Drug & supplement interaction

Ivy Gourd + Afilibercept

Afilibercept brand name: Eylea.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ivy Gourd and Afilibercept in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ivy Gourd and Afilibercept

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Afilibercept and Ivy Gourd in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ivy Gourd safety at a glance

Ivy Gourd overall Use caution Generally considered safe as a food, but supplement doses are less studied and may affect blood sugar.
Pregnancy Avoid There is not enough safety information, so medicinal amounts are best avoided during pregnancy.
Breastfeeding Avoid Safety has not been established, so it is best to avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Afilibercept and Ivy Gourd? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Ivy Gourd Does Interact With Other Medications

Ivy Gourd has 86 moderate known drug interactions in our database — Afilibercept isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Afilibercept)
Taking anything else?

Check Another of Your Medications Against Ivy Gourd

Covers the 2,830 medications we’ve checked against Ivy Gourd. Pick one to open its full report.

What to actually watch for

What Ivy Gourd Itself Has Been Linked To

This is not an interaction — nothing below involves Afilibercept. It is the side-effect record for Ivy Gourd on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ivy Gourd, this list is the first place to look.

  • Drowsiness / Headache Additional detail

    “Orally, ivy gourd leaf seems to be well-tolerated. It may cause mild nausea, headache, and drowsiness.”

    Ivy Gourd · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 17752. Munasinghe MAAK, Abeysena C, Yaddehige IS, et al. Blood sugar lowering effect of Coccinia grandis (L.) J. Voight: path for a new drug for diabetes mellitus. Exp Diabetes Res 2011; doi: 10.1155/2011/978762.

    “Orally, ivy gourd leaf may cause mild headache and drowsiness.”

    Ivy Gourd · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 17752. Munasinghe MAAK, Abeysena C, Yaddehige IS, et al. Blood sugar lowering effect of Coccinia grandis (L.) J. Voight: path for a new drug for diabetes mellitus. Exp Diabetes Res 2011; doi: 10.1155/2011/978762.
  • Nausea Additional detail

    “Orally, ivy gourd leaf may cause mild nausea.”

    Ivy Gourd · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 17752. Munasinghe MAAK, Abeysena C, Yaddehige IS, et al. Blood sugar lowering effect of Coccinia grandis (L.) J. Voight: path for a new drug for diabetes mellitus. Exp Diabetes Res 2011; doi: 10.1155/2011/978762.

Everything above comes from the Natural Medicines adverse-effect record for Ivy Gourd — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Afilibercept’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Afilibercept column appears here.

Overlapping uses

What Afilibercept Is Prescribed For, and What Ivy Gourd Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Afilibercept is a prescription medicine with approved uses on its FDA label. Ivy Gourd is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Afilibercept is prescribed for: Eylea is used to treat several serious eye conditions that involve abnormal blood vessel growth or fluid leakage in the retina. These include neovascular (wet) age-related macular degeneration (AMD), macular edema following retinal vein occlusion (RVO), diabetic macular edema (DME), diabetic retinopathy (DR), and retinopathy of prematurity (ROP) in pre-term infants. All of these uses involve an injection given directly into the eye by a qualified physician. The specific dosing schedule varies by condition, so the regimen your doctor prescribes will be tailored to your diagnosis.

Ivy Gourd has been studied for:

  • Diabetes Natural Medicines rates the evidence for Ivy Gourd: Possibly Effective Read what the research shows

    Ivy Gourd for diabetes

    Preliminary clinical research shows that taking ivy gourd leaves 20 grams with breakfast significantly improves glucose control after receiving a meal containing 75 grams of glucose. Other preliminary clinical research shows that taking ivy gourd orally twice daily for 6 weeks improves glucose tolerance compared to baseline in patients with diabetes.

    4 sources cited
    1. 17752. Munasinghe MAAK, Abeysena C, Yaddehige IS, et al. Blood sugar lowering effect of Coccinia grandis (L.) J. Voight: path for a new drug for diabetes mellitus. Exp Diabetes Res 2011; doi: 10.1155/2011/978762.
    2. 12693. Khan AK, AKhtar S, Mahtab H. Treatment of diabetes mellitus with Coccinia indica. Br Med J 1980;280:1044. PubMed
    3. 56889. Kuriyan, R., Rajendran, R., Bantwal, G., and Kurpad, A. V. Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diabetes Care 2008;31(2):216-220.
    4. 110430. Wasana KGP, Attanayake AP, Weerarathna TP, Jayatilaka KAPW. Efficacy and safety of a herbal drug of Coccinia grandis (Linn.) Voigt in patients with type 2 diabetes mellitus: A double blind randomized placebo controlled clinical trial. Phytomedicine. 2021 PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Afilibercept on your own; if you are taking Ivy Gourd for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

One more smart check

Taking Ivy Gourd as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Ivy Gourd, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ivy Gourd. Even though Ivy Gourd itself has no known interaction with Afilibercept, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ivy Gourd and Afilibercept Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ivy Gourd
Top half

#553 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Afilibercept
Top half

#1,353 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ivy Gourd reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ivy Gourd and Afilibercept records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ivy Gourd

What is Ivy Gourd?

