Limosilactobacillus Reuteri + Mesalamine
Mesalamine brand names: Pentasa, Asacol, Canasa, Rowasa, Lialda, and others.
We found no known interaction between Limosilactobacillus Reuteri and Mesalamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mesalamine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Limosilactobacillus Reuteri and Mesalamine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Mesalamine and Limosilactobacillus Reuteri in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Limosilactobacillus Reuteri safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Mesalamine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Mesalamine is filed under a single classification — oral drugs. Limosilactobacillus Reuteri has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Mesalamine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Limosilactobacillus Reuteri Does Interact With Other Medications
Limosilactobacillus Reuteri has 182 moderate known drug interactions in our database — Mesalamine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Limosilactobacillus Reuteri
We haven’t checked that one against Limosilactobacillus Reuteri yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Limosilactobacillus Reuteri. Pick one to open its full report.
Limosilactobacillus Reuteri in Pregnancy & Breastfeeding
When used orally and appropriately.
When used orally and appropriately. Although clinical research during lactation is lacking, no safety concerns have been shown in clinical research involving infants up to 3 months of age.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Mesalamine Products Have a Food Rule — Limosilactobacillus Reuteri Should Not Break It
At least one FDA label for a product containing Mesalamine says to take it with food. If you take Limosilactobacillus Reuteri on an empty stomach out of habit, keep them separate — and take Mesalamine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mesalamine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2 ) Administer mesalamine delayed-release tablets with food.
From the Dosage and Administration section of the FDA label we read for Mesalamine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Mesalamine Is Prescribed For, and What Limosilactobacillus Reuteri Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Mesalamine is a prescription medicine with approved uses on its FDA label. Limosilactobacillus Reuteri is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Mesalamine is prescribed for: Mesalamine is used to treat mildly to moderately active ulcerative colitis — a condition where the lining of the large intestine becomes inflamed and ulcerated. Depending on the product and formulation, it can be used to bring the disease under control (induction of remission) and/or to keep it from coming back (maintenance of remission). Different products target different parts of the lower digestive tract. Oral forms (tablets and capsules) treat the colon more broadly.
Read the rest of what Mesalamine is prescribed for
Rectal forms — including enemas (ROWASA, sfROWASA, mesalamine rectal suspension) — are used for distal ulcerative colitis, proctosigmoiditis, or proctitis (inflammation limited to the lower end of the colon or rectum). Rectal suppositories (CANASA, mesalamine rectal suppositories) are specifically for ulcerative proctitis (inflammation of the rectum only).
Limosilactobacillus Reuteri has been studied for:
-
Ulcerative colitis studied, not established Limosilactobacillus Reuteri has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Limosilactobacillus Reuteri for ulcerative colitis
It is unclear if giving Limosilactobacillus reuteri by enema is beneficial for ulcerative colitis.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Mesalamine on your own; if you are taking Limosilactobacillus Reuteri for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Limosilactobacillus Reuteri or Mesalamine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Limosilactobacillus Reuteri or Mesalamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Mesalamine
This page covers Limosilactobacillus Reuteri only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mesalamine page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Mesalamine page
“Activated charcoal is the one entry here I would treat as a genuine problem for anyone taking mesalamine (Asacol, Lialda, Pentasa, and others). It is the lone major-rated interaction among the 17 on file, because charcoal soaks up drugs in the gut and can pull mesalamine out of the picture before it does its job.”
Reviewed by 2 · Jul 18, 2026
Where Limosilactobacillus Reuteri and Mesalamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,148 of 1,452 supplements looked up here in the last 7 days
#538 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Limosilactobacillus Reuteri reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Limosilactobacillus Reuteri and Mesalamine records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Limosilactobacillus Reuteri
What is Limosilactobacillus Reuteri?
- Infant colic
- Diarrhea (including antibiotic-associated)
- Digestive health
- Oral and gum health
- Constipation
- Immune support
Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a probiotic bacterium found in the human gut and certain fermented foods. It has the most supportive evidence for reducing crying in breastfed infants with colic and for some types of diarrhea, while many other uses remain unproven. It is generally well tolerated in healthy people, but people who are very ill or immunocompromised should talk to a doctor first.
Limosilactobacillus reuteri · Lactobacillaceae · Live bacterial cells (probiotic strains) · Chewable tablets, drops/oils, capsules, powders, fortified foods and yogurt
An interaction check asks whether these two react with each other — it does not ask whether Limosilactobacillus Reuteri is a good idea for someone in your situation. Here is what our Limosilactobacillus Reuteri record says about it on its own.
Limosilactobacillus Reuteri: dosing
There is no single official dose for L. reuteri. Do not assume a higher dose is better.
From our Limosilactobacillus Reuteri monograph — the full record covers uses, side effects and every documented interaction.
About Mesalamine
What Is Mesalamine Used For?
Brand names: Pentasa, Asacol, Canasa, Rowasa, Lialda, Delzicol
Mesalamine is used to treat mildly to moderately active ulcerative colitis — a condition where the lining of the large intestine becomes inflamed and ulcerated. Depending on the product and formulation, it can be used to bring the disease under control (induction of remission) and/or to keep it from coming back (maintenance of remission).
