Drug & supplement interaction

Chirata + Insulin Glargine Recombinant

Insulin Glargine Recombinant brand name: Toujeo Solostar.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Chirata has a moderate interaction with Insulin Glargine Recombinant. Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Chirata and Insulin Glargine Recombinant

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Insulin Glargine Recombinant

Insulin Glargine Recombinant falls under ANTIDIABETES DRUGS — the group Chirata interacts with.

Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.
In non-fasted animals pretreated with the hypoglycemic drug tolbutamide, taking chirata 250 mg/kg decreased blood glucose levels. Monitor blood glucose levels closely.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Toujeo (insulin glargine) is a long-acting insulin that steadily lowers your blood sugar throughout the day. Chirata, a bitter Ayurvedic herb, may have its own mild blood-sugar-lowering effect. So the worry here is simple: stacking the two could push your glucose down too far, raising your risk of hypoglycemia. That can show up as shakiness, sweating, a racing heart, confusion, or feeling faint.

I want to keep this in perspective. The evidence is theoretical and comes from an animal study, not from people, so we don't know how strong this is in real life. Still, with insulin even small extra dips matter. If you'd like to try chirata, please check with your pharmacist or doctor first, and monitor your blood sugar more closely than usual.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sekar, B. C., Mukherjee, B., Chakravarti, R. B., and Mukherjee, S. K. Effect of different fractions of Swertia chirayita on the blood sugar level of albino rats. J.Ethnopharmacol. 1987;21(2):175-181. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Chirata Also Interacts With Other Medications

Chirata has 85 moderate known drug interactions in our database — the Insulin Glargine Recombinant one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Insulin Glargine Recombinant)
Taking anything else?

Check Another of Your Medications Against Chirata

Covers the 2,830 medications we’ve checked against Chirata. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin Glargine Recombinant

This page covers Chirata only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Glargine Recombinant page lists 242 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Chelation Therapy Products (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 211 moderate · 29 minor.

From our pharmacist’s overview on the Insulin Glargine Recombinant page

“If you inject insulin glargine (Toujeo Solostar), this list deserves real respect, because all 242 ingredients on it bear on the number you track daily, your blood sugar. Most of the 211 moderate entries add to insulin's glucose-lowering effect and can tip you into hypoglycemia, a dangerous low, while a smaller group pushes sugar upwar…”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Glargine Recombinant interaction page

One more smart check

Taking Chirata as Part of a Dietary Supplement Product? Check It for Interactions

We hold 26 real supplement products containing Chirata, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chirata. Your product may carry other ingredients that interact with Insulin Glargine Recombinant too, on top of Chirata — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chirata and Insulin Glargine Recombinant Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chirata
Steady interest

#1,095 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Glargine Recombinant
Steady interest

#2,071 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Chirata

What is Chirata?

  • Digestive upset and loss of appetite
  • Fever
  • Blood sugar support
  • Liver health support
  • Skin conditions
  • General 'blood purifier' or tonic

Chirata is a very bitter herb used in traditional Ayurvedic and South Asian medicine, mainly for digestion, fever, and as a general tonic. Human evidence for its benefits is limited, so it should not replace proven treatments, and you should talk to a pharmacist or doctor before using it.

Read the full Chirata monograph & all interactions
Keep checking

Other Drugs & Chirata

Browse every other medication we’ve checked against Chirata — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Chirata page.

No interaction 2,744 drugs checked — show the list

We also checked Chirata against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Chirata list.

See the full Chirata interactions page
See every supplement checked against Insulin Glargine Recombinant, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Chirata monograph › Uses, safety, and every drug interaction in one place Insulin Glargine Recombinant supplement interactions › Every supplement checked against Insulin Glargine Recombinant, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Chirata and Insulin Glargine Recombinant Together: Common Questions

Can you take Chirata with Insulin Glargine Recombinant?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Chirata and Insulin Glargine Recombinant interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin Glargine Recombinant and Chirata?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.