Drug & supplement interaction

Lingonberry + Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate

Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate brand name: Xywav.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Lingonberry and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Lingonberry and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate and Lingonberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lingonberry at all — not against Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lingonberry safety at a glance

Lingonberry overall Use caution The berry is generally safe as food, but concentrated supplements are less studied.
Pregnancy Likely Unsafe When used orally because some constituents have mutagenic effects, potentially harming the developing fetus; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally because some constituents have mutagenic effects, potentially harming the developing fetus; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate and Lingonberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Lingonberry and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting / Nausea Additional detail

    Lingonberry

    “Orally, lingonberry seems to be well tolerated. It may cause nausea and vomiting in some patients due to its high tannin content (18).”

    Lingonberry · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, lingonberry may cause nausea and vomiting in some patients due to its high tannin content (18).”

    Lingonberry · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate

    Listed in the ADVERSE REACTIONS section of the FDA label for Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate. Read the label on DailyMed ›

Effects for Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate come from the ADVERSE REACTIONS section of its FDA label; effects for Lingonberry come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Lingonberry in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally because some constituents have mutagenic effects, potentially harming the developing fetus; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Products Have a Food Rule — Lingonberry Should Not Break It

At least one FDA label for a product containing Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate says to take it with food. If you take Lingonberry on an empty stomach out of habit, keep them separate — and take Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Important Administration Information • Administer XYWAV at least 2 hours after eating ( 2.4 ).

From the Dosage and Administration section of the FDA label we read for Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate

This page covers Lingonberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).

By severity: 1 major · 13 moderate · 9 minor.

From our pharmacist’s overview on the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate page

“Xywav combines calcium, magnesium, potassium, and sodium oxybates to treat cataplexy and daytime sleepiness in narcolepsy, and because each nightly dose is measured and timed with real precision, this list deserves genuine attention rather than a quick skim. The one major entry, activated charcoal, can bind the drug in the gut and shar…”

Reviewed by 2 · Jul 18, 2026

Open the Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate interaction page

One more smart check

Taking Lingonberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 67 real supplement products containing Lingonberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lingonberry. Even though Lingonberry itself has no known interaction with Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lingonberry and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lingonberry
Steady interest

#1,109 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate
Top 5%

#67 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lingonberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Lingonberry and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lingonberry

What is Lingonberry?

  • Urinary tract health
  • Antioxidant support
  • Heart and metabolic health
  • Inflammation

Lingonberry is a tart red berry rich in antioxidants such as anthocyanins and the compound arbutin, and it is popular as a food and folk remedy for urinary tract and general wellness. Human evidence for specific health benefits is still limited, so it is best enjoyed as part of a healthy diet rather than relied on to treat any condition. Talk to your pharmacist or doctor before using concentrated extracts, especially if you are pregnant, breastfeeding, or have a medical condition.

Vaccinium vitis-idaea · Ericaceae · Berries and leaves · Juice, dried berries, jam, capsules, extracts, tea (from leaves)

An interaction check asks whether these two react with each other — it does not ask whether Lingonberry is a good idea for someone in your situation. Here is what our Lingonberry record says about it on its own.

Lingonberry: dosing

There is no official or standardized dose for lingonberry supplements. The amount of active compounds can vary widely between products such as juices, dried berries, capsules, and extracts.If you choose to use a lingonberry product, follow the directions on the product label and do not exceed the recommended amount. Eating the berries as food is a simple and generally safe way to enjoy them.

From our Lingonberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lingonberry monograph & all interactions
Medication

About Calcium, Magnesium, Potassium, and Sodium Oxybate

What Is Calcium, Magnesium, Potassium, and Sodium Oxybate Used For?

Brand name: Xywav

Xywav is approved to treat two conditions. First, it treats cataplexy (sudden muscle weakness triggered by emotion) and excessive daytime sleepiness (EDS) in patients aged 7 and older who have narcolepsy. Second, it treats idiopathic hypersomnia (IH) — a condition causing severe, persistent sleepiness with no identifiable cause — in adults.

Both uses are specific to Xywav as an oral solution. The active ingredient, oxybate (also known as GHB), works during sleep to help regulate wakefulness and muscle control.

See full Calcium, Magnesium, Potassium, and Sodium Oxybate drug information
Keep checking

Other Drugs & Lingonberry

Browse every other medication we’ve checked against Lingonberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Lingonberry References

The 4 references that drive our Lingonberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Kontiokari T, Sundqvist K, Nuutinen M, et al. Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. BMJ 2001;322:1571.
  3. Ferrara, P., Romaniello, L., Vitelli, O., Gatto, A., Serva, M., and Cataldi, L. Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in children. Scand.J Urol.Nephrol. 2009;43(5):369-372. PubMed
  4. Pärnnen P, Nikula-Ijs P, Sorsa T. Antimicrobial and Anti-inflammatory Lingonberry Mouthwash - A Clinical Pilot Study in the Oral Cavity. Microorganisms. 2019;7(9):331. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lingonberry and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate Together: Common Questions

Is it safe to take Lingonberry with Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate?
We do not list a known interaction between Lingonberry and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Lingonberry and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Lingonberry and Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate at the same time of day?
At least one FDA label for a product containing Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate says to take it with food. If you take Lingonberry on an empty stomach out of habit, keep them separate and take Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate interact with any supplements?
Yes. Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate has documented interactions with 23 supplements in our database — Lingonberry is not one of them. The Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate and Lingonberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.