Drug & supplement interaction

Lady Fern + Captopril

Captopril brand names: Capoten, Acepril.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lady Fern and Captopril in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Lady Fern and Captopril

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Captopril and Lady Fern in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lady Fern at all — not against Captopril, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lady Fern safety at a glance

Lady Fern overall Use caution Limited safety data exist; some ferns can be irritating or harmful if eaten raw or in large amounts.
Pregnancy Avoid Not enough safety information; avoid medicinal use during pregnancy.
Breastfeeding Avoid No reliable safety data; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Captopril and Lady Fern? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Captopril’s Own FDA Label Lists

This is not an interaction — none of it involves Lady Fern. These are the most notable effects listed in the ADVERSE REACTIONS section of Captopril’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A stroke or mini-stroke Worth acting on
  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • Low sodium Worth acting on
  • Unsteadiness Worth acting on
  • A heart attack Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on
  • Fainting Worth acting on

Showing the 10 most notable of 55 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Captopril. Read the label on DailyMed › Where a percentage is shown, it is the share of 9,625 voluntary FDA FAERS reports for Captopril that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Lady Fern’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Lady Fern side to compare — that is a limit of the record, not a statement that Lady Fern has no side effects.

From our Q&A

Questions About Lady Fern or Captopril

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lady Fern or Captopril, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Captopril

This page covers Lady Fern only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Captopril page lists 166 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Siberian Cocklebur (major).

By severity: 6 major · 136 moderate · 24 minor.

From our pharmacist’s overview on the Captopril page

“Anyone taking captopril (Capoten), an ACE inhibitor for high blood pressure and heart failure, should treat this list with genuine care rather than a quick skim. Most of the ingredients here act on blood pressure itself, some dropping it lower than intended and others, tyramine among them, pushing it back up and working against the med…”

Reviewed by 2 · Jul 18, 2026

Open the Captopril interaction page

How much people look this up

Where Lady Fern and Captopril Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lady Fern
Steady interest

#1,318 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Captopril
Top half

#975 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Lady Fern is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lady Fern reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lady Fern and Captopril records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lady Fern

What is Lady Fern?

  • Traditional digestive complaints
  • Folk remedy for intestinal worms
  • Topical use for wounds and skin irritation
  • General traditional tonic
  • Eaten as a foraged spring vegetable (fiddleheads)

Lady fern is a woodland fern used in some folk traditions and occasionally foraged for its young fronds (fiddleheads). There is very little scientific evidence to support any medicinal use, and some ferns can be unsafe if raw or improperly prepared, so caution is warranted.

Athyrium filix-femina · Athyriaceae · Rhizome (rootstock) and young fronds (fiddleheads) · Dried rhizome, traditional decoction, occasionally cooked young fronds (fiddleheads) as food

An interaction check asks whether these two react with each other — it does not ask whether Lady Fern is a good idea for someone in your situation. Here is what our Lady Fern record says about it on its own.

Lady Fern: dosing

There is no established or standardized medicinal dose for lady fern. It has not been studied enough to recommend a safe and effective amount for any condition.If you choose to use a product that contains lady fern, follow the directions on the label and do not exceed the suggested amount. For fiddleheads used as food, cook them fully according to trusted preparation guidance.

From our Lady Fern monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lady Fern monograph & all interactions
Medication

About Captopril

What Is Captopril Used For?

Brand names: Capoten, Acepril

Captopril tablets are used to treat high blood pressure (hypertension), heart failure, and left ventricular dysfunction (weakened pumping function of the heart) in stable patients after a heart attack. For the heart attack indication, it helps improve survival and reduces the chance of developing full heart failure.

Captopril tablets are also used to slow the progression of diabetic nephropathy (kidney damage caused by diabetes) in people with type 1 (insulin-dependent) diabetes who have retinopathy and significant protein in their urine. It reduces the risk of the kidneys failing to the point of needing dialysis or a transplant.

Most-Reported Side Effects for Captopril

From FAERS, the FDA’s public side-effect reporting system (9,625 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 615 reports
Hypertension 536 reports
Nausea 508 reports
Diarrhea 470 reports
Dizziness 448 reports
See full Captopril drug information
Keep checking

Other Drugs & Lady Fern

Browse every other medication we’ve checked against Lady Fern — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Lady Fern against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lady Fern list.

See the full Lady Fern interactions page
See every supplement checked against Captopril, ranked by severity
Evidence & sources

Lady Fern References

The 2 sources that drive our Lady Fern monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Lady Fern is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health (NCCIH) Source
  2. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lady Fern and Captopril Together: Common Questions

Is it safe to take Lady Fern with Captopril?
We do not list a known interaction between Lady Fern and Captopril. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Captopril interact with any supplements?
Yes. Captopril has documented interactions with 166 supplements in our database — Lady Fern is not one of them. The Captopril interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lady Fern monograph Uses, safety profile, and every drug interaction in one place Captopril drug information The full plain-English guide to this medication Captopril supplement interactions Every supplement checked against Captopril, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Captopril and Lady Fern?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.