Nutmeg + Esomeprazole
Esomeprazole brand name: Nexium.
We found no known interaction between Nutmeg and Esomeprazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Esomeprazole states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Nutmeg and Esomeprazole
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Esomeprazole and Nutmeg in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Nutmeg safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Esomeprazole
Interactions in our licensed database are recorded against drug classes, not just single drug names. Esomeprazole is filed under 6 classifications — including proton pump inhibitors (ppis), cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 1a2 (cyp1a2) inducers. Nutmeg has documented interactions with 5 drug classes — the most serious being anticholinergic drugs (moderate), cholinergic drugs (moderate) and cns depressants (moderate) — and none of Esomeprazole’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Nutmeg Does Interact With Other Medications
Nutmeg has 528 moderate known drug interactions in our database — Esomeprazole isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Nutmeg
We haven’t checked that one against Nutmeg yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Nutmeg. Pick one to open its full report.
Nutmeg in Pregnancy & Breastfeeding
When used orally and appropriately in amounts commonly found in foods.
When used orally in medicinal amounts. Nutmeg might have abortifacient activity, and its safrole content might be mutagenic.
When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of nutmeg when used in larger, medicinal amounts during lactation; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Esomeprazole Products Have a Food Rule — Nutmeg Should Not Break It
At least one FDA label for a product containing Esomeprazole says to take it on an empty stomach. Most supplements — Nutmeg included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Esomeprazole on its own and move Nutmeg to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Esomeprazole products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Table 2: Recommended Dosage of Esomeprazole Magnesium Delayed-Release Capsules in Pediatric Patients by Indication Indication Patient Age Recommended Dosage Duration Healing of EE 12 years to 17 years Esomeprazole magnesium delayed-release capsules: 20 mg or 40 mg once daily 4 to 8 Weeks Treatment of Symptomatic GERD 12 years to 17 years Esomeprazole magnesium delayed-release capsules: 20 mg once
From the Dosage and Administration section of the FDA label we read for Esomeprazole — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Nutmeg or Esomeprazole
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Nutmeg or Esomeprazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can You Take Xarelto And Nexium Together? ›
- Can You Take Zyrtec And Xyzal Together? ›
- Taking Nexium With Ibuprofen ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Esomeprazole
This page covers Nutmeg only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Esomeprazole page lists 154 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 102 moderate · 49 minor.
From our pharmacist’s overview on the Esomeprazole page
“St. John's wort can lower the amount of esomeprazole (Nexium) in your blood by speeding up how the liver clears it, which can leave heartburn or ulcer treatment falling short.”
Reviewed by 2 · Jul 18, 2026
Taking Nutmeg as Part of a Dietary Supplement Product? Check It for Interactions
We hold 182 real supplement products containing Nutmeg, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Nutmeg. Even though Nutmeg itself has no known interaction with Esomeprazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Nutmeg and Esomeprazole Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#660 of 1,452 supplements looked up here in the last 7 days
#628 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Nutmeg reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Nutmeg and Esomeprazole records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Nutmeg
What is Nutmeg?
- Digestive upset
- Diarrhea
- Sleep and relaxation
- Pain and inflammation
- Flavoring spice
Nutmeg is a popular cooking spice that has long been used in traditional medicine for digestion and other complaints, but there is little solid human research to support its medicinal use. In normal cooking amounts it is generally safe, but larger "medicinal" doses can cause serious poisoning, so it should never be taken in high amounts.
Myristica fragrans · Myristicaceae · Seed (nutmeg), seed covering (mace), and essential oil · Whole or ground spice, powder, capsules, essential oil
An interaction check asks whether these two react with each other — it does not ask whether Nutmeg is a good idea for someone in your situation. Here is what our Nutmeg record says about it on its own.
Nutmeg: dosing
There is no well-established medicinal dose for nutmeg, and no standardized supplement dose has been proven safe and effective for any health condition. As a spice, the small amounts used in cooking are considered safe.Because the line between a flavoring amount and a toxic amount is not very wide, you should not take large doses of nutmeg for health purposes.
From our Nutmeg monograph — the full record covers uses, side effects and every documented interaction.
About Esomeprazole
What Is Esomeprazole Used For?
Brand name: Nexium
Esomeprazole treats problems caused by excess stomach acid. It's used to heal erosive esophagitis (damage to the esophagus from acid), control GERD (gastroesophageal reflux disease) symptoms like heartburn, and protect the stomach lining in people at risk for ulcers caused by NSAIDs (anti-inflammatory pain relievers like ibuprofen).
It's also used as part of a three-drug combination to wipe out H. pylori — a stomach bacteria linked to ulcers — and for people with rare conditions that cause the stomach to overproduce acid, such as Zollinger-Ellison syndrome.
