Drug & supplement interaction

Gentian + Etravirine

Etravirine brand name: Intelence.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Gentian and Etravirine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Gentian and Etravirine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Etravirine and Gentian in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gentian safety at a glance

Gentian overall Use caution Generally tolerated in small amounts by healthy adults, but it can upset the stomach and is not well studied at high doses.
Pregnancy Avoid Not enough safety data, and traditional cautions exist, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough reliable safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Etravirine and Gentian? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Etravirine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Etravirine is filed under 9 classifications — including non-nucleoside reverse transcriptase inhibitors (nnrtis), cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. Gentian has documented interactions with 1 drug class — the most serious being antihypertensive drugs (moderate) — and none of Etravirine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Gentian Does Interact With Other Medications

Gentian has 172 moderate known drug interactions in our database — Etravirine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Etravirine)
Taking anything else?

Check Another of Your Medications Against Gentian

Covers the 2,830 medications we’ve checked against Gentian. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Gentian and Etravirine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas / Reduced appetite / Diarrhea / Vomiting Additional detail

    Gentian

    “Orally, gentian root, in combination with other herbs, has been reported to cause gastrointestinal adverse effects. Gastrointestinal intolerance occurred in patients with cancer-associated anorexia who took gentian tincture 1 mL three times daily, in conjunction with turmeric 1 gram and ginger 1 gram twice daily, for 14 days.”

    Gentian · Natural Medicines adverse-effect record, reported in anorexia.

    3 sources cited
    1. 374. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
    2. 379. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
    3. 96263. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

    Etravirine

    Listed in the ADVERSE REACTIONS section of the FDA label for Etravirine. Read the label on DailyMed ›

Reported for Gentian but not commonly for Etravirine: nausea.

Effects for Etravirine come from the ADVERSE REACTIONS section of its FDA label; effects for Gentian come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 4,422 voluntary FDA FAERS reports for Etravirine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Etravirine Is Prescribed For, and What Gentian Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Etravirine is a prescription medicine with approved uses on its FDA label. Gentian is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Etravirine is prescribed for: Etravirine (brand name Intelence) is used to treat HIV-1 infection in people who have already received other antiretroviral (HIV) treatments — meaning it is meant for patients whose HIV has had a chance to develop resistance to earlier therapies. It is always used as part of a combination regimen with other HIV medications, never on its own. Both the brand Intelence and generic etravirine tablets are approved for adults and for children ages 2 to under 18 who weigh at least 10 kg (about 22 pounds) and who have already been treated with other HIV drugs.

Gentian has been studied for:

  • Cancer studied, not established Gentian has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Gentian for cancer

    Although there has been interest in using topical gentian for cancer, there is insufficient reliable information about the clinical effects of gentian for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Etravirine on your own; if you are taking Gentian for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Etravirine

This page covers Gentian only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Etravirine page lists 169 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 127 moderate · 39 minor.

From our pharmacist’s overview on the Etravirine page

“For someone taking etravirine (Intelence), an HIV medicine often used when the virus has already resisted other drugs, keeping a steady blood level is the whole point, and this list of 169 supplements and herbs deserves genuine care. The three major-rated entries come first: St.”

Reviewed by 2 · Jul 18, 2026

Open the Etravirine interaction page

One more smart check

Taking Gentian as Part of a Dietary Supplement Product? Check It for Interactions

We hold 749 real supplement products containing Gentian, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gentian. Even though Gentian itself has no known interaction with Etravirine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gentian and Etravirine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gentian
Top 25%

#238 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Etravirine
Steady interest

#2,066 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gentian reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Gentian and Etravirine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gentian

What is Gentian?

  • Loss of appetite
  • Indigestion and bloating
  • Digestive bitter tonic
  • Stomach upset
  • Sluggish digestion

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and preliminary, and while short-term use of normal amounts appears generally well tolerated in healthy adults, anyone with ulcers, reflux, or who is pregnant should be cautious and check with a pharmacist or doctor first.

Gentiana lutea · Gentianaceae · Root and rhizome · Tinctures, liquid extracts, teas, bitters, capsules, dried root

An interaction check asks whether these two react with each other — it does not ask whether Gentian is a good idea for someone in your situation. Here is what our Gentian record says about it on its own.

Gentian: dosing

There is no official, standardized dose for gentian, and products vary widely in strength. Traditional use involves small amounts of a tincture, extract, or tea taken shortly before meals.Because formulations differ, the safest approach is to follow the directions on the product label and not exceed the suggested amount. A pharmacist can help you choose a reasonable product and dose, and can review it against your other medicines and health conditions.

From our Gentian monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gentian monograph & all interactions
Medication

About Etravirine

What Is Etravirine Used For?

Brand name: Intelence

Etravirine (brand name Intelence) is used to treat HIV-1 infection in people who have already received other antiretroviral (HIV) treatments — meaning it is meant for patients whose HIV has had a chance to develop resistance to earlier therapies. It is always used as part of a combination regimen with other HIV medications, never on its own.

Both the brand Intelence and generic etravirine tablets are approved for adults and for children ages 2 to under 18 who weigh at least 10 kg (about 22 pounds) and who have already been treated with other HIV drugs.

Most-Reported Side Effects for Etravirine

From FAERS, the FDA’s public side-effect reporting system (4,422 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug resistance 266 reports
Anxiety 247 reports
Emotional distress 243 reports
Virologic failure 237 reports
Anhedonia 219 reports
See full Etravirine drug information
Keep checking

Other Drugs & Gentian

Browse every other medication we’ve checked against Gentian — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Gentian page.

No interaction 2,657 drugs checked — show the list

We also checked Gentian against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Gentian list.

See the full Gentian interactions page
See every supplement checked against Etravirine, ranked by severity
Evidence & sources

Gentian References

The 5 references that drive our Gentian monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gentian and Etravirine Together: Common Questions

Is it safe to take Gentian with Etravirine?
We do not list a known interaction between Gentian and Etravirine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Gentian and Etravirine have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Gentian and Etravirine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Gentian in each. That is a conversation for your prescriber, especially if Etravirine is being adjusted to a target.
How was the Gentian and Etravirine combination checked?
Interactions in our licensed database are recorded against drug classes. Etravirine is filed under 9 classifications, and Gentian has documented interactions with 1 drug class — none of Etravirine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Gentian interact with any other medications?
Yes. Gentian has 172 documented drug interactions in our database — Etravirine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Etravirine interact with any supplements?
Yes. Etravirine has documented interactions with 169 supplements in our database — Gentian is not one of them. The Etravirine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gentian monograph Uses, safety profile, and every drug interaction in one place Etravirine drug information The full plain-English guide to this medication Etravirine supplement interactions Every supplement checked against Etravirine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Etravirine and Gentian?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.