Medication interaction hub

What Supplements Interact with Ceftolozane Sulfate, Tazobactam Sodium?

Ceftolozane Sulfate, Tazobactam Sodium brand name: Zerbaxa. Every interaction below applies to the brands too.

27 Interactions 26 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ceftolozane Sulfate, Tazobactam Sodium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ceftolozane Sulfate, Tazobactam Sodium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The supplement interactions on file for Zerbaxa (ceftolozane and tazobactam) all point in one direction, and it is not toward harming you. Every entry is a probiotic or fermented product, things like Lactobacillus acidophilus or fermented milk drinks, and the concern is that this potent antibiotic can kill the live organisms in those products before they do their job. Since Zerbaxa is given for serious infections, usually in a hospital setting, the sensible read is that these combinations are manageable, and what matters is knowing which ones lose their benefit when taken too close together.

Many people reach for a probiotic during antibiotic treatment to steady their gut, and there is no need to abandon that here. Just space it well apart from each Zerbaxa dose. The evidence is largely theoretical but remarkably consistent, and of the 27 ingredients listed, 26 rate moderate, one minor, and none major.

— , Clinical Pharmacist · July 18, 2026

Moderate 26 Minor 1 No known interaction 1,425

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Ceftolozane Sulfate, Tazobactam Sodium: Top Interactions at a Glance

The most significant Ceftolozane Sulfate, Tazobactam Sodium supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 27 interacting ingredients — plus 1,425 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Ceftolozane Sulfate, Tazobactam Sodium + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Probable Bacillus Coagulans + Ceftolozane Sulfate, Tazobactam Sodiumi

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bacillus Subtilis + Ceftolozane Sulfate, Tazobactam Sodiumi

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Animalis Subsp. Lactis + Ceftolozane Sulfate, Tazobactam Sodiumi

Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Bifidum + Ceftolozane Sulfate, Tazobactam Sodiumi

Theoretically, taking Bifidobacterium.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Breve + Ceftolozane Sulfate, Tazobactam Sodiumi

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Longum + Ceftolozane Sulfate, Tazobactam Sodiumi

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction
The complete list

Every Supplement Checked Against Ceftolozane Sulfate, Tazobactam Sodium

All 1,452 ingredients in our database, ranked by severity — 27 with a Ceftolozane Sulfate, Tazobactam Sodium interaction on file and 1,425 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ceftolozane Sulfate, Tazobactam Sodium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Flaxseed with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxse...

Full Flaxseed + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Lactobacillus Jensenii with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Jensenii + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Lactobacillus Johnsonii with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus johnsonii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Johnsonii + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Latilactobacillus Sakei with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L.

Full Latilactobacillus Sakei + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Levilactobacillus Brevis with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Levilactobacillus brevis with antibiotic drugs might decrease the effectiveness of L.

Full Levilactobacillus Brevis + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Ligilactobacillus Salivarius with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Ligilactobacillus salivarius with antibiotic drugs might decrease the effectiveness of L.

Full Ligilactobacillus Salivarius + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Limosilactobacillus Fermentum with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus fermentum with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Fermentum + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Limosilactobacillus Reuteri with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus reuteri with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Reuteri + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Probiotics with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotic drugs with certain probiotics might decrease the effectiveness of probiotics.

Full Probiotics + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Soy with Ceftolozane Sulfate, Tazobactam Sodium?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, antibiotics may decrease the activity of soy isoflavones.

Full Soy + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Bacillus Coagulans with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Bacillus Subtilis with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Full Bacillus Subtilis + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Bifidobacterium Bifidum with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Bifidobacterium Breve with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Bifidobacterium Longum with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Fermented Milk with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Lacticaseibacillus Casei with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Casei + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Lacticaseibacillus Paracasei with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus paracasei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Paracasei + Ceftolozane Sulfate, Tazobactam Sodium answer

Can you take Lacticaseibacillus Rhamnosus with Ceftolozane Sulfate, Tazobactam Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Rhamnosus + Ceftolozane Sulfate, Tazobactam Sodium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ceftolozane Sulfate, Tazobactam Sodium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ceftolozane Sulfate, Tazobactam Sodium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ceftolozane Sulfate, Tazobactam Sodium sits in 1 interaction category. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Ceftolozane Sulfate, Tazobactam Sodium through this category.

About Ceftolozane Sulfate, Tazobactam Sodium

Ceftolozane and tazobactam injection is a combination antibiotic used to treat serious bacterial infections, including complicated abdominal infections, complicated urinary tract infections, and hospital-acquired or ventilator-associated bacterial pneumonia.

Generic name: Ceftolozane Sulfate, Tazobactam Sodium  ·  Brand name: Zerbaxa.

See the full Ceftolozane and Tazobactam Injection drug information

Related: does Ceftolozane Sulfate, Tazobactam Sodium deplete any nutrients?

Ceftolozane Sulfate, Tazobactam Sodium has 7 reported nutrient associations in the research literature — see the Ceftolozane Sulfate, Tazobactam Sodium nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ceftolozane Sulfate, Tazobactam Sodium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ceftolozane Sulfate, Tazobactam Sodium.

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Pharmacist Counseling Corner

Ceftolozane Sulfate, Tazobactam Sodium & Supplements: Common Questions

What supplements interact with Ceftolozane Sulfate, Tazobactam Sodium?
Our database currently documents 27 ingredients with a known Ceftolozane Sulfate, Tazobactam Sodium interaction (0 major, 26 moderate, 1 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 27. The highest-ranked right now: Bacillus Coagulans, Bacillus Subtilis, Bifidobacterium Animalis Subsp. Lactis.
Which Ceftolozane Sulfate, Tazobactam Sodium supplement interactions are the most serious?
None of the Ceftolozane Sulfate, Tazobactam Sodium supplement interactions on file are currently rated major. The most significant are the 26 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Ceftolozane Sulfate, Tazobactam Sodium?
Plenty of supplements coexist fine with Ceftolozane Sulfate, Tazobactam Sodium; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Zerbaxa have the same supplement interactions as Ceftolozane Sulfate, Tazobactam Sodium?
Yes — Zerbaxa all contain Ceftolozane Sulfate, Tazobactam Sodium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ceftolozane Sulfate, Tazobactam Sodium deplete any vitamins or nutrients?
It might — Ceftolozane Sulfate, Tazobactam Sodium has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ceftolozane Sulfate, Tazobactam Sodium nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ceftolozane Sulfate, Tazobactam Sodium and my other medications?
This page covers Ceftolozane Sulfate, Tazobactam Sodium against supplements and herbal ingredients. Checking Ceftolozane Sulfate, Tazobactam Sodium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ceftolozane and Tazobactam Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.