Nutmeg + Atovaquone, Proguanil
Atovaquone, Proguanil brand name: Malarone.
We found no known interaction between Nutmeg and Atovaquone, Proguanil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atovaquone, Proguanil states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Nutmeg and Atovaquone, Proguanil
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Atovaquone, Proguanil and Nutmeg in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Nutmeg safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Atovaquone, Proguanil
Interactions in our licensed database are recorded against drug classes, not just single drug names. Atovaquone, Proguanil is filed under 3 classifications — cytochrome p450 2c19 (cyp2c19) substrates, seizure threshold lowering drugs, oral drugs. Nutmeg has documented interactions with 5 drug classes — the most serious being anticholinergic drugs (moderate), cholinergic drugs (moderate) and cns depressants (moderate) — and none of Atovaquone, Proguanil’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Nutmeg Does Interact With Other Medications
Nutmeg has 528 moderate known drug interactions in our database — Atovaquone, Proguanil isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Nutmeg
We haven’t checked that one against Nutmeg yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Nutmeg. Pick one to open its full report.
Nutmeg in Pregnancy & Breastfeeding
When used orally and appropriately in amounts commonly found in foods.
When used orally in medicinal amounts. Nutmeg might have abortifacient activity, and its safrole content might be mutagenic.
When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of nutmeg when used in larger, medicinal amounts during lactation; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Atovaquone, Proguanil Products Have a Food Rule — Nutmeg Should Not Break It
At least one FDA label for a product containing Atovaquone, Proguanil says to take it with food. If you take Nutmeg on an empty stomach out of habit, keep them separate — and take Atovaquone, Proguanil with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atovaquone, Proguanil products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION The daily dose should be taken at the same time each day with food or a milky drink.
From the Dosage and Administration section of the FDA label we read for Atovaquone, Proguanil — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Atovaquone, Proguanil
This page covers Nutmeg only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atovaquone, Proguanil page lists 54 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), Artichoke (moderate), Bacopa (moderate) and Baikal Skullcap (moderate).
By severity: 1 major · 40 moderate · 13 minor.
From our pharmacist’s overview on the Atovaquone, Proguanil page
“Most people taking atovaquone-proguanil (Malarone) are travelers trying to prevent malaria, so this list of 54 interacting supplements deserves real attention, since anything that weakens the drug can leave you exposed to the disease itself. The single major-rated entry is activated charcoal, a common travel remedy for stomach upset, w…”
Reviewed by 2 · Jul 18, 2026
Taking Nutmeg as Part of a Dietary Supplement Product? Check It for Interactions
We hold 182 real supplement products containing Nutmeg, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Nutmeg. Even though Nutmeg itself has no known interaction with Atovaquone, Proguanil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Nutmeg and Atovaquone, Proguanil Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#466 of 1,452 supplements looked up here in the last 7 days
#1,380 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nutmeg reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Nutmeg and Atovaquone, Proguanil records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Nutmeg
What is Nutmeg?
- Digestive upset
- Diarrhea
- Sleep and relaxation
- Pain and inflammation
- Flavoring spice
Nutmeg is a popular cooking spice that has long been used in traditional medicine for digestion and other complaints, but there is little solid human research to support its medicinal use. In normal cooking amounts it is generally safe, but larger "medicinal" doses can cause serious poisoning, so it should never be taken in high amounts.
Myristica fragrans · Myristicaceae · Seed (nutmeg), seed covering (mace), and essential oil · Whole or ground spice, powder, capsules, essential oil
An interaction check asks whether these two react with each other — it does not ask whether Nutmeg is a good idea for someone in your situation. Here is what our Nutmeg record says about it on its own.
Nutmeg: dosing
There is no well-established medicinal dose for nutmeg, and no standardized supplement dose has been proven safe and effective for any health condition. As a spice, the small amounts used in cooking are considered safe.Because the line between a flavoring amount and a toxic amount is not very wide, you should not take large doses of nutmeg for health purposes.
From our Nutmeg monograph — the full record covers uses, side effects and every documented interaction.
About Atovaquone and Proguanil
What Is Atovaquone and Proguanil Used For?
Brand name: Malarone
Atovaquone and proguanil is used for two purposes: preventing P. falciparum malaria before and during travel to areas where malaria is common, and treating an active, uncomplicated P. falciparum malaria infection. This includes regions where other antimalarials — such as chloroquine, mefloquine, halofantrine, and amodiaquine — may no longer be effective due to drug resistance.
Both the adult-strength and pediatric-strength tablet formulations share these same two approved uses. The brand Malarone is approved for both prevention and treatment of P. falciparum malaria in adults and in pediatric patients, with dosing based on body weight for children.
