Drug & supplement interaction

Phenethylamine (pea) + Exenatide Synthetic

Exenatide Synthetic brand name: Bydureon BCISE.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Phenethylamine (pea) and Exenatide Synthetic in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Phenethylamine (pea) and Exenatide Synthetic

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Exenatide Synthetic and Phenethylamine (pea) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phenethylamine (pea) safety at a glance

Phenethylamine (pe... overall Use caution May affect heart rate and blood pressure, and human safety data for supplements is limited.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Exenatide Synthetic and Phenethylamine (pea)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Exenatide Synthetic

Interactions in our licensed database are recorded against drug classes, not just single drug names. Exenatide Synthetic is filed under a single classification — antidiabetes drugs. Phenethylamine (pea) has documented interactions with 2 drug classes — the most serious being monoamine oxidase inhibitors (maois) (moderate) and serotonergic drugs (moderate) — and none of Exenatide Synthetic’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phenethylamine (pea) Does Interact With Other Medications

Phenethylamine (pea) has 187 moderate known drug interactions in our database — Exenatide Synthetic isn’t one of them. If you take anything else, check it against the full list below.

Moderate 187 No known interaction 2,643 (incl. Exenatide Synthetic)
Taking anything else?

Check Another of Your Medications Against Phenethylamine (pea)

Covers the 2,830 medications we’ve checked against Phenethylamine (pea). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Phenethylamine (pea) and Exenatide Synthetic May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Anxiety or restlessness Additional detail

    Phenethylamine (pea)

    “A case of anxiety and agitation has been reported for an individual who consumed a weight loss product containing phenethylamine 200-300 mg, caffeine 500-750 mg, bitter orange 400-600 mg, willow bark 150-225 mg, cayenne pepper 80-120 mg, 1,3-dimethyloamyloamine 70-105 mg, gooseberry extract 40-60 mg, bergamot orange 40-60 mg, and black pepper 10-15 mg, daily for 2 months.”

    Phenethylamine (pea) · Natural Medicines adverse-effect record, reported in anxiety.

    1 source cited
    1. 24343. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.

    Exenatide Synthetic

    Listed in the ADVERSE REACTIONS section of the FDA label for Exenatide Synthetic. Read the label on DailyMed ›

Reported for Phenethylamine (pea) but not commonly for Exenatide Synthetic: a fast or pounding heartbeat and weight loss.

Effects for Exenatide Synthetic come from the ADVERSE REACTIONS section of its FDA label; effects for Phenethylamine (pea) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Exenatide Synthetic

This page covers Phenethylamine (pea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Exenatide Synthetic page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Exenatide Synthetic page

“Exenatide Synthetic (Bydureon BCISE) is a once-weekly injection for type 2 diabetes, and I treat its supplement list with real respect. All 239 ingredients on file act on blood sugar, and most of the 208 moderate entries are herbs and foods that lower it further, stacking extra low-blood-sugar risk onto a drug already doing that job.”

Reviewed by 2 · Jul 18, 2026

Open the Exenatide Synthetic interaction page

One more smart check

Taking Phenethylamine (pea) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 208 real supplement products containing Phenethylamine (pea), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phenethylamine (pea). Even though Phenethylamine (pea) itself has no known interaction with Exenatide Synthetic, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phenethylamine (pea) and Exenatide Synthetic Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phenethylamine (pea)
Top half

#507 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Exenatide Synthetic
Top half

#821 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenethylamine (pea) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phenethylamine (pea) and Exenatide Synthetic records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phenethylamine (pea)

What is Phenethylamine (pea)?

Phenethylamine (pea)
  • Mood support
  • Focus and concentration
  • Energy and pre-workout boost
  • Feeling of well-being
  • Athletic performance

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement is very limited, and it may raise blood pressure or heart rate, so people with heart or blood pressure problems should be cautious and check with a pharmacist or doctor first.

Not a plant part; a naturally occurring monoamine compound (made in the body and found in some foods) · Capsules, tablets, powders (often combined with other ingredients in pre-workout or 'mood' and 'focus' supplements)

An interaction check asks whether these two react with each other — it does not ask whether Phenethylamine (pea) is a good idea for someone in your situation. Here is what our Phenethylamine (pea) record says about it on its own.

Phenethylamine (pea): dosing

There is no well-established or standardized dose for PEA supplements, and reliable studies on safe and effective amounts are lacking. Products vary widely in how much they contain and what else they are combined with.If you choose to try it, follow the directions on the product label and do not exceed the recommended amount.

From our Phenethylamine (pea) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phenethylamine (pea) monograph & all interactions
Medication

About Exenatide Injection

What Is Exenatide Injection Used For?

Brand name: Bydureon BCISE

Exenatide injection is used as an addition to diet and exercise to improve blood sugar control in adults with type 2 diabetes. It is not a substitute for healthy lifestyle changes — it works best when combined with them.

It should not be used together with other exenatide-containing products. The brands Byetta, Bydureon, and BYDUREON BCise all contain exenatide and should never be combined with each other.

See full Exenatide Injection drug information
Keep checking

Other Drugs & Phenethylamine (pea)

Browse every other medication we’ve checked against Phenethylamine (pea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
187Moderate
0Minor
2,642No known interaction
187 Moderate 2,642 No interaction
Moderate

187 interactions

Showing 60 of 187 moderate interactions — see all 187 on the Phenethylamine (pea) page.

No interaction 2,642 drugs checked — show the list

We also checked Phenethylamine (pea) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,642 medications checked with no known interaction — see the full Phenethylamine (pea) list.

See the full Phenethylamine (pea) interactions page
See every supplement checked against Exenatide Synthetic, ranked by severity
Evidence & sources

Phenethylamine (pea) References

The 9 references that drive our Phenethylamine (pea) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  2. Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8(2):168-71.
  3. Xie Z, Miller G. Beta-phenylehtylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008;325(2):617-28.
  4. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
  5. Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur J Pharmacol. 1998;349(2-3):163-9.
  6. Bailey B, Philips S, Boulton A. In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987;12(2):173-8. PubMed
  7. Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Journal of Pharmacy and Pharmacology. 1963;151(1):472-8.
  8. Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997;17(2):206-10.
  9. Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005;26(5):274-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phenethylamine (pea) and Exenatide Synthetic Together: Common Questions

Is it safe to take Phenethylamine (pea) with Exenatide Synthetic?
We do not list a known interaction between Phenethylamine (pea) and Exenatide Synthetic. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Phenethylamine (pea) and Exenatide Synthetic have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Phenethylamine (pea) and Exenatide Synthetic combination checked?
Interactions in our licensed database are recorded against drug classes. Exenatide Synthetic is filed under 1 classification, and Phenethylamine (pea) has documented interactions with 2 drug classes — none of Exenatide Synthetic's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phenethylamine (pea) interact with any other medications?
Yes. Phenethylamine (pea) has 187 documented drug interactions in our database — Exenatide Synthetic is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Exenatide Synthetic interact with any supplements?
Yes. Exenatide Synthetic has documented interactions with 239 supplements in our database — Phenethylamine (pea) is not one of them. The Exenatide Synthetic interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phenethylamine (pea) monograph Uses, safety profile, and every drug interaction in one place Exenatide Injection drug information The full plain-English guide to this medication Exenatide Synthetic supplement interactions Every supplement checked against Exenatide Synthetic, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Exenatide Synthetic and Phenethylamine (pea)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.