Eyebright - Kombiglyze (Saxagliptin, metformin XR) Interaction
Herbal: Eyebright
Also Known As: Euphrasia rostkoviana, Euphrasia officinalis, Euphrasia stricta, Aufraise, Augentrostkraut, Casse-Lunettes, Eufrasia, Euphraise, Euphraise Officinale, Euphraise de Rostkov, Euphrasia, Euphraisia Eye Bright, Euphrasiae Herba, Eye Bright, Herbe d'Euphraise, Luminet
Drug: Saxagliptin, metformin XR
Brand names:
Kombiglyze
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Saxagliptin, metformin XR is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, eyebright might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that eyebright lowers blood glucose levels.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Porchezhian, E., Ansari, S. H., and Shreedharan, N. K. Antihyperglycemic activity of Euphrasia officinale leaves. Fitoterapia 2000;71(5):522-526.
Eyebright Overview
Euphrasia Officinalis, commonly known as eyebright, is a plant that belongs to the Orobanchaceae family and is native to Europe and Asia.
The aerial parts of the eyebright, including the leaves, stem, and flowers, are used for medicinal purposes. They contain several compounds, including flavonoids, tannins, and iridoid glycosides, which are believed to be responsible for the plant's medicinal properties.
Eyebright has traditionally been used to treat various eye conditions such as conjunctivitis, blepharitis, and eye strain. It also is purported to have anti-inflammatory properties that can help reduce inflammation in the eyes and nasal passages.
Eyebright - More Interactions
Eyebright interacts with 84 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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