Drug & supplement interaction

Hercules Club + Memantine

Memantine brand name: Ebixa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hercules Club and Memantine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hercules Club and Memantine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Memantine and Hercules Club in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hercules Club safety at a glance

Hercules Club overall Use caution Limited safety data exist, and the plant is best used only with professional guidance.
Pregnancy Likely Unsafe When used orally because it might have menstrual stimulant effects. There is insufficient reliable information available about the safety of the berry during pr... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally because it might cause colic in nursing infants. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Memantine and Hercules Club? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Memantine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Memantine is filed under 2 classifications — nmda antagonists, oral drugs. Hercules Club has documented interactions with 3 drug classes — the most serious being antacids (minor), h2-blockers (minor) and proton pump inhibitors (ppis) (minor) — and none of Memantine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hercules Club Does Interact With Other Medications

Hercules Club has 36 minor known drug interactions in our database — Memantine isn’t one of them. If you take anything else, check it against the full list below.

Minor 36 No known interaction 2,794 (incl. Memantine)
Taking anything else?

Check Another of Your Medications Against Hercules Club

Covers the 2,830 medications we’ve checked against Hercules Club. Pick one to open its full report.

What to actually watch for

What Memantine’s Own FDA Label Lists

This is not an interaction — none of it involves Hercules Club. These are the most notable effects listed in the ADVERSE REACTIONS section of Memantine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on
  • Heart failure Worth acting on
  • Confusion Worth acting on
  • A severe skin reaction Worth acting on
  • Seizures Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Raised blood pressure Worth acting on

Showing the 10 most notable of 22 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Memantine. Read the label on DailyMed › Hercules Club’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Hercules Club side to compare — that is a limit of the record, not a statement that Hercules Club has no side effects.

Special populations

Hercules Club in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally because it might have menstrual stimulant effects. There is insufficient reliable information available about the safety of the berry during pregnancy; avoid using.

Lactation Possibly Unsafe

When used orally because it might cause colic in nursing infants.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Memantine

This page covers Hercules Club only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Memantine page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Threonine (major), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 2 major · 7 moderate · 9 minor.

Open the Memantine interaction page

How much people look this up

Where Hercules Club and Memantine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hercules Club
Steady interest

#1,401 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Memantine
Steady interest

#1,635 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hercules Club reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hercules Club and Memantine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hercules Club

What is Hercules Club?

Hercules Club
  • Toothache and mouth pain
  • Indigestion and sluggish digestion
  • Rheumatism and joint pain
  • Circulation (as a stimulant or tonic)
  • Sore throat

Hercules Club (southern prickly ash) is a traditional folk remedy used mainly for toothache, digestion, and joint pain, often by chewing the bark, which causes a tingling, numbing feeling in the mouth. Modern scientific evidence supporting these uses is very limited, and safety has not been well studied, so it is best to talk with a pharmacist or doctor before using it.

Zanthoxylum clava-herculis · Rutaceae · Bark, roots, and berries · Dried bark, tinctures, teas, and topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Hercules Club is a good idea for someone in your situation. Here is what our Hercules Club record says about it on its own.

Hercules Club: dosing

There is no established standardized dose for Hercules Club. Traditional use varied widely, and product strengths differ from one brand to another.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Hercules Club monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hercules Club monograph & all interactions
Medication

About Memantine

What Is Memantine Used For?

Brand name: Ebixa

Memantine treats moderate to severe dementia of the Alzheimer's type. It is available as tablets, extended-release capsules, and an oral solution — all approved for this same use.

It does not cure Alzheimer's disease and is not shown to prevent or slow the underlying loss of brain cells. It is used to help manage symptoms of moderate to severe disease.

See full Memantine drug information
Keep checking

Other Drugs & Hercules Club

Browse every other medication we’ve checked against Hercules Club — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
36Minor
2,793No known interaction
36 Minor 2,793 No interaction
Minor

36 interactions

No interaction 2,793 drugs checked — show the list

We also checked Hercules Club against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,793 medications checked with no known interaction — see the full Hercules Club list.

See the full Hercules Club interactions page
See every supplement checked against Memantine, ranked by severity
Evidence & sources

Hercules Club References

The 2 references that drive our Hercules Club monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hercules Club and Memantine Together: Common Questions

Is it safe to take Hercules Club with Memantine?
We do not list a known interaction between Hercules Club and Memantine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Hercules Club and Memantine combination checked?
Interactions in our licensed database are recorded against drug classes. Memantine is filed under 2 classifications, and Hercules Club has documented interactions with 3 drug classes — none of Memantine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hercules Club interact with any other medications?
Yes. Hercules Club has 36 documented drug interactions in our database — Memantine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Memantine interact with any supplements?
Yes. Memantine has documented interactions with 18 supplements in our database — Hercules Club is not one of them. The Memantine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hercules Club monograph Uses, safety profile, and every drug interaction in one place Memantine drug information The full plain-English guide to this medication Memantine supplement interactions Every supplement checked against Memantine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Memantine and Hercules Club?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.