Medication interaction hub

What Supplements Interact with Saxagliptin, metformin XR?

Saxagliptin, metformin XR brand name: Kombiglyze. Every interaction below applies to the brands too.

257 Interactions 2 Major 217 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Saxagliptin, metformin XR? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Saxagliptin, metformin XR against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

For Kombiglyze (saxagliptin with metformin XR), this list deserves careful reading, not a skim. Most of the 257 supplements on file lower blood sugar on their own, and stacked on a diabetes drug that extra push can tip into hypoglycemia. Two carry a major rating, and Siberian cocklebur is the one to refuse outright. Its seeds have caused severe low blood sugar in people, starting soon after consumption and worsening from there.

The other major, activated charcoal, binds oral medications in the gut so less of the drug reaches your blood. A few bulky fibers can blunt metformin absorption in a similar way, so take them well apart from your dose. Among the 217 moderate entries, most add another glucose-lowering effect, while a smaller group raises blood sugar and works against treatment. The 38 minor entries matter less, but the two majors are worth understanding before anything else on this page.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 217 Minor 38 No known interaction 1,195

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Saxagliptin, metformin XR: Top Interactions at a Glance

The Saxagliptin, metformin XR supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 257 interacting ingredients — plus 1,195 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Saxagliptin, metformin XR Combinations Today

The Saxagliptin, metformin XR + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Alpha-lipoic Acid + Saxagliptin, metformin XRi

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Minor Likelihood Possible Vitamin B12 + Saxagliptin, metformin XRi

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.

Read the full interaction Moderate Likelihood Possible Agaricus Mushroom + Saxagliptin, metformin XRi

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Ginger + Saxagliptin, metformin XRi

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Indian Gooseberry + Saxagliptin, metformin XRi

Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Ba Ji Tian + Saxagliptin, metformin XRi

Animal research shows that taking ba ji tian extracts might increase or decrease blood glucose levels.

Read the full interaction
The complete list

Every Supplement Checked Against Saxagliptin, metformin XR

All 1,452 ingredients in our database, ranked by severity — 257 with a Saxagliptin, metformin XR interaction on file and 1,195 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Saxagliptin, metformin XR?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alpha-lipoic Acid with Saxagliptin, metformin XR?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Full Alpha-lipoic Acid + Saxagliptin, metformin XR answer

Can you take Vitamin B12 with Saxagliptin, metformin XR?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.

Full Vitamin B12 + Saxagliptin, metformin XR answer

Can you take Agaricus Mushroom with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Agaricus Mushroom + Saxagliptin, metformin XR answer

Can you take Ginger with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ginger + Saxagliptin, metformin XR answer

Can you take Indian Gooseberry with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.

Full Indian Gooseberry + Saxagliptin, metformin XR answer

Can you take Guava with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might have additive effects and increase the risk of hypoglycemia.

Full Guava + Saxagliptin, metformin XR answer

Can you take Gum Arabic with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Saxagliptin, metformin XR answer

Can you take Hibiscus Sabdariffa with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Hibiscus sabdariffa with antidiabetes drugs might increase the risk of hypoglycemia.

Full Hibiscus Sabdariffa + Saxagliptin, metformin XR answer

Can you take Hollyhock with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal and in vitro research shows that hollyhock flower extracts might lower blood glucose levels.

Full Hollyhock + Saxagliptin, metformin XR answer

Can you take Holy Basil with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Holy Basil + Saxagliptin, metformin XR answer

Can you take Hoodia with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119...

Full Hoodia + Saxagliptin, metformin XR answer

Can you take Horsetail with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.

Full Horsetail + Saxagliptin, metformin XR answer

Can you take Hydrazine Sulfate with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hydrazine sulfate concomitantly with antidiabetes drugs could increase the risk for hypoglycemia.

Full Hydrazine Sulfate + Saxagliptin, metformin XR answer

Can you take Indian Cassia with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian cassia might have additive effects with antidiabetes drugs.

Full Indian Cassia + Saxagliptin, metformin XR answer

Can you take Indian Long Pepper with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Indian Long Pepper + Saxagliptin, metformin XR answer

Can you take Indian Snakeroot with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Indian snakeroot with antidiabetes drugs might increase the risk of hypoglycemia.

Full Indian Snakeroot + Saxagliptin, metformin XR answer

Can you take Indigo Pulchra with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, indigo pulchra might lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Full Indigo Pulchra + Saxagliptin, metformin XR answer

Can you take Inositol with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Full Inositol + Saxagliptin, metformin XR answer

Can you take Irvingia Gabonensis with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.

Full Irvingia Gabonensis + Saxagliptin, metformin XR answer

Can you take Jackfruit with Saxagliptin, metformin XR?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jackfruit might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Jackfruit + Saxagliptin, metformin XR answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Saxagliptin, metformin XR is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Saxagliptin, metformin XR, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Saxagliptin, metformin XR sits in 4 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Saxagliptin, metformin XR through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Saxagliptin, metformin XR through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Saxagliptin, metformin XR through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Saxagliptin, metformin XR through this category.

Related: does Saxagliptin, metformin XR deplete any nutrients?

Saxagliptin, metformin XR has 4 reported nutrient associations in the research literature — see the Saxagliptin, metformin XR nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Saxagliptin, metformin XR

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Saxagliptin, metformin XR.

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Pharmacist Counseling Corner

Saxagliptin, metformin XR & Supplements: Common Questions

What supplements interact with Saxagliptin, metformin XR?
In our interaction database, 257 supplement and herbal ingredients have an interaction with Saxagliptin, metformin XR on file — 2 rated major, 217 moderate, and 38 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Saxagliptin, metformin XR supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Saxagliptin, metformin XR?
That depends entirely on which supplement. The honest answer for Saxagliptin, metformin XR is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Kombiglyze have the same supplement interactions as Saxagliptin, metformin XR?
Yes — Kombiglyze all contain Saxagliptin, metformin XR, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Saxagliptin, metformin XR deplete any vitamins or nutrients?
It might — Saxagliptin, metformin XR has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Saxagliptin, metformin XR nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Saxagliptin, metformin XR and my other medications?
This page covers Saxagliptin, metformin XR against supplements and herbal ingredients. Checking Saxagliptin, metformin XR against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.