Frankincense + Lidocaine
Lidocaine brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, and others.
We found no known interaction between Frankincense and Lidocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Frankincense and Lidocaine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Lidocaine and Frankincense in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Frankincense at all — not against Lidocaine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Frankincense safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Lidocaine
This page covers Frankincense only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lidocaine page lists 145 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Fever Bark (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).
By severity: 3 major · 111 moderate · 31 minor.
From our pharmacist’s overview on the Lidocaine page
“Lidocaine (Xylocaine) deserves genuine care on this page, and I would learn its three major-rated entries first. Grapefruit and St.”
Reviewed by 2 · Jul 18, 2026
Taking Frankincense as Part of a Dietary Supplement Product? Check It for Interactions
We hold 56 real supplement products containing Frankincense, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Frankincense. Even though Frankincense itself has no known interaction with Lidocaine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Frankincense and Lidocaine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#498 of 1,452 supplements looked up here in the last 7 days
#430 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Frankincense reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Frankincense and Lidocaine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Frankincense
What is Frankincense?
- Joint pain and osteoarthritis
- Inflammation
- Digestive complaints
- Asthma and breathing problems
- Calming aromatherapy
Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. Early research is promising for conditions like osteoarthritis, but the evidence is still limited and dosing is not standardized. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Boswellia serrata · Burseraceae · Oleo-gum-resin from the tree bark; essential oil distilled from the resin · Capsules and tablets (often standardized Boswellia extract), resin, essential oil for aromatherapy, topical creams
An interaction check asks whether these two react with each other — it does not ask whether Frankincense is a good idea for someone in your situation. Here is what our Frankincense record says about it on its own.
Frankincense: dosing
There is no official, standardized dose of frankincense. Studies have used different Boswellia extracts standardized to varying amounts of boswellic acids, so it is hard to compare products directly.The safest approach is to follow the directions on the product label and choose a reputable brand that lists its boswellic acid content. Essential oils are for inhalation or diluted topical use only and should never be taken by mouth.
From our Frankincense monograph — the full record covers uses, side effects and every documented interaction.
About Lidocaine Transdermal Patch
What Is Lidocaine Transdermal Patch Used For?
Brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, Lidoject-2, Duo-Trach Kit, Octocaine, Lidoderm, Ztlido
Lidocaine skin patches are applied directly to the painful area to treat post-herpetic neuralgia (PHN) — the persistent burning or aching nerve pain that can remain after a shingles outbreak.
Lidoderm (lidocaine patch 5%) and ZTlido (lidocaine topical system 1.8%) are both indicated for this use in adults. Note that despite their different strengths, one ZTlido topical system provides equivalent lidocaine exposure to one Lidoderm patch.
Most-Reported Side Effects for Lidocaine
From FAERS, the FDA’s public side-effect reporting system (96,036 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Frankincense
Browse every other medication we’ve checked against Frankincense — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Frankincense against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Isotretinoin ›
- Lisinopril ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Frankincense list.
Frankincense References
The 2 references that drive our Frankincense monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Acebo, E., Raton, J. A., Sautua, S., Eizaguirre, X., Trebol, I., and Perez, J. L. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream. Contact Dermatitis 2004;51(2):91-92.
- Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil. Contact Dermatitis 2021;85(4):465-467.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Frankincense and Lidocaine Together: Common Questions
Is it safe to take Frankincense with Lidocaine?
Do Frankincense and Lidocaine have any of the same side effects?
Does Lidocaine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.