Drug & supplement interaction

Lacticaseibacillus Casei + Ceftolozane Sulfate, Tazobactam Sodium

Ceftolozane Sulfate, Tazobactam Sodium brand name: Zerbaxa.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Lacticaseibacillus Casei has a moderate interaction with Ceftolozane Sulfate, Tazobactam Sodium. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lacticaseibacillus Casei and Ceftolozane Sulfate, Tazobactam Sodium

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Ceftolozane Sulfate, Tazobactam Sodium

Ceftolozane Sulfate, Tazobactam Sodium falls under ANTIBIOTIC DRUGS — the group Lacticaseibacillus Casei interacts with.

Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L. casei.
L. casei preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. casei preparations by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: Zerbaxa (ceftolozane and tazobactam) is an antibiotic, and its whole job is to kill bacteria. The catch is that your L. casei probiotic is bacteria, just the friendly kind. So if you take them at the same time, the antibiotic may wipe out a good chunk of those live probiotic organisms before they ever get to work. This doesn't make your Zerbaxa weaker or more dangerous, and it won't cause new side effects. It mainly means you may not get the full benefit you paid for from the probiotic.

Good news is this is theoretical, based on how the two work, not strong studies. If you want to take both, just space them out by at least two hours. Zerbaxa is usually given in the hospital through an IV, so check timing with your pharmacist or nurse.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lacticaseibacillus Casei Also Interacts With Other Medications

Lacticaseibacillus Casei has 181 moderate known drug interactions in our database — the Ceftolozane Sulfate, Tazobactam Sodium one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Ceftolozane Sulfate, Tazobactam Sodium)
Taking anything else?

Check Another of Your Medications Against Lacticaseibacillus Casei

Covers the 2,830 medications we’ve checked against Lacticaseibacillus Casei. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ceftolozane Sulfate, Tazobactam Sodium

This page covers Lacticaseibacillus Casei only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ceftolozane Sulfate, Tazobactam Sodium page lists 27 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Bacillus Coagulans (moderate), Bacillus Subtilis (moderate), Bifidobacterium Animalis Subsp. Lactis (moderate), Bifidobacterium Bifidum (moderate) and Bifidobacterium Breve (moderate).

By severity: 26 moderate · 1 minor.

From our pharmacist’s overview on the Ceftolozane Sulfate, Tazobactam Sodium page

“The supplement interactions on file for Zerbaxa (ceftolozane and tazobactam) all point in one direction, and it is not toward harming you. Every entry is a probiotic or fermented product, things like Lactobacillus acidophilus or fermented milk drinks, and the concern is that this potent antibiotic can kill the live organisms in those p…”

Reviewed by 2 · Jul 18, 2026

Open the Ceftolozane Sulfate, Tazobactam Sodium interaction page

How much people look this up

Where Lacticaseibacillus Casei and Ceftolozane Sulfate, Tazobactam Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lacticaseibacillus Casei
Steady interest

#953 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ceftolozane Sulfate, Tazobactam Sodium
Top 25%

#432 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lacticaseibacillus Casei

What is Lacticaseibacillus Casei?

  • Digestive health
  • Diarrhea (including antibiotic-related)
  • Immune support
  • Constipation
  • Gut microbiome balance

Lacticaseibacillus casei (formerly Lactobacillus casei) is a 'friendly' probiotic bacterium found in fermented foods and many supplements. It is most studied for digestive issues like diarrhea, where some evidence is encouraging, but results vary by strain and condition. It is generally well tolerated in healthy people, but those with weakened immune systems should check with a doctor first.

Read the full Lacticaseibacillus Casei monograph & all interactions
Medication

About Ceftolozane and Tazobactam Injection

What Is Ceftolozane and Tazobactam Injection Used For?

Brand name: Zerbaxa

Zerbaxa (ceftolozane and tazobactam) is used to treat three types of serious bacterial infections in adults and children born at least 32 weeks gestational age. For complicated intra-abdominal infections (serious infections inside the belly), Zerbaxa is always given alongside another antibiotic called metronidazole. It also treats complicated urinary tract infections, including kidney infections (pyelonephritis).

Zerbaxa is also approved to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia — lung infections that develop in the hospital or while a patient is on a breathing machine. It works only against specific bacteria confirmed or strongly suspected to be causing the infection.

See full Ceftolozane and Tazobactam Injection drug information
Keep checking

Other Drugs & Lacticaseibacillus Casei

Browse every other medication we’ve checked against Lacticaseibacillus Casei — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Lacticaseibacillus Casei page.

No interaction 2,648 drugs checked — show the list

We also checked Lacticaseibacillus Casei against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Lacticaseibacillus Casei list.

See the full Lacticaseibacillus Casei interactions page
See every supplement checked against Ceftolozane Sulfate, Tazobactam Sodium, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lacticaseibacillus Casei monograph › Uses, safety, and every drug interaction in one place Ceftolozane Sulfate, Tazobactam Sodium supplement interactions › Every supplement checked against Ceftolozane Sulfate, Tazobactam Sodium, ranked by severity Ceftolozane and Tazobactam Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
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Taking Lacticaseibacillus Casei and Ceftolozane Sulfate, Tazobactam Sodium Together: Common Questions

Can you take Lacticaseibacillus Casei with Ceftolozane Sulfate, Tazobactam Sodium?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lacticaseibacillus Casei and Ceftolozane Sulfate, Tazobactam Sodium interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ceftolozane Sulfate, Tazobactam Sodium and Lacticaseibacillus Casei?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.