Drug & supplement interaction

Hu Zhang + Teniposide

Teniposide brand name: Vumon.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Hu Zhang has a moderate interaction with Teniposide. Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Hu Zhang and Teniposide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES

Why this applies to Teniposide

Teniposide falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES — the group Hu Zhang interacts with.

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the basic idea with Hu Zhang and your child's teniposide (Vumon). This herb is rich in resveratrol, and in test-tube studies resveratrol can slow down a liver enzyme called CYP2C19. Teniposide is partly broken down by that same enzyme. If it's cleared more slowly, levels in the body could creep up, which in theory means stronger effects and a higher chance of side effects like low blood counts, infections, mouth sores, nausea, or hair loss.

I want to be honest, though: this is only a theoretical concern from lab data, and it has never actually been reported in people. Still, with a chemotherapy drug for leukemia there's no room to guess. Please don't add Hu Zhang without first clearing it with your child's oncology team.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Hu Zhang Also Interacts With Other Medications

Hu Zhang has 825 moderate known drug interactions in our database — the Teniposide one above is one of them. If you take anything else, check it against the full list below.

Moderate 825 No known interaction 2,005 (incl. Teniposide)
Taking anything else?

Check Another of Your Medications Against Hu Zhang

Covers the 2,830 medications we’ve checked against Hu Zhang. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Teniposide

This page covers Hu Zhang only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Teniposide page lists 51 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Artichoke (moderate), Bacopa (moderate) and Baikal Skullcap (moderate).

By severity: 1 major · 37 moderate · 13 minor.

Open the Teniposide interaction page

One more smart check

Taking Hu Zhang as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,014 real supplement products containing Hu Zhang, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hu Zhang. Your product may carry other ingredients that interact with Teniposide too, on top of Hu Zhang — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hu Zhang and Teniposide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hu Zhang
Top 25%

#218 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Teniposide
Steady interest

#1,866 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Hu Zhang

What is Hu Zhang?

  • Source of resveratrol
  • Heart and circulation support
  • Inflammation
  • Liver and digestive complaints (traditional)
  • Cough and respiratory symptoms (traditional)
  • Skin and joint conditions (traditional topical use)

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for inflammation and heart health, but high-quality evidence in people is limited. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Hu Zhang monograph & all interactions
Medication

About Teniposide Injection

What Is Teniposide Injection Used For?

Brand name: Vumon

  • Teniposide is used with other chemotherapy drugs to treat acute lymphocytic leukemia (ALL; a type of cancer of the white blood cells) in children that has not improved or that has worsened after treatment with other medications. Teniposide is in a class of medications known as podophyllotoxin derivatives. It works by slowing or stopping the growth of cancer cells in your body.

See full Teniposide Injection drug information
Keep checking

Other Drugs & Hu Zhang

Browse every other medication we’ve checked against Hu Zhang — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
825Moderate
0Minor
2,004No known interaction
825 Moderate 2,004 No interaction
Moderate

825 interactions

Showing 60 of 825 moderate interactions — see all 825 on the Hu Zhang page.

No interaction 2,004 drugs checked — show the list

We also checked Hu Zhang against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,004 medications checked with no known interaction — see the full Hu Zhang list.

See the full Hu Zhang interactions page
See every supplement checked against Teniposide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Hu Zhang monograph › Uses, safety, and every drug interaction in one place Teniposide supplement interactions › Every supplement checked against Teniposide, ranked by severity Teniposide Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Hu Zhang and Teniposide Together: Common Questions

Can you take Hu Zhang with Teniposide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Hu Zhang and Teniposide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Teniposide and Hu Zhang?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.