Medication interaction hub

What Supplements Interact with Insulin Glargine (rDNA)?

Insulin Glargine (rDNA) brand name: Lantus. Every interaction below applies to the brands too.

242 Interactions 2 Major 211 Moderate 29 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Insulin Glargine (rDNA)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Insulin Glargine (rDNA) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

This page for insulin glargine (Lantus) runs to 242 ingredients, and it earns real care, because nearly everything on it moves blood sugar while your basal insulin dose stays fixed. Most add to the glucose-lowering effect and raise the odds of a low. The two rated major come first: Siberian cocklebur, which has caused severe hypoglycemia in humans, and chelation products with EDTA, which can drop glucose sharply and may also interfere with the insulin itself.

A smaller set pulls the other way. Niacin can raise blood sugar and blunt your insulin, and alcohol can push readings in either direction. The remaining 211 moderate and 29 minor entries are mostly common herbs and extracts that quietly lower glucose. Glargine works as an all-day background dose you cannot adjust meal by meal, so a supplement that shifts your sugar for hours carries more weight than it would with a mealtime insulin.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 211 Minor 29 No known interaction 1,210

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Insulin Glargine (rDNA): Top Interactions at a Glance

The Insulin Glargine (rDNA) supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 242 interacting ingredients — plus 1,210 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Insulin Glargine (rDNA) Combinations Today

The Insulin Glargine (rDNA) + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Apple Cider Vinegar + Insulin Glargine (rDNA)i

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.

Read the full interaction Minor Likelihood Unlikely Black Tea + Insulin Glargine (rDNA)i

Theoretically, taking black tea with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Minor Likelihood Unlikely Green Tea + Insulin Glargine (rDNA)i

Theoretically, taking green tea with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Moderate Likelihood Possible Terminalia + Insulin Glargine (rDNA)i

Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of h...

Read the full interaction Minor Likelihood Unlikely Glucosamine + Insulin Glargine (rDNA)i

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.

Read the full interaction Moderate Likelihood Probable Fenugreek + Insulin Glargine (rDNA)i

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Insulin Glargine (rDNA)

All 1,452 ingredients in our database, ranked by severity — 242 with a Insulin Glargine (rDNA) interaction on file and 1,210 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Insulin Glargine (rDNA)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Apple Cider Vinegar with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.

Full Apple Cider Vinegar + Insulin Glargine (rDNA) answer

Can you take Black Tea with Insulin Glargine (rDNA)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking black tea with antidiabetes drugs might interfere with blood glucose control.

Full Black Tea + Insulin Glargine (rDNA) answer

Can you take Green Tea with Insulin Glargine (rDNA)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking green tea with antidiabetes drugs might interfere with blood glucose control.

Full Green Tea + Insulin Glargine (rDNA) answer

Can you take Terminalia with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and in...

Full Terminalia + Insulin Glargine (rDNA) answer

Can you take Glucosamine with Insulin Glargine (rDNA)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.

Full Glucosamine + Insulin Glargine (rDNA) answer

Can you take Tiratricol with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tiratricol might interfere with blood glucose control.

Full Tiratricol + Insulin Glargine (rDNA) answer

Can you take Tribulus with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Tribulus + Insulin Glargine (rDNA) answer

Can you take Tronadora with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of tronadora and antidiabetes drugs might increase the risk of hypoglycemia.

Full Tronadora + Insulin Glargine (rDNA) answer

Can you take Turkey Tail Mushroom with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turkey tail mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turkey Tail Mushroom + Insulin Glargine (rDNA) answer

Can you take Turmeric with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking turmeric with antidiabetes drugs might increase the risk of hypoglycemia.

Full Turmeric + Insulin Glargine (rDNA) answer

Can you take Weight Watchers Diet with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Following the Weight Watchers diet while taking antidiabetes drugs may increase the risk of hypoglycemia.

Full Weight Watchers Diet + Insulin Glargine (rDNA) answer

Can you take Wheatgrass with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking wheatgrass with antidiabetes drugs might lower blood glucose levels and increase the risk of hypoglycemia.

Full Wheatgrass + Insulin Glargine (rDNA) answer

Can you take White Horehound with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that white horehound might lower blood glucose.

Full White Horehound + Insulin Glargine (rDNA) answer

Can you take White Mulberry with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full White Mulberry + Insulin Glargine (rDNA) answer

Can you take White Pepper with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that piperine, a constituent of white pepper, reduces blood glucose levels.

Full White Pepper + Insulin Glargine (rDNA) answer

Can you take Winter Cherry with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal diabetic models, winter cherry extract decreases blood glucose.

Full Winter Cherry + Insulin Glargine (rDNA) answer

Can you take Zeaxanthin with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.

Full Zeaxanthin + Insulin Glargine (rDNA) answer

Can you take Zizyphus with Insulin Glargine (rDNA)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Zizyphus + Insulin Glargine (rDNA) answer

Can you take Anhydrous Crystalline Maltose with Insulin Glargine (rDNA)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Maltose, a disaccharide composed of two glucose molecules, has the potential to affect blood sugar levels similarly to table sugar (sucrose)...

Full Anhydrous Crystalline Maltose + Insulin Glargine (rDNA) answer

Can you take Calea Zacatechichi with Insulin Glargine (rDNA)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking Calea zacatechichi with antidiabetes drugs might increase the risk of hypoglycemia.

Full Calea Zacatechichi + Insulin Glargine (rDNA) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Insulin Glargine (rDNA) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Insulin Glargine (rDNA), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Insulin Glargine (rDNA) sits in 2 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Insulin Glargine (rDNA) through this category.

Insulin 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Insulin Glargine (rDNA) through this category.

About Insulin Glargine (rDNA)

Insulin glargine is a long-acting insulin analog used to improve blood sugar control in adults and children with type 1 diabetes, and in adults with type 2 diabetes.

Generic name: Insulin Glargine (rDNA)  ·  Brand name: Lantus.

See the full Insulin Glargine (rDNA origin) Injection drug information

Related: does Insulin Glargine (rDNA) deplete any nutrients?

Insulin Glargine (rDNA) has 2 reported nutrient associations in the research literature — see the Insulin Glargine (rDNA) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Insulin Glargine (rDNA)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Insulin Glargine (rDNA).

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Pharmacist Counseling Corner

Insulin Glargine (rDNA) & Supplements: Common Questions

What supplements interact with Insulin Glargine (rDNA)?
More than you might expect — 242 in total, though they are far from equal: 2 are rated major, 211 moderate, and 29 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Chelation Therapy Products, American Ginseng.
Which Insulin Glargine (rDNA) supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Chelation Therapy Products. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Insulin Glargine (rDNA)?
Usually yes — most people on Insulin Glargine (rDNA) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Lantus have the same supplement interactions as Insulin Glargine (rDNA)?
Yes — Lantus all contain Insulin Glargine (rDNA), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Insulin Glargine (rDNA) deplete any vitamins or nutrients?
It might — Insulin Glargine (rDNA) has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Insulin Glargine (rDNA) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Insulin Glargine (rDNA) and my other medications?
This page covers Insulin Glargine (rDNA) against supplements and herbal ingredients. Checking Insulin Glargine (rDNA) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Insulin Glargine (rDNA origin) Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.