Drug & supplement interaction

Phenethylamine (pea) + Trihexyphenidyl

Trihexyphenidyl brand names: Artane, Trihex, Artane Sequels.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Phenethylamine (pea) and Trihexyphenidyl in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Phenethylamine (pea) and Trihexyphenidyl

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trihexyphenidyl and Phenethylamine (pea) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phenethylamine (pea) safety at a glance

Phenethylamine (pe... overall Use caution May affect heart rate and blood pressure, and human safety data for supplements is limited.
Pregnancy Avoid Not enough safety information; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trihexyphenidyl and Phenethylamine (pea)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Trihexyphenidyl

Interactions in our licensed database are recorded against drug classes, not just single drug names. Trihexyphenidyl is filed under 2 classifications — anticholinergic drugs, oral drugs. Phenethylamine (pea) has documented interactions with 2 drug classes — the most serious being monoamine oxidase inhibitors (maois) (moderate) and serotonergic drugs (moderate) — and none of Trihexyphenidyl’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phenethylamine (pea) Does Interact With Other Medications

Phenethylamine (pea) has 187 moderate known drug interactions in our database — Trihexyphenidyl isn’t one of them. If you take anything else, check it against the full list below.

Moderate 187 No known interaction 2,643 (incl. Trihexyphenidyl)
Taking anything else?

Check Another of Your Medications Against Phenethylamine (pea)

Covers the 2,830 medications we’ve checked against Phenethylamine (pea). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Phenethylamine (pea) and Trihexyphenidyl May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Weight loss Additional detail

    Phenethylamine (pea)

    “A case of anxiety and agitation has been reported for an individual who consumed a weight loss product containing phenethylamine 200-300 mg, caffeine 500-750 mg, bitter orange 400-600 mg, willow bark 150-225 mg, cayenne pepper 80-120 mg, 1,3-dimethyloamyloamine 70-105 mg, gooseberry extract 40-60 mg, bergamot orange 40-60 mg, and black pepper 10-15 mg, daily for 2 months.”

    Phenethylamine (pea) · Natural Medicines adverse-effect record, reported in anxiety.

    1 source cited
    1. 24343. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.

    “A case of tachycardia has been reported for an individual who consumed a weight loss product containing phenethylamine 200-300 mg, as well as caffeine 500-750 mg, bitter orange 400-600 mg, willow bark 150-225 mg, cayenne pepper 80-120 mg, 1,3-dimethyloamyloamine 70-105 mg, gooseberry extract 40-60 mg, bergamot orange 40-60 mg, and black pepper 10-15 mg, daily for 2 months.”

    Phenethylamine (pea) · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 24343. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.

    Trihexyphenidyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Trihexyphenidyl. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Phenethylamine (pea)

    Recorded for Phenethylamine (pea) in the same Natural Medicines adverse-effect record shown under Weight loss above.

    Trihexyphenidyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Trihexyphenidyl. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Phenethylamine (pea)

    Recorded for Phenethylamine (pea) in the same Natural Medicines adverse-effect record shown under Weight loss above.

    Trihexyphenidyl

    Listed in the ADVERSE REACTIONS section of the FDA label for Trihexyphenidyl. Read the label on DailyMed ›

Effects for Trihexyphenidyl come from the ADVERSE REACTIONS section of its FDA label; effects for Phenethylamine (pea) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 941 voluntary FDA FAERS reports for Trihexyphenidyl that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Trihexyphenidyl

This page covers Phenethylamine (pea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trihexyphenidyl page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), Angel's Trumpet (moderate) and Bacopa (moderate).

By severity: 3 major · 32 moderate · 11 minor.

From our pharmacist’s overview on the Trihexyphenidyl page

“Trihexyphenidyl (Artane) calms the tremor of Parkinson's disease and the muscle stiffness some antipsychotic drugs cause, and this is a list worth reading closely, since three of its 46 flagged ingredients carry a major rating. Two of those are herbs with the same atropine-like chemistry as the drug itself, piling on dry mouth, blurred…”

Reviewed by 2 · Jul 18, 2026

Open the Trihexyphenidyl interaction page

One more smart check

Taking Phenethylamine (pea) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 208 real supplement products containing Phenethylamine (pea), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phenethylamine (pea). Even though Phenethylamine (pea) itself has no known interaction with Trihexyphenidyl, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phenethylamine (pea) and Trihexyphenidyl Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phenethylamine (pea)
Top half

#501 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trihexyphenidyl
Steady interest

#1,702 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenethylamine (pea) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phenethylamine (pea) and Trihexyphenidyl records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phenethylamine (pea)

What is Phenethylamine (pea)?

