Drug & supplement interaction

Hercules Club + Magaldrate

Magaldrate brand name: Riopan.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Hercules Club has a minor interaction with Magaldrate. Theoretically, Hercules club may decrease the clinical effects of antacids.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Hercules Club and Magaldrate

Here is the interaction we found between these two, with the evidence behind it.

Minor

ANTACIDS

Why this applies to Magaldrate

Magaldrate falls under ANTACIDS — the group Hercules Club interacts with.

Theoretically, Hercules club may decrease the clinical effects of antacids.
Due to reports that Hercules club increases stomach acid, Hercules club might decrease the effectiveness of antacids.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Magaldrate (Riopan) is a simple antacid. It works right in your stomach by neutralizing acid to ease heartburn, indigestion, and that burning feeling in your chest. It isn't activated by your liver, so this isn't a prodrug situation. The concern here is more about chemistry in the stomach itself.

Here's the idea: there are old reports that Hercules Club may bump up stomach acid production. If that's true, it could work against what Magaldrate is trying to do, meaning your antacid might not calm things down as well. Keep in mind this is theoretical and based only on anecdotal reports, so it's a minor, low-certainty concern. If you take both and notice your heartburn isn't easing up, mention it to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Hercules Club Also Interacts With Other Medications

Hercules Club has 35 minor known drug interactions in our database — the Magaldrate one above is one of them. If you take anything else, check it against the full list below.

Minor 35 No known interaction 2,795 (incl. Magaldrate)
Taking anything else?

Check Another of Your Medications Against Hercules Club

Covers the 2,830 medications we’ve checked against Hercules Club. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Magaldrate

This page covers Hercules Club only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Magaldrate page lists 30 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Cinchona (moderate), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 1 major · 10 moderate · 19 minor.

From our pharmacist’s overview on the Magaldrate page

“Activated charcoal carries the only major rating among the 30 supplements and herbs on file for magaldrate (Riopan), because it adsorbs medicines in the gut and cuts how much the body absorbs. That single entry is why this page deserves real care even though magaldrate is just a heartburn remedy.”

Reviewed by 2 · Jul 18, 2026

Open the Magaldrate interaction page

How much people look this up

Where Hercules Club and Magaldrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hercules Club
Steady interest

#1,109 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Magaldrate
Steady interest

#2,461 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Hercules Club

What is Hercules Club?

Hercules Club
  • Toothache and mouth pain
  • Indigestion and sluggish digestion
  • Rheumatism and joint pain
  • Circulation (as a stimulant or tonic)
  • Sore throat

Hercules Club (southern prickly ash) is a traditional folk remedy used mainly for toothache, digestion, and joint pain, often by chewing the bark, which causes a tingling, numbing feeling in the mouth. Modern scientific evidence supporting these uses is very limited, and safety has not been well studied, so it is best to talk with a pharmacist or doctor before using it.

Read the full Hercules Club monograph & all interactions
Keep checking

Other Drugs & Hercules Club

Browse every other medication we’ve checked against Hercules Club — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
35Minor
2,794No known interaction
35 Minor 2,794 No interaction
Minor

35 interactions

No interaction 2,794 drugs checked — show the list

We also checked Hercules Club against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,794 medications checked with no known interaction — see the full Hercules Club list.

See the full Hercules Club interactions page
See every supplement checked against Magaldrate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Hercules Club monograph › Uses, safety, and every drug interaction in one place Magaldrate supplement interactions › Every supplement checked against Magaldrate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Hercules Club and Magaldrate Together: Common Questions

Can you take Hercules Club with Magaldrate?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Hercules Club and Magaldrate interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.