  • Blood sugar support
  • Digestive complaints
  • Skin conditions
  • General wellness and nutrition

Ivy gourd is a tropical vine widely eaten as a vegetable and used in traditional medicine, most often for blood sugar support. Early human research hints it may modestly lower blood sugar, but the evidence is limited and not strong enough to replace standard diabetes care. If you have diabetes or take medicine, talk to your pharmacist or doctor before using ivy gourd supplements.

Coccinia grandis · Cucurbitaceae · Fruit, leaves, stems, and roots · Fresh vegetable, dried powder, capsules, leaf extracts, teas

An interaction check asks whether these two react with each other — it does not ask whether Ivy Gourd is a good idea for someone in your situation. Here is what our Ivy Gourd record says about it on its own.

Ivy Gourd: dosing

There is no official or well-established standard dose for ivy gourd supplements. Studies have used different forms and amounts, so it is hard to recommend a specific dose.If you choose to use an ivy gourd product, follow the directions on the product label and do not exceed the recommended amount.

From our Ivy Gourd monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ivy Gourd monograph & all interactions
Medication

About Aflibercept Injection

What Is Aflibercept Injection Used For?

Brand name: Eylea

Eylea is used to treat several serious eye conditions that involve abnormal blood vessel growth or fluid leakage in the retina. These include neovascular (wet) age-related macular degeneration (AMD), macular edema following retinal vein occlusion (RVO), diabetic macular edema (DME), diabetic retinopathy (DR), and retinopathy of prematurity (ROP) in pre-term infants.

All of these uses involve an injection given directly into the eye by a qualified physician. The specific dosing schedule varies by condition, so the regimen your doctor prescribes will be tailored to your diagnosis.

See full Aflibercept Injection drug information
Keep checking

Other Drugs & Ivy Gourd

Browse every other medication we’ve checked against Ivy Gourd — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Ivy Gourd page.

No interaction 2,743 drugs checked — show the list

We also checked Ivy Gourd against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Ivy Gourd list.

See the full Ivy Gourd interactions page
See every supplement checked against Afilibercept, ranked by severity
Evidence & sources

Ivy Gourd References

The 5 references that drive our Ivy Gourd monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Khan AK, AKhtar S, Mahtab H. Treatment of diabetes mellitus with Coccinia indica. Br Med J 1980;280:1044. PubMed
  2. Munasinghe MAAK, Abeysena C, Yaddehige IS, et al. Blood sugar lowering effect of Coccinia grandis (L.) J. Voight: path for a new drug for diabetes mellitus. Exp Diabetes Res 2011; doi: 10.1155/2011/978762.
  3. Venkateswaran, S. and Pari, L. Effect of Coccinia indica leaf extract on plasma antioxidants in streptozotocin- induced experimental diabetes in rats. Phytother.Res 2003;17(6):605-608.
  4. Kuriyan, R., Rajendran, R., Bantwal, G., and Kurpad, A. V. Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diabetes Care 2008;31(2):216-220.
  5. Wasana KGP, Attanayake AP, Weerarathna TP, Jayatilaka KAPW. Efficacy and safety of a herbal drug of Coccinia grandis (Linn.) Voigt in patients with type 2 diabetes mellitus: A double blind randomized placebo controlled clinical trial. Phytomedicine. 2021 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ivy Gourd and Afilibercept Together: Common Questions

Is it safe to take Ivy Gourd with Afilibercept?
We do not list a known interaction between Ivy Gourd and Afilibercept. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Ivy Gourd and Afilibercept used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Ivy Gourd in each. That is a conversation for your prescriber, especially if Afilibercept is being adjusted to a target.
Does Ivy Gourd interact with any other medications?
Yes. Ivy Gourd has 86 documented drug interactions in our database — Afilibercept is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ivy Gourd monograph Uses, safety profile, and every drug interaction in one place Aflibercept Injection drug information The full plain-English guide to this medication Afilibercept supplement interactions Every supplement checked against Afilibercept, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Afilibercept and Ivy Gourd?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.