Saffron - Toujeo Solostar (Insulin Glargine Recombinant) Interaction
Herbal: Saffron
Also Known As: Crocus sativus, Autumn Crocus, Azafrán, Azafron, Croci Stigma, Crocin, Crocus Cultivé, Indian Saffron, Kashmira, Kesar, Kumkuma, Saffron Crocus, Safran, Safran Espagnol, Safran des Indes, Safran Véritable, Spanish Saffron, True Saffron, Zafran
Drug: Insulin Glargine Recombinant
Brand names:
Toujeo Solostar
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Insulin Glargine Recombinant is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Azimi P, Ghiasvand R Feizi A, Hariri M, Abbasi B. Effects of cinnamon, cardamom, saffron, and ginger consumption on markers of glycemic control, lipid profile, oxidative stress, and inflammation in type 2 diabetes. Rev Diabet Stud. 2014 Fall-Winter;11(3-4
- Moravej Aleali A, Amani R, Shahbazian H, Namjooyan F, Latifi SM, Cheraghian B. The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabet
Saffron Overview
Saffron is a spice derived from the dried stigmas of the crocus plant (Crocus sativus). It is native to Southwest Asia and is known for its distinctive golden-yellow color and unique, slightly bitter taste. Saffron is one of the most expensive spices in the world due to the labor-intensive process of harvesting and processing.
Saffron has been used traditionally in cooking and herbal medicine for centuries. It is purported to have a number of potential health benefits, including reducing inflammation, improving mood, improving memory, and reducing the risk of certain types of cancer, but more studies are needed to determine its effects.
Saffron - More Interactions
Saffron interacts with 515 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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