Different products target different parts of the lower digestive tract. Oral forms (tablets and capsules) treat the colon more broadly. Rectal forms — including enemas (ROWASA, sfROWASA, mesalamine rectal suspension) — are used for distal ulcerative colitis, proctosigmoiditis, or proctitis (inflammation limited to the lower end of the colon or rectum). Rectal suppositories (CANASA, mesalamine rectal suppositories) are specifically for ulcerative proctitis (inflammation of the rectum only).
Other Drugs & Limosilactobacillus Reuteri
Browse every other medication we’ve checked against Limosilactobacillus Reuteri — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
182 interactions
- Metronidazole ›
- Doxycycline ›
- Erythromycin ›
- Minocycline ›
- Tetracycline ›
- Amoxicillin ›
- Ciprofloxacin ›
- Penicillin V Potassium ›
- Ampicillin ›
- Ceftazidime ›
- Clindamycin ›
- Penicillin G Potassium ›
- Cephalexin ›
- Dicloxacillin Sodium ›
- Nitrofurantoin ›
- Ofloxacin ›
- Rifampin ›
- Tobramycin ›
- Azithromycin ›
- Bacitracin ›
- Cefadroxil ›
- Cefuroxime ›
- Chloramphenicol ›
- Cloxacillin Sodium ›
- Dapsone ›
- Doxycycline Hyclate ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Levofloxacin ›
- Neomycin ›
- Amikacin ›
- Cefaclor ›
- Cephradine ›
- Clarithromycin ›
- Cyclacillin ›
- Daptomycin ›
- Gatifloxacin ›
- Lincomycin Hcl ›
- Linezolid ›
- Methenamine Hippurate ›
- Methenamine Mandelate ›
- Minocycline Hydrochloride ›
- Norfloxacin ›
- Oritavancin Diphosphate ›
- Oxacillin ›
- Penicillin G Benzathine ›
- Retapamulin ›
- Trimethoprim ›
- Trovafloxacin ›
- Vancomycin ›
- Amoxicillin Veterinary ›
- Aztreonam ›
- Bacampicillin ›
- Benznidazole ›
- Capreomycin ›
- Carbenicillin Indanyl Sodium ›
- Cefamandole ›
- Cefazolin ›
- Cefdinir ›
- Cefditoren Pivoxil ›
Showing 60 of 182 moderate interactions — see all 182 on the Limosilactobacillus Reuteri page.
No interaction 2,647 drugs checked — show the list
We also checked Limosilactobacillus Reuteri against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Abemaciclib ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Tirzepatide ›
- Semaglutide ›
- Warfarin Sodium ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Bendamustine ›
- Acyclovir ›
- Methotrexate ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Diazepam ›
Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Limosilactobacillus Reuteri list.
Limosilactobacillus Reuteri References
The 14 references that drive our Limosilactobacillus Reuteri monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Savino F, Cordisco L, Tarasco V, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics 2010;126:e526-33.
- Savino F, Pelle E, Palumeri E, et al. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics 2007;119:e124-30.
- Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, de Reijke TM,Prins JM, Koeijers J, Verbon A, Stobberingh E, Geerlings SE. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in p DOI
- Chau K, Lau E, Greenberg S, Jacobson S, Yazdani-Brojeni P, Verma N, Koren G.Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr 2015;166(1):74-8. PubMed
- Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, Corvaglia L, Ballardini E, Bisceglia M, Cinquetti M, Brazzoduro E, Del Vecchio A, Tafuri S, Francavilla R. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional const
- Oncel MY, Sari FN, Arayici S, Guzoglu N, Erdeve O, Uras N, Oguz SS, Dilmen U. Lactobacillus Reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2014;99(2
- Sung V, Hiscock H, Tang ML, Mensah FK, Nation ML, Satzke C, Heine RG, Stock A,Barr RG, Wake M. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2014 1;348:g2107. PubMed
- Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind,placebo-controlled trial. J Pediatr. 2013;162(2):257-62. PubMed
- Husain S, Allotey J, Drymoussi Z, et al. Effects of oral probiotic supplements on vaginal microbiota during pregnancy: a randomised, double-blind, placebo-controlled trial with microbiome analysis. BJOG. 2020;127(2):275-284. PubMed
- Ojetti V, Gigante G, Gabrielli M, et al. The effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial. Eur Rev Med Pharmacol Sci. 2010;14(3):163-70.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Sheyholislami H, Connor KL. Are probiotics and prebiotics safe for use during pregnancy and lactation? A systematic review and meta-analysis. Nutrients. 2021;13(7):2382. PubMed
- Yefet E, Colodner R, Strauss M, Gam Ze Letova Y, Nachum Z. A randomized controlled open label crossover trial to study vaginal colonization of orally administered Lactobacillus reuteri RC-14 and rhamnosus GR-1 in pregnant women at high risk for preterm la
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Limosilactobacillus Reuteri and Mesalamine Together: Common Questions
Is it safe to take Limosilactobacillus Reuteri with Mesalamine?
Do Limosilactobacillus Reuteri and Mesalamine have any of the same side effects?
Should I take Limosilactobacillus Reuteri and Mesalamine at the same time of day?
Are Limosilactobacillus Reuteri and Mesalamine used for the same thing?
How was the Limosilactobacillus Reuteri and Mesalamine combination checked?
Does Limosilactobacillus Reuteri interact with any other medications?
Does Mesalamine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.