Medication interaction hub

What Supplements Interact with Insulin determir?

Insulin determir brand name: Levemir. Every interaction below applies to the brands too.

242 Interactions 2 Major 211 Moderate 29 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Insulin determir? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Insulin determir against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anyone using insulin detemir (Levemir) should treat this list with real caution, because nearly every one of the 242 ingredients on it acts on blood sugar, and most stack extra glucose-lowering on top of the insulin you already inject. Only two carry a major rating, but both deserve understanding first: Siberian cocklebur, which has caused severe low blood sugar in people soon after eating it, and chelation products containing EDTA, which can drop glucose sharply and may also bind the zinc that insulin products rely on.

The 211 moderate entries are mostly herbs and foods with modest glucose-lowering evidence, fenugreek, bitter melon, and ginseng among them, while a smaller group pulls the opposite direction. Niacin and ephedra can raise blood sugar and blunt what your insulin is doing, and fasting regimens raise the odds of a low. Either direction means checking your glucose more often after adding one.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 211 Minor 29 No known interaction 1,210

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Insulin determir: Top Interactions at a Glance

The Insulin determir supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 242 interacting ingredients — plus 1,210 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Insulin determir Combinations Today

The Insulin determir + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Chromium + Insulin determiri

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Apple Cider Vinegar + Insulin determiri

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.

Read the full interaction Minor Likelihood Unlikely Alpha-lipoic Acid + Insulin determiri

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Minor Likelihood Unlikely Kudzu + Insulin determiri

Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Probable Vanadium + Insulin determiri

Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Galbanum + Insulin determiri

Theoretically, taking galbanum with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Insulin determir

All 1,452 ingredients in our database, ranked by severity — 242 with a Insulin determir interaction on file and 1,210 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Insulin determir?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Chromium with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Full Chromium + Insulin determir answer

Can you take Apple Cider Vinegar with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.

Full Apple Cider Vinegar + Insulin determir answer

Can you take Alpha-lipoic Acid with Insulin determir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Full Alpha-lipoic Acid + Insulin determir answer

Can you take Kudzu with Insulin determir?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking kudzu with antidiabetes drugs might increase the risk of hypoglycemia.

Full Kudzu + Insulin determir answer

Can you take Vanadium with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Vanadium + Insulin determir answer

Can you take Sesame with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking sesame oil with antidiabetes drugs might increase the risk of hypoglycemia.

Full Sesame + Insulin determir answer

Can you take Shilajit with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.

Full Shilajit + Insulin determir answer

Can you take Solomon's Seal with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may enhance hypoglycemic drug effects and alter blood glucose control.

Full Solomon's Seal + Insulin determir answer

Can you take Soy with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Soy can lower blood glucose and have additive effects with antidiabetes drugs.

Full Soy + Insulin determir answer

Can you take Spinach with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There are claims that spinach leaves have hypoglycemic effects.

Full Spinach + Insulin determir answer

Can you take Stereospermum with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that stereospermum can have hypoglycemic effects.

Full Stereospermum + Insulin determir answer

Can you take Stinging Nettle with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, stinging nettle might have additive effects with antidiabetes drugs.

Full Stinging Nettle + Insulin determir answer

Can you take Sunflower Oil with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.

Full Sunflower Oil + Insulin determir answer

Can you take Tamarind with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tamarind seed extract might have additive effects when used with antidiabetes drugs.

Full Tamarind + Insulin determir answer

Can you take Terminalia with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and in...

Full Terminalia + Insulin determir answer

Can you take Terminalia Bellirica with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica with antidiabetes drugs could affect blood sugar control and increase the risk of hyp...

Full Terminalia Bellirica + Insulin determir answer

Can you take Terminalia Chebula with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypog...

Full Terminalia Chebula + Insulin determir answer

Can you take Theaflavin with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal diabetic model, giving theaflavin reduced fasting blood glucose, with an effect comparable to metformin.

Full Theaflavin + Insulin determir answer

Can you take Tinospora Cordifolia with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Tinospora Cordifolia + Insulin determir answer

Can you take Tiratricol with Insulin determir?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tiratricol might interfere with blood glucose control.

Full Tiratricol + Insulin determir answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Insulin determir is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Insulin determir, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Insulin determir sits in 2 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Insulin determir through this category.

Insulin 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Insulin determir through this category.

About Insulin determir

Insulin detemir is a long-acting basal insulin used to improve blood sugar control in adults and children with diabetes mellitus.

Generic name: Insulin determir  ·  Brand name: Levemir.

See the full Insulin Detemir (rDNA Origin) Injection drug information

Related: does Insulin determir deplete any nutrients?

Insulin determir has 2 reported nutrient associations in the research literature — see the Insulin determir nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Insulin determir

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Insulin determir.

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Pharmacist Counseling Corner

Insulin determir & Supplements: Common Questions

What supplements interact with Insulin determir?
More than you might expect — 242 in total, though they are far from equal: 2 are rated major, 211 moderate, and 29 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Chelation Therapy Products, American Ginseng.
Which Insulin determir supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Chelation Therapy Products — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Insulin determir?
Usually yes — most people on Insulin determir can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Levemir have the same supplement interactions as Insulin determir?
Yes — Levemir all contain Insulin determir, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Insulin determir deplete any vitamins or nutrients?
It might — Insulin determir has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Insulin determir nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Insulin determir and my other medications?
This page covers Insulin determir against supplements and herbal ingredients. Checking Insulin determir against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Insulin Detemir (rDNA Origin) Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.