Drug & supplement interaction

Hazelnut + Duloxetine

Duloxetine brand names: Cymbalta, Drizalma Sprinkle, Irenka.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hazelnut and Duloxetine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hazelnut and Duloxetine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Duloxetine and Hazelnut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hazelnut at all — not against Duloxetine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hazelnut safety at a glance

Hazelnut overall Use caution Generally safe as a food for most people, but a common cause of serious tree nut allergy.
Pregnancy Likely Safe When used in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When used in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Duloxetine and Hazelnut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Hazelnut Itself Has Been Linked To

This is not an interaction — nothing below involves Duloxetine. It is the side-effect record for Hazelnut on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Hazelnut, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction / An allergic reaction Worth acting on Additional detail

    “Orally, hazelnut is well tolerated.

    Serious Adverse Effects (Rare):

    All routes of administration: Allergic reactions, including oral allergy syndrome and anaphylaxis.”

    Hazelnut · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    “Orally, hazelnut can cause an allergic reaction in sensitive individuals, with severity ranging from oral allergy syndrome to anaphylaxis. The prevalence of hazelnut sensitization varies by geographic location, with hazelnut allergy reported more often in areas with greater birch tree pollen exposure. Hazelnut allergy is more common in adults than children, but children are more likely to develop severe reactions.”

    Hazelnut · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 102032. Valcour A, Lidholm J, Borres MP, Hamilton RG. Sensitization profiles to hazelnut allergens across the United States. Ann Allergy Asthma Immunol 2019;122(1):111-6.e1. PubMed
  • A skin rash Additional detail

    “Orally, hazelnut can cause atopic dermatitis in patients with a hazelnut allergy. In one case, hazelnut essence in hydroxyzine syrup was determined to be the likely cause of atopic dermatitis in a toddler.”

    Hazelnut · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 102031. Peroni DG, Dall'Agnola A, Piacentini GL, Boner AL. Worsening of atopic dermatitis by hazelnut essence contained in hydroxyzine syrup. Acta Paediatr 2007;96(11):1710. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Hazelnut — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Duloxetine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Duloxetine column appears here.

Special populations

Hazelnut in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used in amounts commonly found in foods.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Hazelnut or Duloxetine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hazelnut or Duloxetine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Duloxetine

This page covers Hazelnut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Duloxetine page lists 132 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Lithium (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 107 moderate · 20 minor.

Open the Duloxetine interaction page

One more smart check

Taking Hazelnut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 5 real supplement products containing Hazelnut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hazelnut. Even though Hazelnut itself has no known interaction with Duloxetine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hazelnut and Duloxetine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hazelnut
Steady interest

#769 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Duloxetine
Top 5%

#48 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hazelnut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hazelnut and Duloxetine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hazelnut

What is Hazelnut?

  • Heart and cholesterol health
  • Source of healthy fats and protein
  • Antioxidant support
  • Blood sugar support
  • General nutrition and snacking

Hazelnuts are a nutritious tree nut rich in healthy fats, fiber, vitamin E, and antioxidants, and eating them as part of a balanced diet may support heart health. They are mainly a food rather than a treatment, and the biggest safety concern is that they are a common cause of serious nut allergy.

Corylus avellana · Betulaceae · Nut (kernel), nut oil, and sometimes leaves · Whole nuts, hazelnut oil, hazelnut flour/meal, nut butter, and skin or leaf extracts in some supplements

An interaction check asks whether these two react with each other — it does not ask whether Hazelnut is a good idea for someone in your situation. Here is what our Hazelnut record says about it on its own.

Hazelnut: dosing

There is no official medical dose for hazelnuts. As a food, a small handful (about an ounce) is a common serving size in studies of nuts and heart health.For any hazelnut supplement, oil, or extract, there is no standardized dose.

From our Hazelnut monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hazelnut monograph & all interactions
Medication

About Duloxetine

What Is Duloxetine Used For?

Brand names: Cymbalta, Drizalma Sprinkle, Irenka

Duloxetine delayed-release capsules treat major depressive disorder (MDD) and generalized anxiety disorder (GAD) in adults. They also manage diabetic peripheral neuropathic pain (nerve pain from diabetes), fibromyalgia, and chronic musculoskeletal pain (such as chronic low back pain and pain from osteoarthritis) in adults.

GAD is also approved in pediatric patients 7 years and older for Cymbalta, Drizalma Sprinkle, and certain duloxetine delayed-release capsule products. Fibromyalgia is approved in patients 13 years and older for Cymbalta and some duloxetine delayed-release capsule products. Age-specific approvals vary by product — follow your prescriber's guidance on which product is right for your age group.

See full Duloxetine drug information
Keep checking

Other Drugs & Hazelnut

Browse every other medication we’ve checked against Hazelnut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Hazelnut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hazelnut list.

See the full Hazelnut interactions page
See every supplement checked against Duloxetine, ranked by severity
Evidence & sources

Hazelnut References

The 2 references that drive our Hazelnut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Peroni DG, Dall'Agnola A, Piacentini GL, Boner AL. Worsening of atopic dermatitis by hazelnut essence contained in hydroxyzine syrup. Acta Paediatr 2007;96(11):1710. PubMed
  2. Valcour A, Lidholm J, Borres MP, Hamilton RG. Sensitization profiles to hazelnut allergens across the United States. Ann Allergy Asthma Immunol 2019;122(1):111-6.e1. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hazelnut and Duloxetine Together: Common Questions

Is it safe to take Hazelnut with Duloxetine?
We do not list a known interaction between Hazelnut and Duloxetine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Duloxetine interact with any supplements?
Yes. Duloxetine has documented interactions with 132 supplements in our database — Hazelnut is not one of them. The Duloxetine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hazelnut monograph Uses, safety profile, and every drug interaction in one place Duloxetine drug information The full plain-English guide to this medication Duloxetine supplement interactions Every supplement checked against Duloxetine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Duloxetine and Hazelnut?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.