Drug & supplement interaction

Haronga + Saxagliptin, metformin XR

Saxagliptin, metformin XR brand name: Kombiglyze.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Haronga and Saxagliptin, metformin XR in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Haronga and Saxagliptin, metformin XR

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Saxagliptin, metformin XR and Haronga in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Haronga at all — not against Saxagliptin, metformin XR, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Haronga safety at a glance

Haronga overall Use caution Limited safety data exist, so use carefully and only when advised.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Saxagliptin, metformin XR and Haronga? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Saxagliptin, metformin XR’s Own FDA Label Lists

This is not an interaction — none of it involves Haronga. These are the most notable effects listed in the ADVERSE REACTIONS section of Saxagliptin, metformin XR’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Bone thinning Worth acting on
  • Severe muscle breakdown Worth acting on
  • Low blood sugar Worth acting on
  • Pancreatitis Worth acting on
  • Heart failure Worth acting on
  • High blood sugar Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • A severe allergic reaction Worth acting on
  • Hives Worth acting on

Showing the 10 most notable of 22 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Saxagliptin, metformin XR. Read the label on DailyMed › Haronga’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Haronga side to compare — that is a limit of the record, not a statement that Haronga has no side effects.

Everything else you take

See Every Supplement That Interacts With Saxagliptin, metformin XR

This page covers Haronga only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Saxagliptin, metformin XR page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Saxagliptin, metformin XR page

“For Kombiglyze (saxagliptin with metformin XR), this list deserves careful reading, not a skim. Most of the 257 supplements on file lower blood sugar on their own, and stacked on a diabetes drug that extra push can tip into hypoglycemia.”

Reviewed by 2 · Jul 18, 2026

Open the Saxagliptin, metformin XR interaction page

How much people look this up

Where Haronga and Saxagliptin, metformin XR Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Haronga
Steady interest

#1,049 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Saxagliptin, metformin XR
Steady interest

#1,963 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Haronga is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Haronga reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Haronga and Saxagliptin, metformin XR records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Haronga

What is Haronga?

  • Indigestion and dyspepsia
  • Loss of appetite
  • Digestive complaints
  • Diarrhea (traditional use)
  • Wound healing (traditional, topical)

Haronga (Harungana madagascariensis) is an African tree whose bark and leaves have been used traditionally and in some European products for indigestion and digestive complaints. Evidence for its benefits is very limited, and safety information is sparse, so it should be used with caution and under the guidance of a pharmacist or doctor.

Harungana madagascariensis · Hypericaceae · Bark and leaves · Capsules, tablets, dried bark, tea, liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether Haronga is a good idea for someone in your situation. Here is what our Haronga record says about it on its own.

Haronga: dosing

There is no well-established standardized dose for Haronga. Amounts vary between products and traditional preparations.If you use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Haronga monograph — the full record covers uses, side effects and every documented interaction.

Read the full Haronga monograph & all interactions
Keep checking

Other Drugs & Haronga

Browse every other medication we’ve checked against Haronga — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Haronga against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Haronga list.

See the full Haronga interactions page
See every supplement checked against Saxagliptin, metformin XR, ranked by severity
Evidence & sources

Haronga References

The 2 sources that drive our Haronga monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Haronga is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Haronga and Saxagliptin, metformin XR Together: Common Questions

Is it safe to take Haronga with Saxagliptin, metformin XR?
We do not list a known interaction between Haronga and Saxagliptin, metformin XR. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Saxagliptin, metformin XR interact with any supplements?
Yes. Saxagliptin, metformin XR has documented interactions with 257 supplements in our database — Haronga is not one of them. The Saxagliptin, metformin XR interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Haronga monograph Uses, safety profile, and every drug interaction in one place Saxagliptin, metformin XR supplement interactions Every supplement checked against Saxagliptin, metformin XR, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Saxagliptin, metformin XR and Haronga?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.