Drug & supplement interaction

Picamilon + Paroxetine

Paroxetine brand names: Paxil CR, Paxil, Brisdelle.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Picamilon and Paroxetine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Picamilon and Paroxetine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Paroxetine and Picamilon in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Picamilon safety at a glance

Picamilon overall Use caution Human safety data are limited and its legal status as a supplement is questionable in some countries.
Pregnancy Avoid No reliable safety data exist, so it should be avoided during pregnancy.
Breastfeeding Avoid No safety information is available, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Paroxetine and Picamilon? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Paroxetine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Paroxetine is filed under 12 classifications — including antidepressant drugs, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. Picamilon has documented interactions with 1 drug class — the most serious being niacin (moderate) — and none of Paroxetine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Picamilon Does Interact With Other Medications

Picamilon has 3 moderate known drug interactions in our database — Paroxetine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 3 No known interaction 2,827 (incl. Paroxetine)
Taking anything else?

Check Another of Your Medications Against Picamilon

Covers the 2,830 medications we’ve checked against Picamilon. Pick one to open its full report.

What to actually watch for

What Paroxetine’s Own FDA Label Lists

This is not an interaction — none of it involves Picamilon. These are the most notable effects listed in the ADVERSE REACTIONS section of Paroxetine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Serotonin syndrome Worth acting on
  • Thoughts of self-harm Worth acting on
  • Bone thinning Worth acting on
  • Muscle weakness Worth acting on
  • Memory problems Worth acting on
  • Low sodium Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Chest pain Worth acting on

Showing the 10 most notable of 42 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Paroxetine. Read the label on DailyMed › Picamilon’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Picamilon side to compare — that is a limit of the record, not a statement that Picamilon has no side effects.

From our Q&A

Questions About Picamilon or Paroxetine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Picamilon or Paroxetine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Paroxetine

This page covers Picamilon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Paroxetine page lists 134 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Iboga (major), Lithium (major), 1,3-dmaa (moderate) and 5-htp (moderate).

By severity: 3 major · 105 moderate · 26 minor.

From our pharmacist’s overview on the Paroxetine page

“I treat paroxetine (Paxil, Paxil CR, Brisdelle) as a medication where supplement choices genuinely matter, not one to wave through. This antidepressant raises serotonin, so about twenty of the ingredients listed here, lithium among them, can push serotonin too high and risk serotonin syndrome, a dangerous reaction.”

Reviewed by 2 · Jul 18, 2026

Open the Paroxetine interaction page

One more smart check

Taking Picamilon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 135 real supplement products containing Picamilon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Picamilon. Even though Picamilon itself has no known interaction with Paroxetine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Picamilon and Paroxetine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Picamilon
Top half

#425 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Paroxetine
Top half

#1,200 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Picamilon reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Picamilon and Paroxetine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Picamilon

What is Picamilon?

  • Anxiety and stress
  • Mental focus and cognition
  • Low mood
  • Migraine or headache
  • Fatigue and energy

Picamilon is a synthetic compound made by joining niacin (vitamin B3) and GABA, originally developed in the former Soviet Union as a prescription drug. It is sold in some countries as a supplement for anxiety, focus, and mood, but high-quality human evidence is very limited, and U.S. regulators have stated it does not qualify as a legal dietary supplement ingredient. Talk to a pharmacist or doctor before using it.

Synthetic compound (not from a plant) · Capsules, tablets, powder

An interaction check asks whether these two react with each other — it does not ask whether Picamilon is a good idea for someone in your situation. Here is what our Picamilon record says about it on its own.

Picamilon: dosing

There is no officially established or standardized dose of picamilon for supplement use, and quality control of products is uncertain.If a product is available to you, follow the directions on the label and do not exceed them.

From our Picamilon monograph — the full record covers uses, side effects and every documented interaction.

Read the full Picamilon monograph & all interactions
Medication

About Paroxetine

What Is Paroxetine Used For?

Brand names: Paxil CR, Paxil, Brisdelle

Paroxetine tablets, film-coated tablets, and oral suspensions are approved in adults for major depressive disorder (MDD), obsessive compulsive disorder (OCD), panic disorder, social anxiety disorder, generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD). The extended-release tablet forms (Paxil CR, paroxetine HCL CR, and paroxetine extended-release tablets) are approved in adults for MDD, panic disorder, social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

Brisdelle (paroxetine 7.5 mg capsule) and generic paroxetine capsules are approved specifically for moderate to severe vasomotor symptoms (hot flashes) associated with menopause — not for any psychiatric condition. Paroxetine tablets are not approved for use in children.

Most-Reported Side Effects for Paroxetine

From FAERS, the FDA’s public side-effect reporting system (91,207 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug withdrawal syndrome 6,210 reports
Nausea 6,139 reports
Dizziness 5,469 reports
Fatigue 5,430 reports
Anxiety 5,396 reports
See full Paroxetine drug information
Keep checking

Other Drugs & Picamilon

Browse every other medication we’ve checked against Picamilon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
3Moderate
0Minor
2,826No known interaction
3 Moderate 2,826 No interaction
Moderate

3 interactions

No interaction 2,826 drugs checked — show the list

We also checked Picamilon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Picamilon list.

See the full Picamilon interactions page
See every supplement checked against Paroxetine, ranked by severity
Evidence & sources

Picamilon References

The 3 references that drive our Picamilon monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Avula B, Chittiboyina AG, Sagi S, et al. Identification and quantification of vinpocetine and picamilon in dietary supplements sold in the United States. Drug Test Anal. 2016;8(3-4):334-43. PubMed
  2. Vishnevskii EL, Guseva NB. Validation of the treatment of the neurogenic bladder in children with myelodysplasia using pikamilon [abstract only]. Urol Nefrol (Mosk) 1998;(2):27-30.
  3. Kolomoitseva EM, Ermakova VN, Abdulkadyrova MZh. Results of pikamilon use in the treatment of patients with open-angle glaucoma [abstract only]. Vestn Oftalmol 1994;110(4):4-7.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Picamilon and Paroxetine Together: Common Questions

Is it safe to take Picamilon with Paroxetine?
We do not list a known interaction between Picamilon and Paroxetine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Picamilon and Paroxetine combination checked?
Interactions in our licensed database are recorded against drug classes. Paroxetine is filed under 12 classifications, and Picamilon has documented interactions with 1 drug class — none of Paroxetine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Picamilon interact with any other medications?
Yes. Picamilon has 3 documented drug interactions in our database — Paroxetine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Paroxetine interact with any supplements?
Yes. Paroxetine has documented interactions with 134 supplements in our database — Picamilon is not one of them. The Paroxetine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Picamilon monograph Uses, safety profile, and every drug interaction in one place Paroxetine drug information The full plain-English guide to this medication Paroxetine supplement interactions Every supplement checked against Paroxetine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Paroxetine and Picamilon?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.