Drug & supplement interaction

Ivy Gourd + Saxagliptin

Saxagliptin brand name: Onglyza.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Ivy Gourd has a moderate interaction with Saxagliptin. Ivy gourd may lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceA
What do Severity, Likelihood & Evidence mean?
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Interaction report

Ivy Gourd and Saxagliptin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Saxagliptin

Saxagliptin falls under ANTIDIABETES DRUGS — the group Ivy Gourd interacts with.

Ivy gourd may lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
Severity Moderate Likelihood Probable Evidence A

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: ivy gourd, when taken as a concentrated supplement, may gently lower your blood sugar on its own. Saxagliptin (Onglyza) already nudges your body to make more insulin after meals. Put the two together and their blood-sugar-lowering effects can stack up, which can push your numbers too low.

This isn't a worry about saxagliptin building up in your body. It's about an additive effect. Watch for signs of low blood sugar like shakiness, sweating, dizziness, a racing heart, or sudden hunger, especially if you skip meals. The good news is this is manageable. If you'd like to try ivy gourd, check with your pharmacist or doctor first so they can help you monitor your readings. Eating ivy gourd as a normal vegetable is far less likely to matter than a concentrated supplement.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Khan AK, AKhtar S, Mahtab H. Treatment of diabetes mellitus with Coccinia indica. Br Med J 1980;280:1044. PubMed
  2. Venkateswaran, S. and Pari, L. Effect of Coccinia indica leaf extract on plasma antioxidants in streptozotocin- induced experimental diabetes in rats. Phytother.Res 2003;17(6):605-608.
  3. Kuriyan, R., Rajendran, R., Bantwal, G., and Kurpad, A. V. Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diabetes Care 2008;31(2):216-220.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Ivy Gourd Also Interacts With Other Medications

Ivy Gourd has 85 moderate known drug interactions in our database — the Saxagliptin one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Saxagliptin)
Taking anything else?

Check Another of Your Medications Against Ivy Gourd

Covers the 2,830 medications we’ve checked against Ivy Gourd. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Saxagliptin

This page covers Ivy Gourd only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Saxagliptin page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Saxagliptin page

“Siberian cocklebur is the one supplement anyone on saxagliptin (Onglyza) for type 2 diabetes should avoid outright. Its seeds have caused severe hypoglycemia in people, dropping blood sugar soon after consumption and often worsening from there.”

Reviewed by 2 · Jul 18, 2026

Open the Saxagliptin interaction page

One more smart check

Taking Ivy Gourd as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Ivy Gourd, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ivy Gourd. Your product may carry other ingredients that interact with Saxagliptin too, on top of Ivy Gourd — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ivy Gourd and Saxagliptin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ivy Gourd
Top half

#537 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Saxagliptin
Steady interest

#2,383 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Ivy Gourd

What is Ivy Gourd?

  • Blood sugar support
  • Digestive complaints
  • Skin conditions
  • General wellness and nutrition

Ivy gourd is a tropical vine widely eaten as a vegetable and used in traditional medicine, most often for blood sugar support. Early human research hints it may modestly lower blood sugar, but the evidence is limited and not strong enough to replace standard diabetes care. If you have diabetes or take medicine, talk to your pharmacist or doctor before using ivy gourd supplements.

Read the full Ivy Gourd monograph & all interactions
Medication

About Saxagliptin

What Is Saxagliptin Used For?

Brand name: Onglyza

Saxagliptin tablets are used to help adults with type 2 diabetes control their blood sugar levels. It is meant to be used together with diet and exercise, either alone or alongside other diabetes medicines.

Saxagliptin tablets are not for type 1 diabetes or diabetic ketoacidosis (a dangerous complication where the blood becomes too acidic).

See full Saxagliptin drug information
Keep checking

Other Drugs & Ivy Gourd

Browse every other medication we’ve checked against Ivy Gourd — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Ivy Gourd page.

No interaction 2,744 drugs checked — show the list

We also checked Ivy Gourd against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Ivy Gourd list.

See the full Ivy Gourd interactions page
See every supplement checked against Saxagliptin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Ivy Gourd monograph › Uses, safety, and every drug interaction in one place Saxagliptin supplement interactions › Every supplement checked against Saxagliptin, ranked by severity Saxagliptin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Ivy Gourd and Saxagliptin Together: Common Questions

Can you take Ivy Gourd with Saxagliptin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Ivy Gourd and Saxagliptin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Saxagliptin and Ivy Gourd?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.