Other Drugs & Nutmeg
Browse every other medication we’ve checked against Nutmeg — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
528 interactions
- Theophylline ›
- Diphenhydramine ›
- Naproxen ›
- Estradiol ›
- Propranolol ›
- Verapamil ›
- Flurazepam ›
- Glycopyrrolate ›
- Triazolam ›
- Zopiclone ›
- Fentanyl ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Temazepam ›
- Carbamazepine ›
- Ipratropium ›
- Morphine Sulfate ›
- Nitrazepam ›
- Procainamide ›
- Acetaminophen ›
- Buprenorphine ›
- Diazepam ›
- Dimenhydrinate ›
- Lofepramine ›
- Meprobamate ›
- Nortriptyline ›
- Oxymorphone ›
- Pilocarpine ›
- Procyclidine ›
- Propoxyphene ›
- Topiramate ›
- Amantadine ›
- Aripiprazole ›
- Bendamustine ›
- Caffeine (otc Drug) ›
- Cetirizine ›
- Clobazam ›
- Clonazepam ›
- Clorazepate ›
- Cyclobenzaprine ›
- Desipramine ›
- Doxepin ›
- Edrophonium ›
- Fluphenazine ›
- Hydromorphone ›
- Hydroxyzine ›
- Hyoscyamine ›
- Levetiracetam ›
- Meclizine ›
- Metoclopramide ›
- Midazolam ›
- Phenobarbital ›
- Riluzole ›
- Scopolamine ›
- Tramadol ›
- Trihexyphenidyl ›
- Trospium ›
- Valproic Acid ›
- Warfarin Sodium ›
Showing 60 of 528 moderate interactions — see all 528 on the Nutmeg page.
No interaction 2,301 drugs checked — show the list
We also checked Nutmeg against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Dextroamphetamine ›
- Quetiapine ›
- Levothyroxine, Liothyronine ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Dapsone ›
- Cyclopentolate ›
- Atorvastatin Calcium ›
- Cephalexin ›
- Mannitol ›
- Roxithromycin ›
- Ezetimibe ›
- Acetylsalicylic Acid ›
- Spironolactone ›
Showing the 60 most looked-up of 2,301 medications checked with no known interaction — see the full Nutmeg list.
Nutmeg References
The 29 references that drive our Nutmeg monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
- Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. DOI
- Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995;217:966-71. PubMed
- Dinakar HS. Acute psychosis associated with nutmeg toxicity. Med Times 1977;105:63-4.
- McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
- Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
- Demetriades AK, Wallman PD, McGuiness A, Gavalas MC. Low cost, high risk: accidental nutmeg intoxication. Emerg Med J 2005;22:223-5. PubMed
- Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6. PubMed
- Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
- Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed
- Shah AM, Calello DP, Quintero-Solivan J, Osterhoudt KC. The not-so-nice spice: a teenage girl with palpitations and dry mouth. Pediatr Emerg Care 2011;27:1205-7. PubMed
- Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
- Williams EY, West F. The use of nutmeg as a psychotropic drug. Report of two cases. J Natl Med Assoc 1968;60:289-90.
- Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed
- Sell AB, Carlini EA. Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology. 1976;14(4):367-77. PubMed
- Fundarò A, Cassone MC. [Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat]. Boll Soc Ital Biol Sper. 1980;56(22):2375-80.
- Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-80. PubMed
- Sherry CJ, Ray LE, Herron RE. The pharmacological effects of the ligroin extract of nutmeg (Myristica fragrans). J Ethnopharmacol. 1982;6(1):61-6.
- Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res. 2007;21(12):1142-5. PubMed
- Van Gils C, Cox PA. Ethnobotany of nutmeg in the Spice Islands. J Ethnopharmacol. 1994;42(2):117-24. PubMed
- Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9. PubMed
- Futrell JM, Rietschel RL. Spice allergy evaluated by results of patch tests. Cutis. 1993;52(5):288-90.
- van den Akker TW, Roesyanto-Mahadi ID, van Toorenenbergen AW, van Joost T. Contact allergy to spices. Contact Dermatitis. 1990;22(5):267-72. PubMed
- Beattie RT. Nutmeg as a psychoactive agent. Br J Addict Alcohol Other Drugs. 1968;63(1):105-9. PubMed
- Beckerman B, Persaud H. Nutmeg overdose: Spice not so nice. Complement Ther Med. 2019;46:44-46. PubMed
- Reynoard J, Torrents R, Domange B, Glaizal M, de Haro L, Simon N. Nutmeg poisoning: Ten years (2008-2018) of experience from the Marseille Poison Control Center. Presse Med. 2019;48(9):994-996. PubMed
- Atherton RR. The 'Nutmeg Challenge': a dangerous social media trend. Arch Dis Child. 2020:archdischild-2020-319407. PubMed
- Medagoda K. A family with nutmeg poisoning due to a home-made 'Covid treatment syrup'. Natl Med J India 2022;35(3):187. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Nutmeg and Atovaquone, Proguanil Together: Common Questions
Is it safe to take Nutmeg with Atovaquone, Proguanil?
Do Nutmeg and Atovaquone, Proguanil have any of the same side effects?
Should I take Nutmeg and Atovaquone, Proguanil at the same time of day?
How was the Nutmeg and Atovaquone, Proguanil combination checked?
Does Nutmeg interact with any other medications?
Does Atovaquone, Proguanil interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.