefaclor products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Cefaclor interact with any supplements?
Yes. Cefaclor has documented interactions with 60 supplements in our database — Fly Agaric Mushroom is not one of them. The Cefaclor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fly Agaric Mushroom monograph Uses, safety profile, and every drug interaction in one place Cefaclor drug information The full plain-English guide to this medication Cefaclor supplement interactions Every supplement checked against Cefaclor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cefaclor and Fly Agaric Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.