Phenethylamine (pea)
  • Mood support
  • Focus and concentration
  • Energy and pre-workout boost
  • Feeling of well-being
  • Athletic performance

Phenethylamine (PEA) is a natural compound made in the body and found in foods like chocolate; supplements are marketed for mood, focus, and energy. Reliable human research on the supplement is very limited, and it may raise blood pressure or heart rate, so people with heart or blood pressure problems should be cautious and check with a pharmacist or doctor first.

Not a plant part; a naturally occurring monoamine compound (made in the body and found in some foods) · Capsules, tablets, powders (often combined with other ingredients in pre-workout or 'mood' and 'focus' supplements)

An interaction check asks whether these two react with each other — it does not ask whether Phenethylamine (pea) is a good idea for someone in your situation. Here is what our Phenethylamine (pea) record says about it on its own.

Phenethylamine (pea): dosing

There is no well-established or standardized dose for PEA supplements, and reliable studies on safe and effective amounts are lacking. Products vary widely in how much they contain and what else they are combined with.If you choose to try it, follow the directions on the product label and do not exceed the recommended amount.

From our Phenethylamine (pea) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phenethylamine (pea) monograph & all interactions
Medication

About Trihexyphenidyl

What Is Trihexyphenidyl Used For?

Brand names: Artane, Trihex, Artane Sequels

Trihexyphenidyl is used as part of treatment for all forms of parkinsonism — including idiopathic (the most common type), postencephalitic (following a brain infection), and arteriosclerotic parkinsonism. It is often added alongside levodopa when levodopa alone isn't fully controlling symptoms.

It is also used to control extrapyramidal reactions (involuntary movement problems) that can be caused by certain psychiatric drugs, including phenothiazines, thioxanthenes, butyrophenones, and dibenzoxazepines.

See full Trihexyphenidyl drug information
Keep checking

Other Drugs & Phenethylamine (pea)

Browse every other medication we’ve checked against Phenethylamine (pea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
187Moderate
0Minor
2,642No known interaction
187 Moderate 2,642 No interaction
Moderate

187 interactions

Showing 60 of 187 moderate interactions — see all 187 on the Phenethylamine (pea) page.

No interaction 2,642 drugs checked — show the list

We also checked Phenethylamine (pea) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,642 medications checked with no known interaction — see the full Phenethylamine (pea) list.

See the full Phenethylamine (pea) interactions page
See every supplement checked against Trihexyphenidyl, ranked by severity
Evidence & sources

Phenethylamine (pea) References

The 9 references that drive our Phenethylamine (pea) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  2. Sabelli H, Fink P, Fawcett J, et al. Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci. 1996;8(2):168-71.
  3. Xie Z, Miller G. Beta-phenylehtylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther. 2008;325(2):617-28.
  4. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Przegl Lek. 2013;70(10):880-3.
  5. Nakamura M, Ishii A, Nakahara D. Characterization of beta-phenyltheylamine-induced monoamine release in rat nucleus accumbens: a microdialysis study. Eur J Pharmacol. 1998;349(2-3):163-9.
  6. Bailey B, Philips S, Boulton A. In vivo release of endogenous dopamine, 5-hydroxytryptamine and some of their metabolites from rat caudate nucleus by phenylethylamine. Neurochem Res. 1987;12(2):173-8. PubMed
  7. Mantegazza P, Riva M. Amphetamine-like activity of beta-phenethylamine after a monoamine oxidase inhibitor in vivo. Journal of Pharmacy and Pharmacology. 1963;151(1):472-8.
  8. Grimsby J, Toth M, Chen K, et al. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997;17(2):206-10.
  9. Lindemann L, Hoener MC. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci. 2005;26(5):274-81. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phenethylamine (pea) and Trihexyphenidyl Together: Common Questions

Is it safe to take Phenethylamine (pea) with Trihexyphenidyl?
We do not list a known interaction between Phenethylamine (pea) and Trihexyphenidyl. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Phenethylamine (pea) and Trihexyphenidyl have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Phenethylamine (pea) and Trihexyphenidyl combination checked?
Interactions in our licensed database are recorded against drug classes. Trihexyphenidyl is filed under 2 classifications, and Phenethylamine (pea) has documented interactions with 2 drug classes — none of Trihexyphenidyl's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phenethylamine (pea) interact with any other medications?
Yes. Phenethylamine (pea) has 187 documented drug interactions in our database — Trihexyphenidyl is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Trihexyphenidyl interact with any supplements?
Yes. Trihexyphenidyl has documented interactions with 46 supplements in our database — Phenethylamine (pea) is not one of them. The Trihexyphenidyl interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phenethylamine (pea) monograph Uses, safety profile, and every drug interaction in one place Trihexyphenidyl drug information The full plain-English guide to this medication Trihexyphenidyl supplement interactions Every supplement checked against Trihexyphenidyl, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trihexyphenidyl and Phenethylamine (pea)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.