Drug & supplement interaction

Ivy Gourd + Insulin determir

Insulin determir brand name: Levemir.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Ivy Gourd has a moderate interaction with Insulin determir. Ivy gourd may lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceA
What do Severity, Likelihood & Evidence mean?
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Interaction report

Ivy Gourd and Insulin determir

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Insulin determir

Insulin determir falls under ANTIDIABETES DRUGS — the group Ivy Gourd interacts with.

Ivy gourd may lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
Severity Moderate Likelihood Probable Evidence A

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: ivy gourd may nudge your blood sugar down on its own, and Levemir (insulin detemir) is already designed to lower it. Stack the two together and those effects can add up, which means your sugar could drop lower than you intend. That raises the chance of hypoglycemia (low blood sugar), with symptoms like shakiness, sweating, a racing heart, dizziness, confusion, or feeling suddenly hungry.

This isn't a reason to panic, and it's not about insulin building up in your body. It's just two blood-sugar-lowering things working in the same direction, and good human studies back this up. If you want to try ivy gourd, check your glucose more often at first and talk with your pharmacist or doctor before changing anything. Please don't adjust your insulin dose on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Khan AK, AKhtar S, Mahtab H. Treatment of diabetes mellitus with Coccinia indica. Br Med J 1980;280:1044. PubMed
  2. Venkateswaran, S. and Pari, L. Effect of Coccinia indica leaf extract on plasma antioxidants in streptozotocin- induced experimental diabetes in rats. Phytother.Res 2003;17(6):605-608.
  3. Kuriyan, R., Rajendran, R., Bantwal, G., and Kurpad, A. V. Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diabetes Care 2008;31(2):216-220.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Ivy Gourd Also Interacts With Other Medications

Ivy Gourd has 85 moderate known drug interactions in our database — the Insulin determir one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Insulin determir)
Taking anything else?

Check Another of Your Medications Against Ivy Gourd

Covers the 2,830 medications we’ve checked against Ivy Gourd. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin determir

This page covers Ivy Gourd only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin determir page lists 242 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Chelation Therapy Products (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 211 moderate · 29 minor.

From our pharmacist’s overview on the Insulin determir page

“Anyone using insulin detemir (Levemir) should treat this list with real caution, because nearly every one of the 242 ingredients on it acts on blood sugar, and most stack extra glucose-lowering on top of the insulin you already inject. Only two carry a major rating, but both deserve understanding first: Siberian cocklebur, which has ca…”

Reviewed by 2 · Jul 18, 2026

Open the Insulin determir interaction page

One more smart check

Taking Ivy Gourd as Part of a Dietary Supplement Product? Check It for Interactions

We hold 13 real supplement products containing Ivy Gourd, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ivy Gourd. Your product may carry other ingredients that interact with Insulin determir too, on top of Ivy Gourd — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ivy Gourd and Insulin determir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ivy Gourd
Top half

#511 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin determir
Steady interest

#2,040 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Ivy Gourd

What is Ivy Gourd?

  • Blood sugar support
  • Digestive complaints
  • Skin conditions
  • General wellness and nutrition

Ivy gourd is a tropical vine widely eaten as a vegetable and used in traditional medicine, most often for blood sugar support. Early human research hints it may modestly lower blood sugar, but the evidence is limited and not strong enough to replace standard diabetes care. If you have diabetes or take medicine, talk to your pharmacist or doctor before using ivy gourd supplements.

Read the full Ivy Gourd monograph & all interactions
Medication

About Insulin Detemir (rDNA Origin) Injection

What Is Insulin Detemir (rDNA Origin) Injection Used For?

Brand name: Levemir

Levemir (insulin detemir) is used to improve blood sugar (glucose) control in adults and children with type 1 diabetes or type 2 diabetes. It is a basal insulin, meaning it works around the clock to keep background blood sugar levels steady.

Levemir is not recommended for treating diabetic ketoacidosis (a dangerous buildup of acids in the blood that requires a different type of insulin).

See full Insulin Detemir (rDNA Origin) Injection drug information
Keep checking

Other Drugs & Ivy Gourd

Browse every other medication we’ve checked against Ivy Gourd — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Ivy Gourd page.

No interaction 2,744 drugs checked — show the list

We also checked Ivy Gourd against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Ivy Gourd list.

See the full Ivy Gourd interactions page
See every supplement checked against Insulin determir, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Ivy Gourd monograph › Uses, safety, and every drug interaction in one place Insulin determir supplement interactions › Every supplement checked against Insulin determir, ranked by severity Insulin Detemir (rDNA Origin) Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Ivy Gourd and Insulin determir Together: Common Questions

Can you take Ivy Gourd with Insulin determir?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Ivy Gourd and Insulin determir interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin determir and Ivy Gourd?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.