Oregano - Promacta (Eltrombopag) Interaction

Interaction Details

Pharmacist Analysis

Oregano (and oregano oil) supplements are generally considered safe and there is no indication that there is an interaction between the drug highlighted in this interaction monograph and oregano.

However, as with all supplements, it is important to talk to your doctor before starting anything new, so you can be appropriately monitored.

In terms of drug interactions that have been reported with oregano, below are some examples.

Anticoagulant; Antiplatelet Drugs

Anticoagulants and antiplatelet drugs work by slowing down or preventing blood clotting. While they are essential medications for individuals with certain conditions, they come with an increased risk of bleeding.

Some studies have reported that oregano oil may also increase the risk of bleeding, as it contains compounds that have antithrombin activity and can inhibit platelet aggregation.

Therefore, taking oregano oil along with anticoagulants or antiplatelet drugs may increase the risk of bleeding, bruising, and other adverse effects.

Anti-Diabetic Drugs

Several studies suggest that oregano supplements may help lower blood glucose (i.e., sugar) levels. In vitro and animal research has shown that oregano extracts might stimulate glucose uptake and reduce blood glucose levels.

Therefore, based on the available evidence, combining oregano oil with antidiabetic drugs could potentially cause blood sugar levels to drop too low, leading to hypoglycemia.

However, it is important to note that studies reporting that oregano can reduce blood glucose levels have not reported it causing hypoglycemia.

References

• Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. PubMed
• Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. PubMed
• Antithrombin activity of some constituents from Origanum vulgare. PubMed
• Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. PubMed

Eltrombopag Overview

• Eltrombopag is used to increase the number of platelets (cells that help the blood clot) to decrease the risk of bleeding in adults and children 1 year of age and older who have chronic immune thrombocytopenia (ITP; an ongoing condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood) and who have not been helped or cannot be treated with other treatments, including medications or surgery to remove the spleen. Eltrombopag is also used to increase the number of platelets in people who have hepatitis C (a viral infection that may damage the liver) so that they can begin and continue treatment with interferon (Peginterferon, Pegintron, others) and ribavirin (Rebetol). Eltrombopag is also used in combination with other medications to treat aplastic anemia (condition in which the body does not make enough new blood cells) in adults and children 2 years of age and older. It is also used to treat aplastic anemia in adults who have not been helped with other medications. Eltrombopag is used to increase the number of platelets enough to decrease the risk of bleeding in people with ITP or aplastic anemia, or to allow treatment with interferon and ribavirin in people with hepatitis C. However it is not used to increase the number of platelets to a normal level. Eltrombopag should not be used to treat people who have low numbers of platelets due to conditions other than ITP, hepatitis C, or aplastic anemia. Eltrombopag is in a class of medications called thrombopoietin receptor agonists. It works by causing the cells in the bone marrow to produce more platelets.

Oregano - More Interactions

Oregano interacts with 205 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.