Drug & supplement interaction

Ground Pine + Oxaprozin

Oxaprozin brand name: Daypro.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ground Pine and Oxaprozin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ground Pine and Oxaprozin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oxaprozin and Ground Pine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ground Pine at all — not against Oxaprozin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ground Pine safety at a glance

Ground Pine overall Use caution Little modern safety data exists, so use cautiously and only under guidance.
Pregnancy Avoid Traditionally linked to menstrual stimulation, so avoid during pregnancy.
Breastfeeding Avoid No safety data in breastfeeding, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oxaprozin and Ground Pine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Oxaprozin’s Own FDA Label Lists

This is not an interaction — none of it involves Ground Pine. These are the most notable effects listed in the ADVERSE REACTIONS section of Oxaprozin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on mentioned in 21.2% of FDA reports for Oxaprozin
  • Pain or burning when passing urine Worth acting on
  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • A heart attack Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on
  • High blood sugar Worth acting on

Showing the 10 most notable of 58 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Oxaprozin. Read the label on DailyMed › Where a percentage is shown, it is the share of 883 voluntary FDA FAERS reports for Oxaprozin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Ground Pine’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Ground Pine side to compare — that is a limit of the record, not a statement that Ground Pine has no side effects.

From our Q&A

Questions About Ground Pine or Oxaprozin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ground Pine or Oxaprozin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Oxaprozin

This page covers Ground Pine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxaprozin page lists 52 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 35 moderate · 12 minor.

From our pharmacist’s overview on the Oxaprozin page

“I would put oxaprozin (Daypro), a long-acting NSAID prescribed for arthritis pain, in the read-carefully category. The interactions that concern me most pile onto the drug's own weak spots: alcohol, meaning the beer and wine entries below, raises the odds of stomach bleeding on any NSAID, and several kidney-stressing herbs can deepen t…”

Reviewed by 2 · Jul 18, 2026

Open the Oxaprozin interaction page

How much people look this up

Where Ground Pine and Oxaprozin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ground Pine
Top half

#697 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oxaprozin
Steady interest

#2,575 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Ground Pine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ground Pine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ground Pine and Oxaprozin records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ground Pine

What is Ground Pine?

  • Joint pain and gout
  • Mild fever
  • Menstrual complaints
  • Wound and skin care
  • Digestive upset

Ground Pine (Ajuga chamaepitys) is a traditional European herb used mainly for joint pain, gout, and menstrual problems, but there is very little modern scientific evidence to support these uses. Because its safety has not been well studied, it should be used cautiously, and it should be avoided in pregnancy and breastfeeding. Talk to a pharmacist or doctor before trying it.

Ajuga chamaepitys · Lamiaceae · Aerial parts (flowering tops, leaves, and stems) · Dried herb, tea/infusion, tincture, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Ground Pine is a good idea for someone in your situation. Here is what our Ground Pine record says about it on its own.

Ground Pine: dosing

There is no established, standardized dose for Ground Pine. It has not been studied enough in modern research to define a safe and effective amount.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Ground Pine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ground Pine monograph & all interactions
Medication

About Oxaprozin

What Is Oxaprozin Used For?

Brand name: Daypro

Oxaprozin treats the signs and symptoms of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis — reducing joint pain, swelling, and stiffness. These uses are shared across available oral formulations, including Coxanto capsules, Oxaprozin capsules, and Oxaprozin tablets (including Daypro).

Juvenile rheumatoid arthritis dosing for children ages 6 to 16 is weight-based and has been studied with both the capsule and tablet formulations.

Most-Reported Side Effects for Oxaprozin

From FAERS, the FDA’s public side-effect reporting system (883 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Chronic kidney disease 82 reports
Drug hypersensitivity 61 reports
Nausea 60 reports
Renal failure 54 reports
Acute kidney injury 51 reports
See full Oxaprozin drug information
Keep checking

Other Drugs & Ground Pine

Browse every other medication we’ve checked against Ground Pine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ground Pine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ground Pine list.

See the full Ground Pine interactions page
See every supplement checked against Oxaprozin, ranked by severity
Evidence & sources

Ground Pine References

The 2 sources that drive our Ground Pine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Ground Pine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
  2. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ground Pine and Oxaprozin Together: Common Questions

Is it safe to take Ground Pine with Oxaprozin?
We do not list a known interaction between Ground Pine and Oxaprozin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Oxaprozin interact with any supplements?
Yes. Oxaprozin has documented interactions with 52 supplements in our database — Ground Pine is not one of them. The Oxaprozin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ground Pine monograph Uses, safety profile, and every drug interaction in one place Oxaprozin drug information The full plain-English guide to this medication Oxaprozin supplement interactions Every supplement checked against Oxaprozin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oxaprozin and Ground Pine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.