Most-Reported Side Effects for Esomeprazole
From FAERS, the FDA’s public side-effect reporting system (235,235 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Nutmeg
Browse every other medication we’ve checked against Nutmeg — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
528 interactions
- Theophylline ›
- Diphenhydramine ›
- Naproxen ›
- Estradiol ›
- Propranolol ›
- Verapamil ›
- Flurazepam ›
- Glycopyrrolate ›
- Triazolam ›
- Zopiclone ›
- Fentanyl ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Temazepam ›
- Carbamazepine ›
- Ipratropium ›
- Morphine Sulfate ›
- Nitrazepam ›
- Procainamide ›
- Acetaminophen ›
- Buprenorphine ›
- Diazepam ›
- Dimenhydrinate ›
- Lofepramine ›
- Meprobamate ›
- Nortriptyline ›
- Oxymorphone ›
- Pilocarpine ›
- Procyclidine ›
- Propoxyphene ›
- Topiramate ›
- Amantadine ›
- Aripiprazole ›
- Bendamustine ›
- Caffeine (otc Drug) ›
- Cetirizine ›
- Clobazam ›
- Clonazepam ›
- Clorazepate ›
- Cyclobenzaprine ›
- Desipramine ›
- Doxepin ›
- Edrophonium ›
- Fluphenazine ›
- Hydromorphone ›
- Hydroxyzine ›
- Hyoscyamine ›
- Levetiracetam ›
- Meclizine ›
- Metoclopramide ›
- Midazolam ›
- Phenobarbital ›
- Riluzole ›
- Scopolamine ›
- Tramadol ›
- Trihexyphenidyl ›
- Trospium ›
- Valproic Acid ›
- Warfarin Sodium ›
Showing 60 of 528 moderate interactions — see all 528 on the Nutmeg page.
No interaction 2,301 drugs checked — show the list
We also checked Nutmeg against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Ibuprofen ›
- Methamphetamine ›
- Semaglutide ›
- Sumatriptan ›
- Tirzepatide ›
- Prednisone ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Acyclovir ›
- Lisinopril ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Amphetamine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Dapsone ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Mannitol ›
- Roxithromycin ›
- Atorvastatin Calcium ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Finasteride ›
- Hexobarbitone ›
Showing the 60 most looked-up of 2,301 medications checked with no known interaction — see the full Nutmeg list.
Nutmeg References
The 29 references that drive our Nutmeg monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
- Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. DOI
- Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995;217:966-71. PubMed
- Dinakar HS. Acute psychosis associated with nutmeg toxicity. Med Times 1977;105:63-4.
- McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
- Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
- Demetriades AK, Wallman PD, McGuiness A, Gavalas MC. Low cost, high risk: accidental nutmeg intoxication. Emerg Med J 2005;22:223-5. PubMed
- Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6. PubMed
- Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
- Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed
- Shah AM, Calello DP, Quintero-Solivan J, Osterhoudt KC. The not-so-nice spice: a teenage girl with palpitations and dry mouth. Pediatr Emerg Care 2011;27:1205-7. PubMed
- Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
- Williams EY, West F. The use of nutmeg as a psychotropic drug. Report of two cases. J Natl Med Assoc 1968;60:289-90.
- Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed
- Sell AB, Carlini EA. Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology. 1976;14(4):367-77. PubMed
- Fundarò A, Cassone MC. [Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat]. Boll Soc Ital Biol Sper. 1980;56(22):2375-80.
- Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-80. PubMed
- Sherry CJ, Ray LE, Herron RE. The pharmacological effects of the ligroin extract of nutmeg (Myristica fragrans). J Ethnopharmacol. 1982;6(1):61-6.
- Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res. 2007;21(12):1142-5. PubMed
- Van Gils C, Cox PA. Ethnobotany of nutmeg in the Spice Islands. J Ethnopharmacol. 1994;42(2):117-24. PubMed
- Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9. PubMed
- Futrell JM, Rietschel RL. Spice allergy evaluated by results of patch tests. Cutis. 1993;52(5):288-90.
- van den Akker TW, Roesyanto-Mahadi ID, van Toorenenbergen AW, van Joost T. Contact allergy to spices. Contact Dermatitis. 1990;22(5):267-72. PubMed
- Beattie RT. Nutmeg as a psychoactive agent. Br J Addict Alcohol Other Drugs. 1968;63(1):105-9. PubMed
- Beckerman B, Persaud H. Nutmeg overdose: Spice not so nice. Complement Ther Med. 2019;46:44-46. PubMed
- Reynoard J, Torrents R, Domange B, Glaizal M, de Haro L, Simon N. Nutmeg poisoning: Ten years (2008-2018) of experience from the Marseille Poison Control Center. Presse Med. 2019;48(9):994-996. PubMed
- Atherton RR. The 'Nutmeg Challenge': a dangerous social media trend. Arch Dis Child. 2020:archdischild-2020-319407. PubMed
- Medagoda K. A family with nutmeg poisoning due to a home-made 'Covid treatment syrup'. Natl Med J India 2022;35(3):187. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Esomeprazole Is Linked to Lower Levels of 9 Nutrients
Natural Medicines records Esomeprazole as a medicine that can lower these. This is not an interaction with Nutmeg — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Esomeprazole nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Nutmeg and Esomeprazole Together: Common Questions
Is it safe to take Nutmeg with Esomeprazole?
Do Nutmeg and Esomeprazole have any of the same side effects?
Should I take Nutmeg and Esomeprazole at the same time of day?
How was the Nutmeg and Esomeprazole combination checked?
Does Nutmeg interact with any other medications?
Does Esomeprazole interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Esomeprazole and Nutmeg?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.