Medication interaction hub

What Supplements Interact with Insulin Glargine Recombinant?

Insulin Glargine Recombinant brand name: Toujeo Solostar. Every interaction below applies to the brands too.

242 Interactions 2 Major 211 Moderate 29 Minor
Curated & coded by · Clinical Pharmacist · Updated September 30, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Insulin Glargine Recombinant? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Insulin Glargine Recombinant against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you inject insulin glargine (Toujeo Solostar), this list deserves real respect, because all 242 ingredients on it bear on the number you track daily, your blood sugar. Most of the 211 moderate entries add to insulin's glucose-lowering effect and can tip you into hypoglycemia, a dangerous low, while a smaller group pushes sugar upward and blunts your dose. Two rate major, and Siberian cocklebur stands out; its seeds have caused severe low blood sugar in people soon after eating them.

The other major entry is chelation therapy with EDTA, which can drop glucose severely and may also bind the zinc in the insulin itself. Skip both outright. Among the moderates, surprises hide in plain sight: beer counts, since alcohol impairs your liver's release of sugar while its carbohydrates push readings up. Only 29 of the 242 rate minor, which tells you how few of these you can shrug off.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 211 Minor 29 No known interaction 1,210

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Insulin Glargine Recombinant: Top Interactions at a Glance

The most significant Insulin Glargine Recombinant supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 242 interacting ingredients — plus 1,210 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Insulin Glargine Recombinant + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Insulin Glargine Recombinanti

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction Major Likelihood Probable Chelation Therapy Products + Insulin Glargine Recombinanti

Ethylenediamine tetraacetic acid (EDTA) can decrease the activity of insulin and increase the risk for hypoglycemia.

Read the full interaction
The complete list

Every Supplement Checked Against Insulin Glargine Recombinant

All 1,452 ingredients in our database, ranked by severity — 242 with a Insulin Glargine Recombinant interaction on file and 1,210 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Insulin Glargine Recombinant?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Goldenseal with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Goldenseal + Insulin Glargine Recombinant answer

Can you take Guarumo with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some clinical evidence suggests that drinking tea prepared with guarumo leaf might lower blood glucose levels in people with type 2 diabetes...

Full Guarumo + Insulin Glargine Recombinant answer

Can you take Guava with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antidiabetes drugs might have additive effects and increase the risk of hypoglycemia.

Full Guava + Insulin Glargine Recombinant answer

Can you take Hibiscus Sabdariffa with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Hibiscus sabdariffa with antidiabetes drugs might increase the risk of hypoglycemia.

Full Hibiscus Sabdariffa + Insulin Glargine Recombinant answer

Can you take Hollyhock with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal and in vitro research shows that hollyhock flower extracts might lower blood glucose levels.

Full Hollyhock + Insulin Glargine Recombinant answer

Can you take Holy Basil with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Holy Basil + Insulin Glargine Recombinant answer

Can you take Hoodia with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119...

Full Hoodia + Insulin Glargine Recombinant answer

Can you take Horsetail with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.

Full Horsetail + Insulin Glargine Recombinant answer

Can you take Hydrazine Sulfate with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking hydrazine sulfate concomitantly with antidiabetes drugs could increase the risk for hypoglycemia.

Full Hydrazine Sulfate + Insulin Glargine Recombinant answer

Can you take Indian Cassia with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian cassia might have additive effects with antidiabetes drugs.

Full Indian Cassia + Insulin Glargine Recombinant answer

Can you take Indian Gooseberry with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.

Full Indian Gooseberry + Insulin Glargine Recombinant answer

Can you take Indian Long Pepper with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Indian Long Pepper + Insulin Glargine Recombinant answer

Can you take Indian Snakeroot with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Indian snakeroot with antidiabetes drugs might increase the risk of hypoglycemia.

Full Indian Snakeroot + Insulin Glargine Recombinant answer

Can you take Indigo Pulchra with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, indigo pulchra might lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Full Indigo Pulchra + Insulin Glargine Recombinant answer

Can you take Inositol with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking inositol with antidiabetes drugs might increase the risk of hypoglycemia.

Full Inositol + Insulin Glargine Recombinant answer

Can you take Irvingia Gabonensis with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.

Full Irvingia Gabonensis + Insulin Glargine Recombinant answer

Can you take Jackfruit with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jackfruit might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Jackfruit + Insulin Glargine Recombinant answer

Can you take Jambolan with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that jambolan seed and bark extracts can lower blood glucose levels.

Full Jambolan + Insulin Glargine Recombinant answer

Can you take Japanese Apricot with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Japanese apricot in combination with antidiabetes drugs might lower blood glucose and increase the risk of hypoglycemi...

Full Japanese Apricot + Insulin Glargine Recombinant answer

Can you take Jequirity with Insulin Glargine Recombinant?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that an extract of jequirity can reduce blood glucose levels.

Full Jequirity + Insulin Glargine Recombinant answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Insulin Glargine Recombinant is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Insulin Glargine Recombinant, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Insulin Glargine Recombinant sits in 2 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Insulin Glargine Recombinant through this category.

Insulin 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Insulin Glargine Recombinant through this category.

Related: does Insulin Glargine Recombinant deplete any nutrients?

Insulin Glargine Recombinant has 2 reported nutrient associations in the research literature — see the Insulin Glargine Recombinant nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Insulin Glargine Recombinant

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Insulin Glargine Recombinant.

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Pharmacist Counseling Corner

Insulin Glargine Recombinant & Supplements: Common Questions

What supplements interact with Insulin Glargine Recombinant?
More than you might expect — 242 in total, though they are far from equal: 2 are rated major, 211 moderate, and 29 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Chelation Therapy Products, American Ginseng.
Which Insulin Glargine Recombinant supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Chelation Therapy Products — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Insulin Glargine Recombinant?
Usually yes — most people on Insulin Glargine Recombinant can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Toujeo Solostar have the same supplement interactions as Insulin Glargine Recombinant?
Yes — Toujeo Solostar all contain Insulin Glargine Recombinant, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Insulin Glargine Recombinant deplete any vitamins or nutrients?
It might — Insulin Glargine Recombinant has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Insulin Glargine Recombinant nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Insulin Glargine Recombinant and my other medications?
This page covers Insulin Glargine Recombinant against supplements and herbal ingredients. Checking Insulin Glargine Recombinant against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 30, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.